Rel MGI Mouse Gene Detail - MGI:97897 - reticuloendotheliosis oncogene

Rel Gene Detail

Symbol

Rel
Name

reticuloendotheliosis oncogene
Synonyms

c-Rel

Feature Type

protein coding gene
IDs

MGI:97897
NCBI Gene: 19696
Gene Overview

MyGene.info: REL

Sequence Map

Chr11:23736847-23770970 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

34124 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 14.36 cM
Mapping Data

24 experiments

Human Ortholog

REL, REL proto-oncogene, NF-kB subunit

Vertebrate Orthologs

8

Human Ortholog

REL, REL proto-oncogene, NF-kB subunit
Orthology source: HomoloGene, HGNC
Synonyms

C-Rel
Links

HGNC:9954

NCBI Gene ID: 5966

neXtProt AC: NX_Q04864

UniProt: Q04864
Chr Location

2p16.1; chr2:60881495-60928171 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 2182
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 macaque, rhesus
HCOP

human homology predictions: REL
Protein SuperFamily

rel-related protein
Gene Tree

Rel

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Phenotype Summary

62 phenotypes from 6 alleles in 6 genetic backgrounds
21 phenotypes from multigenic genotypes
96 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (ENU)

1
Chemically induced (other)

1
Targeted

6
Genomic Mutations

1 involving Rel
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

24 strains or lines available

Homozygous inactivation of this gene causes defects in lymphocyte proliferation, humoral immunity and cytokine production, and may lead to impaired Th1 responses and resistance to autoimmune disease. Mice lacking only the COOH-terminal region show severehemopoietic defects and lymphoid hyperplasia.

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All GO Annotations

40
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

251
Tissues

157
cDNA Data

17
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

ZFIN rel

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Rel interacts with 129 markers (Mir15a, Mir19a, Mir19b-1, ...) View All

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All Sequences

17
RefSeq

2
UniProt

2
CCDS

CCDS24480.1
UniGene

4869

			Length	Strain/Species	Flank
genomic	OTTMUSG00000005282	VEGA Gene Model \| MGI Sequence Detail	34124	C57BL/6J	± kb
transcript	OTTMUST00000011787	VEGA \| MGI Sequence Detail	7466	Not Applicable
polypeptide	OTTMUSP00000005467	VEGA \| MGI Sequence Detail	588	Not Applicable

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SNPs within 2kb

72 from dbSNP Build 142

RFLP

8

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UniProt

2 Sequences
Protein Ontology

PR:000013874 proto-oncogene c-Rel

(term hierarchy)
InterPro Domains

IPR014756 Immunoglobulin E-set

IPR013783 Immunoglobulin-like fold

IPR002909 IPT domain

IPR000451 NF-kappa-B/Dorsal

IPR033926 NFkappaB IPT domain

IPR008967 p53-like transcription factor, DNA-binding

IPR030505 Proto-oncogene c-Rel

IPR032397 Rel homology dimerisation domain

IPR030492 Rel homology domain, conserved site

IPR011539 Rel homology domain (RHD), DNA-binding domain

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All nucleic 25

Genomic 2

cDNA 18

Primer pair 3

Other 2

Microarray probesets 3

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MGD-MRK-13832

Summaries

All 192

Developmental Gene Expression 12

Gene Ontology 9

Phenotypes 96
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:237930 Si H, et al., TNF-alpha modulates genome-wide redistribution of DeltaNp63alpha/TAp73 and NF-kappaB cREL interactive binding on TP53 and AP-1 motifs to promote an oncogenic gene program in squamous cancer. Oncogene. 2016 Nov 03;35(44):5781-5794

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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