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Trim27 Gene Detail
Summary
  • Symbol
    Trim27
  • Name
    tripartite motif-containing 27
  • Synonyms
    Rfp
  • Feature Type
    protein coding gene
  • IDs
    MGI:97904
    NCBI Gene: 19720
  • Gene Overview
    MyGene.info: TRIM27
Location & Maps
more
  • Sequence Map
    Chr13:21179445-21194724 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15280 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 7.67 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    TRIM27, tripartite motif containing 27
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TRIM27, tripartite motif containing 27
    Orthology source: HomoloGene
  • Synonyms
    RFP, RNF76
  • Links
    NCBI Gene ID: 5987
    neXtProt AC: NX_P14373

  • Chr Location
    6p22; chr6:28903002-28923991 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Chemically induced (other)
    1
  • Gene trapped
    11
  • Radiation induced
    1
  • Targeted
    8
  • Genomic Mutations
    2 involving Trim27
  • Incidental Mutations
Mice homozygous for a gene trap allele exhibit exhibit increased potassium/calcium channel activity and TCR-stimulated calcium influx in Th1 and Th2 CD4 T cells. Mice homozygous for another gene trap allele exhibit decreased incidence of chemically-induced tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032925 VEGA Gene Model | MGI Sequence Detail 15280 C57BL/6J ±  kb
transcript OTTMUST00000082067 VEGA | MGI Sequence Detail 3923 Not Applicable  
polypeptide OTTMUSP00000043969 VEGA | MGI Sequence Detail 513 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    76 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 105
    Genomic 1
    cDNA 103
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-13851, MGI:2145438
References
more
  • Summaries
    All 50
    Developmental Gene Expression 4
    Gene Ontology 10
    Phenotypes 23
  • Earliest
    J:23895 Amadou C, et al., Localization of new genes and markers to the distal part of the human major histocompatibility complex (MHC) region and comparison with the mouse: new insights into the evolution of mammalian genomes. Genomics. 1995 Mar 1;26(1):9-20
  • Latest
    J:217899 Liu Y, et al., Deficiency of Trim27 protects dopaminergic neurons from apoptosis in the neurotoxin model of Parkinson's disease. Brain Res. 2014 Nov 7;1588:17-24

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory