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Trim27 Gene Detail
Summary
  • Symbol
    Trim27
  • Name
    tripartite motif-containing 27
  • Synonyms
    Rfp
  • Feature Type
    protein coding gene
  • IDs
    MGI:97904
    NCBI Gene: 19720
  • Gene Overview
    MyGene.info: TRIM27
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:21179450-21194723 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 7.67 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    76 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97904
protein coding gene Chr13:21179445-21194724 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020269
protein coding gene Chr13:18423508-18438586 (+)
A/J MGP_AJ_G0020225
protein coding gene Chr13:18020479-18035543 (+)
AKR/J MGP_AKRJ_G0020201
protein coding gene Chr13:18322813-18337881 (+)
BALB/cJ MGP_BALBcJ_G0020213
protein coding gene Chr13:18084887-18099951 (+)
C3H/HeJ MGP_C3HHeJ_G0020014
protein coding gene Chr13:18426453-18441505 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020657
protein coding gene Chr13:19076269-19091546 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018264
protein coding gene Chr13:16409991-16425587 (+)
CAST/EiJ MGP_CASTEiJ_G0019549
protein coding gene Chr13:18225157-18246359 (+)
CBA/J MGP_CBAJ_G0019978
protein coding gene Chr13:19742242-19757306 (+)
DBA/2J MGP_DBA2J_G0020099
protein coding gene Chr13:17667001-17682065 (+)
FVB/NJ MGP_FVBNJ_G0020081
protein coding gene Chr13:17330137-17345187 (+)
LP/J MGP_LPJ_G0020170
protein coding gene Chr13:18674898-18689956 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020119
protein coding gene Chr13:20148695-20163757 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020685
protein coding gene Chr13:18154392-18169662 (+)
PWK/PhJ MGP_PWKPhJ_G0019314
protein coding gene Chr13:17711364-17726493 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019120
protein coding gene Chr13:17155774-17169824 (+)
WSB/EiJ MGP_WSBEiJ_G0019608
protein coding gene Chr13:18222432-18238636 (+)



Homology
more
  • Human Ortholog
    TRIM27, tripartite motif containing 27
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TRIM27, tripartite motif containing 27
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RFP, RNF76
  • Links
    NCBI Gene ID: 5987
    neXtProt AC: NX_P14373
    UniProt: P14373

  • Chr Location
    6p22.1; chr6:28903002-28923991 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit exhibit increased potassium/calcium channel activity and TCR-stimulated calcium influx in Th1 and Th2 CD4 T cells. Mice homozygous for another gene trap allele exhibit decreased incidence of chemically-induced tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19720 NCBI Gene Model | MGI Sequence Detail 15274 C57BL/6J ±  kb
    transcript NM_009054 RefSeq | MGI Sequence Detail 4204 C57BL/6  
    polypeptide Q62158 UniProt | EBI | MGI Sequence Detail 513 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 111
      Genomic 1
      cDNA 104
      Primer pair 5
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13851, MGI:2145438
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 23
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:266031 Wang T, et al., Trim27 confers myeloid hematopoiesis competitiveness by up-regulating myeloid master genes. J Leukoc Biol. 2018 Oct;104(4):799-809

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory