Rel
Gene Detail

Symbol Name ID

Rel reticuloendotheliosis oncogene MGI:97897

Synonyms

c-Rel

Feature Type

protein coding gene

Genetic Map

Chromosome 11

14.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)

Sequence Map

Chr11:23741514-23770970 bp, - strand From VEGA annotation of GRCm38   29457 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2182  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: rel-related protein
Gene Tree: Rel

Human homologs

Human Homolog		REL, v-rel avian reticuloendotheliosis viral oncogene homolog
NCBI Gene ID		5966
neXtProt AC		NX_Q04864
Human Synonyms		C-Rel
Human Chr (Location)		2p13-p12; chr2:60881574-60944284 (+)  GRCh38

Alleles and phenotypes

All alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous inactivation of this gene causes defects in lymphocyte proliferation, humoral immunity and cytokine production, and may lead to impaired Th1 responses and resistance to autoimmune disease. Mice lacking only the COOH-terminal region show severe hemopoietic defects and lymphoid hyperplasia.

 

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	cytokine production, I-kappaB kinase/NF-kappaB signaling, ...
Component	cytoplasm, nucleus, ...
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)

Data Summary: Results (250)    Tissues (156)    Images (8)
Theiler Stages: 15, 17, 18, 19, 21, 22, 23, 28

Assay Type	Results
RNA in situ	250

cDNA source data(17)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(25) Genomic(2) cDNA(18) Primer pair(3) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000005282 (Evidence)
Ensembl Gene Model	ENSMUSG00000020275 (Evidence)
Entrez Gene	19696 (Evidence)
UniGene	4869
DFCI	TC1588007
DoTS	DT.101361136, DT.87048539
NIA Mouse Gene Index	U032577
Consensus CDS Project	CCDS24480.1
International Mouse Knockout Project Status	Rel

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005282	VEGA Gene Model | MGI Sequence Detail	29457	C57BL/6J
transcript	OTTMUST00000011787	VEGA | MGI Sequence Detail	2799	Not Applicable
polypeptide	OTTMUSP00000005467	VEGA | MGI Sequence Detail	588	Not Applicable

All sequences(21) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(8) : SNPs within 2kb(61 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR002909	Cell surface receptor IPT/TIG
InterPro	IPR014756	Immunoglobulin E-set
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR000451	NF-kappa-B/Rel/Dorsal
InterPro	IPR008967	p53-like transcription factor, DNA-binding
InterPro	IPR011539	Rel homology domain
Protein Ontology	PR:000013874	proto-oncogene c-Rel

References

(Earliest) J:6954 Chen IS, et al., Structure and expression of c-rel, the cellular homolog to the oncogene of reticuloendotheliosis virus strain T. J Virol. 1983 Jan;45(1):104-13
(Latest) J:205159 Burkitt MD, et al., Signaling mediated by the NF-kappaB sub-units NF-kappaB1, NF-kappaB2 and c-Rel differentially regulate Helicobacter felis-induced gastric carcinogenesis in C57BL/6 mice. Oncogene. 2013 Dec 12;32(50):5563-73
All references(178)

Other accession IDs

MGD-MRK-13832