About   Help   FAQ
Reg2
Gene Detail
Symbol

Name
ID
Reg2
regenerating islet-derived 2
MGI:97896
Synonyms
pancreatic thread protein
Feature Type
protein coding gene
Genetic Map
Chromosome 6
34.77 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:78405155-78408097 bp, + strand
From NCBI annotation of GRCm38

  2943 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68517  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque

HCOP human homology predictions: REG1B
Gene Tree: Reg2

Human
homologs
REG1B, regenerating islet-derived 1 beta
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5968
neXtProt AC: NX_P48304

Human Synonyms: PSPS2, REGH, REGI-BETA, REGL

Human Chr (Location): 2p12; chr2:79085023-79088024 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Spontaneous(1) Targeted(3)
Genomic Mutations involving Reg2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit impaired suckling, delayed hypoglossal myelination and reduced liver regeneration following partial hepatectomy.
 
Interactions
Reg2 interacts with 14 markers (Mir132, Mir194-1, Mir194-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process myelination, suckling behavior
Component extracellular exosome, extracellular region
Function carbohydrate binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (6)    Tissues (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 6
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) Genomic(1) cDNA(30) Primer pair(1) Other(2)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000023140 (Evidence)
Entrez Gene 19693 (Evidence)
UniGene 46360
DFCI TC1580045, TC1715530
DoTS DT.55107538
NIA Mouse Gene Index U007055
Consensus CDS Project CCDS20256.1
International Mouse Phenotyping Consortium Status Reg2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19693 NCBI Gene Model | MGI Sequence Detail 2943 C57BL/6J ±  kb
transcript NM_009043 RefSeq | MGI Sequence Detail 692 C57BL/6 
polypeptide Q08731 UniProt | EBI | MGI Sequence Detail 173 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(63 from dbSNP Build 137)    SNPs within 2kb including multiple locations(73)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR018378 C-type lectin, conserved site
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
Protein Ontology PR:000014392 lithostathine-2
Graphical View of Protein Domain Structure
References
(Earliest) J:13303 Unno M, et al., Structure, chromosomal localization, and expression of mouse reg genes, reg I and reg II. A novel type of reg gene, reg II, exists in the mouse genome. J Biol Chem. 1993 Jul 25;268(21):15974-82
(Latest) J:211052 Liu L, et al., Attenuation of unfolded protein response and apoptosis by mReg2 induced GRP78 in mouse insulinoma cells. FEBS Lett. 2014 May 29;588(11):2016-24
All references(36)
Other
accession IDs
MGD-MRK-13831

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory