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Reg1 Gene Detail
Summary
  • Symbol
    Reg1
  • Name
    regenerating islet-derived 1
  • Synonyms
    pancreatic stone protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:97895
    NCBI Gene: 19692
Location & Maps
more
  • Sequence Map
    Chr6:78422711-78428667 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5957 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 34.77 cM, cytoband C-D
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    REG1A, regenerating family member 1 alpha
  • Vertebrate Orthologs
    5
  • Human Ortholog
    REG1A, regenerating family member 1 alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ICRF, P19, PSP, PSPS, PSPS1, PTP, REG
  • Links
    NCBI Gene ID: 5967
    neXtProt AC: NX_P05451

  • Chr Location
    2p12; chr2:79120458-79123419 (+)  GRCh38.p2

  • Human Ortholog
    REG1B, regenerating family member 1 beta
    Orthology source: HGNC
  • Synonyms
    PSPS2, REGH, REGI-BETA, REGL
  • Links
    NCBI Gene ID: 5968
    neXtProt AC: NX_P48304

  • Chr Location
    2p12; chr2:79085023-79088024 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Reg1
  • Incidental Mutations
Mice homozygous for a targeted null mutation appear normal. However, [3-H] thymidine incorporation into isolated pancreatic islets was reduced and GTG-induced islet hyperplasia was attenuated, suggesting a role for this gene in islet cell growth or regeneration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000057466 VEGA Gene Model | MGI Sequence Detail 5957 C57BL/6J ±  kb
transcript OTTMUST00000141341 VEGA | MGI Sequence Detail 904 Not Applicable  
polypeptide OTTMUSP00000073891 VEGA | MGI Sequence Detail 165 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    51 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 50
    Genomic 1
    cDNA 46
    Primer pair 1
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13830
References
more
  • Summaries
    All 37
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:19946 Terazono K, et al., A novel gene activated in regenerating islets. J Biol Chem. 1988 Feb 15;263(5):2111-4
  • Latest
    J:224160 Sun C, et al., Expression of Reg family genes in the gastrointestinal tract of mice treated with indomethacin. Am J Physiol Gastrointest Liver Physiol. 2015 May 1;308(9):G736-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory