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Rel
Gene Detail
 Symbol
Name
ID
Rel
reticuloendotheliosis oncogene
MGI:97897
Synonyms c-Rel
Feature Type protein coding gene
Genetic Map
Chromosome 11
14.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr11:23741514-23770970 bp, - strand
From VEGA annotation of GRCm38

  29457 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2182  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: rel-related protein
Gene Tree: Rel

Human
homologs
Human Homolog REL, v-rel avian reticuloendotheliosis viral oncogene homolog
NCBI Gene ID 5966
neXtProt AC  NX_Q04864
Human Synonyms  C-Rel
Human Chr (Location)  2p13-p12; chr2:60881574-60944284 (+)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene causes defects in lymphocyte proliferation, humoral immunity and cytokine production, and may lead to impaired Th1 responses and resistance to autoimmune disease. Mice lacking only the COOH-terminal region show severe hemopoietic defects and lymphoid hyperplasia.
 
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cytokine production, I-kappaB kinase/NF-kappaB signaling, ...
Component cytoplasm, nucleus, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (250)    Tissues (156)    Images (8)
Theiler Stages: 15, 17, 18, 19, 21, 22, 23, 28
Assay TypeResults
RNA in situ 250
cDNA source data(17)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(25) Genomic(2) cDNA(18) Primer pair(3) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005282 (Evidence)
Ensembl Gene ModelENSMUSG00000020275 (Evidence)
Entrez Gene19696 (Evidence)
UniGene4869
DFCITC1588007
DoTSDT.101361136, DT.87048539
NIA Mouse Gene IndexU032577
Consensus CDS ProjectCCDS24480.1
International Mouse Knockout Project StatusRel
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005282 VEGA Gene Model | MGI Sequence Detail 29457 C57BL/6J ±  kb
transcript OTTMUST00000011787 VEGA | MGI Sequence Detail 2799 Not Applicable 
polypeptide OTTMUSP00000005467 VEGA | MGI Sequence Detail 588 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(2)
Polymorphisms RFLP(8) : SNPs within 2kb(61 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR000451 NF-kappa-B/Rel/Dorsal
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR011539 Rel homology domain
Protein Ontology PR:000013874 proto-oncogene c-Rel
References (Earliest) J:6954 Chen IS, et al., Structure and expression of c-rel, the cellular homolog to the oncogene of reticuloendotheliosis virus strain T. J Virol. 1983 Jan;45(1):104-13
(Latest) J:205159 Burkitt MD, et al., Signaling mediated by the NF-kappaB sub-units NF-kappaB1, NF-kappaB2 and c-Rel differentially regulate Helicobacter felis-induced gastric carcinogenesis in C57BL/6 mice. Oncogene. 2013 Dec 12;32(50):5563-73
All references(178)
Other
accession IDs
MGD-MRK-13832

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory