About   Help   FAQ
Rel Gene Detail
Summary
  • Symbol
    Rel
  • Name
    reticuloendotheliosis oncogene
  • Synonyms
    c-Rel
  • Feature Type
    protein coding gene
  • IDs
    MGI:97897
    NCBI Gene: 19696
  • Gene Overview
    MyGene.info: REL
Location & Maps
more
  • Sequence Map
    Chr11:23736847-23770970 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34124 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 14.36 cM
  • Mapping Data
    24 experiments
Homology
more
  • Human Ortholog
    REL, REL proto-oncogene, NF-kB subunit
  • Vertebrate Orthologs
    8
  • Human Ortholog
    REL, REL proto-oncogene, NF-kB subunit
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C-Rel
  • Links
    NCBI Gene ID: 5966
    neXtProt AC: NX_Q04864

  • Chr Location
    2p13-p12; chr2:60881495-60928171 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    53 phenotypes from 5 alleles in 5 genetic backgrounds
    21 phenotypes from multigenic genotypes
    94 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving Rel
  • Incidental Mutations
Homozygous inactivation of this gene causes defects in lymphocyte proliferation, humoral immunity and cytokine production, and may lead to impaired Th1 responses and resistance to autoimmune disease. Mice lacking only the COOH-terminal region show severehemopoietic defects and lymphoid hyperplasia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005282 VEGA Gene Model | MGI Sequence Detail 34124 C57BL/6J ±  kb
transcript OTTMUST00000011787 VEGA | MGI Sequence Detail 7466 Not Applicable  
polypeptide OTTMUSP00000005467 VEGA | MGI Sequence Detail 588 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    72 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    Genomic 2
    cDNA 18
    Primer pair 3
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13832
References
more
  • Summaries
    All 183
    Developmental Gene Expression 11
    Gene Ontology 8
    Phenotypes 94
  • Earliest
    J:6954 Chen IS, et al., Structure and expression of c-rel, the cellular homolog to the oncogene of reticuloendotheliosis virus strain T. J Virol. 1983 Jan;45(1):104-13
  • Latest
    J:232643 Almaden JV, et al., B-cell survival and development controlled by the coordination of NF-kappaB family members RelB and cRel. Blood. 2016 Mar 10;127(10):1276-86

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory