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Rel Gene Detail
Summary
  • Symbol
    Rel
  • Name
    reticuloendotheliosis oncogene
  • Synonyms
    c-Rel
  • Feature Type
    protein coding gene
  • IDs
    MGI:97897
    NCBI Gene: 19696
  • Gene Overview
    MyGene.info: REL
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:23736847-23770969 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 14.36 cM
  • Mapping Data
    24 experiments
Strain
Comparison
more
  • SNPs within 2kb
    72 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97897
 protein coding gene Chr11:23736847-23770970 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018092
 protein coding gene Chr11:21512326-21549258 (-)
A/J MGP_AJ_G0018065
 protein coding gene Chr11:20666812-20700891 (-)
AKR/J MGP_AKRJ_G0018029
 protein coding gene Chr11:21403204-21437250 (-)
BALB/cJ MGP_BALBcJ_G0018033
 protein coding gene Chr11:20806817-20846095 (-)
C3H/HeJ MGP_C3HHeJ_G0017847
 protein coding gene Chr11:21287088-21323049 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018485
 protein coding gene Chr11:22367386-22402415 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016143
 protein coding gene Chr11:19565059-19599562 (-)
CAST/EiJ MGP_CASTEiJ_G0017408
 protein coding gene Chr11:21316084-21356319 (-)
CBA/J MGP_CBAJ_G0017821
 protein coding gene Chr11:23363711-23398091 (-)
DBA/2J MGP_DBA2J_G0017931
 protein coding gene Chr11:20590895-20624996 (-)
FVB/NJ MGP_FVBNJ_G0017923
 protein coding gene Chr11:20372232-20409060 (-)
LP/J MGP_LPJ_G0018002
 protein coding gene Chr11:21599069-21632928 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017949
 protein coding gene Chr11:23895015-23931356 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018526
 protein coding gene Chr11:21517670-21551662 (-)
PWK/PhJ MGP_PWKPhJ_G0017189
 protein coding gene Chr11:20641491-20677656 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016986
 protein coding gene Chr11:21258600-21292542 (-)
WSB/EiJ MGP_WSBEiJ_G0017462
 protein coding gene Chr11:21150447-21185257 (-)



Homology
more
  • Human Ortholog
    REL, REL proto-oncogene, NF-kB subunit
  • Vertebrate Orthologs
    8
  • Human Ortholog
    REL, REL proto-oncogene, NF-kB subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C-Rel
  • Links
    NCBI Gene ID: 5966
    neXtProt AC: NX_Q04864
    UniProt: Q04864

  • Chr Location
    2p16.1; chr2:60881495-60928171 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    70 phenotypes from 8 alleles in 8 genetic backgrounds
    22 phenotypes from multigenic genotypes
    113 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes defects in lymphocyte proliferation, humoral immunity and cytokine production, and may lead to impaired Th1 responses and resistance to autoimmune disease. Mice lacking only the COOH-terminal region show severehemopoietic defects and lymphoid hyperplasia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    882
  • Tissues
    157
  • cDNA Data
    18
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19696 NCBI Gene Model | MGI Sequence Detail 34123 C57BL/6J ±  kb
    transcript NM_009044 RefSeq | MGI Sequence Detail 7465 C57BL/6  
    polypeptide P15307 UniProt | EBI | MGI Sequence Detail 587 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 2
      cDNA 19
      Primer pair 3
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13832
    References
    more
    • Summaries
      All 224
      Developmental Gene Expression 13
      Gene Ontology 9
      Phenotypes 113
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:276568 DeLaney AA, et al., Caspase-8 promotes c-Rel-dependent inflammatory cytokine expression and resistance against Toxoplasma gondii. Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11926-11935
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    07/07/2020
    MGI 6.15     		The Jackson Laboratory