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Rel Gene Detail
Summary
  • Symbol
    Rel
  • Name
    reticuloendotheliosis oncogene
  • Synonyms
    c-Rel
  • Feature Type
    protein coding gene
  • IDs
    MGI:97897
    NCBI Gene: 19696
  • Gene Overview
    MyGene.info: REL
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:23736847-23770970 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34124 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 14.36 cM
  • Mapping Data
    24 experiments
Homology
more
  • Human Ortholog
    REL, REL proto-oncogene, NF-kB subunit
  • Vertebrate Orthologs
    8
  • Human Ortholog
    REL, REL proto-oncogene, NF-kB subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C-Rel
  • Links
    NCBI Gene ID: 5966
    neXtProt AC: NX_Q04864
    UniProt: Q04864

  • Chr Location
    2p16.1; chr2:60881495-60928171 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    62 phenotypes from 6 alleles in 6 genetic backgrounds
    21 phenotypes from multigenic genotypes
    99 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes defects in lymphocyte proliferation, humoral immunity and cytokine production, and may lead to impaired Th1 responses and resistance to autoimmune disease. Mice lacking only the COOH-terminal region show severehemopoietic defects and lymphoid hyperplasia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005282 VEGA Gene Model | MGI Sequence Detail 34124 C57BL/6J ±  kb
    transcript OTTMUST00000011787 VEGA | MGI Sequence Detail 7466 Not Applicable  
    polypeptide OTTMUSP00000005467 VEGA | MGI Sequence Detail 588 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      72 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 2
      cDNA 18
      Primer pair 3
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13832
    References
    more
    • Summaries
      All 210
      Developmental Gene Expression 12
      Gene Ontology 9
      Phenotypes 99
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:252491 Grinberg-Bleyer Y, et al., NF-kappaB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer. Cell. 2017 Sep 07;170(6):1096-1108.e13

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory