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Rel
Gene Detail
Symbol

Name
ID
Rel
reticuloendotheliosis oncogene
MGI:97897
Synonyms
c-Rel
Feature Type
protein coding gene
Genetic Map
Chromosome 11
14.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr11:23741514-23770970 bp, - strand
From VEGA annotation of GRCm38

  29457 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2182  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: REL
Protein SuperFamily: rel-related protein
Gene Tree: Rel

Human
homologs
REL, v-rel avian reticuloendotheliosis viral oncogene homolog
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5966
neXtProt AC: NX_Q04864

Human Synonyms: C-Rel

Human Chr (Location): 2p13-p12; chr2:60881495-60928171 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous inactivation of this gene causes defects in lymphocyte proliferation, humoral immunity and cytokine production, and may lead to impaired Th1 responses and resistance to autoimmune disease. Mice lacking only the COOH-terminal region show severe hemopoietic defects and lymphoid hyperplasia.
 
Interactions
Rel interacts with 129 markers (Mir15a, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process cytokine production, I-kappaB kinase/NF-kappaB signaling, ...
Component cytoplasm, cytosol, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (250)    Tissues (156)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 250
cDNA source data(17)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase rel ; ZFIN rel    NEW 
Molecular
reagents
All nucleic(25) Genomic(2) cDNA(18) Primer pair(3) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005282 (Evidence)
Ensembl Gene Model ENSMUSG00000020275 (Evidence)
Entrez Gene 19696 (Evidence)
UniGene 4869
DFCI TC1588007
DoTS DT.101361136, DT.87048539
NIA Mouse Gene Index U032577
Consensus CDS Project CCDS24480.1
International Mouse Phenotyping Consortium Status Rel
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005282 VEGA Gene Model | MGI Sequence Detail 29457 C57BL/6J ±  kb
transcript OTTMUST00000011787 VEGA | MGI Sequence Detail 2799 Not Applicable 
polypeptide OTTMUSP00000005467 VEGA | MGI Sequence Detail 588 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(8) : SNPs within 2kb(61 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR000451 NF-kappa-B/Rel/Dorsal
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR011539 Rel homology domain
Protein Ontology PR:000013874 proto-oncogene c-Rel
References
(Earliest) J:6954 Chen IS, et al., Structure and expression of c-rel, the cellular homolog to the oncogene of reticuloendotheliosis virus strain T. J Virol. 1983 Jan;45(1):104-13
(Latest) J:222748 Burkitt MD, et al., NF-kappaB1, NF-kappaB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice. J Pathol. 2015 Jul;236(3):326-36
All references(179)
Other
accession IDs
MGD-MRK-13832

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory