About   Help   FAQ
Rad51 Gene Detail
Summary
  • Symbol
    Rad51
  • Name
    RAD51 recombinase
  • Synonyms
    Rad51a, Reca
  • Feature Type
    protein coding gene
  • IDs
    MGI:97890
    NCBI Gene: 19361
  • Gene Overview
    MyGene.info: RAD51
Location & Maps
more
  • Sequence Map
    Chr2:119112793-119147445 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34653 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 59.92 cM, cytoband F1
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    RAD51, RAD51 recombinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAD51, RAD51 recombinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BRCC5, FANCR, HRAD51, HsRad51, HsT16930, MRMV2, RAD51A, RECA
  • Links
    NCBI Gene ID: 5888
    neXtProt AC: NX_Q06609

  • Chr Location
    15q15.1; chr15:40694774-40732158 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human RAD51 associations

Human Disease Mouse Models
       Breast Cancer   OMIM: 114480
Mirror Movements 2; MRMV2   OMIM: 614508
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    42
  • Chemically induced (other)
    1
  • Gene trapped
    35
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Rad51
  • Incidental Mutations
Homozygotes for targeted null mutations die prior to implantation, usually by the eight-cell stage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015759 VEGA Gene Model | MGI Sequence Detail 34653 C57BL/6J ±  kb
transcript OTTMUST00000037427 VEGA | MGI Sequence Detail 3368 Not Applicable  
polypeptide OTTMUSP00000016772 VEGA | MGI Sequence Detail 339 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    193 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000013672 DNA repair protein RAD51 homolog 1
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR013632 DNA recombination and repair protein Rad51, C-terminal
    IPR016467 DNA recombination and repair protein, RecA-like
    IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
    IPR020587 DNA recombination and repair protein RecA, monomer-monomer interface
    IPR011941 DNA recombination/repair protein Rad51
    IPR010995 DNA repair Rad51/transcription factor NusA, alpha-helical
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 94
    Genomic 9
    cDNA 79
    Primer pair 5
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-13824, MGI:2139265
References
more
  • Summaries
    All 107
    Developmental Gene Expression 33
    Gene Ontology 34
    Phenotypes 13
  • Earliest
    J:12845 Shinohara A, et al., Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA [published erratum appears in Nat Genet 1993 Nov;5(3):312]. Nat Genet. 1993 Jul;4(3):239-43
  • Latest
    J:228047 Luo Y, et al., Hypersensitivity of primordial germ cells to compromised replication-associated DNA repair involves ATM-p53-p21 signaling. PLoS Genet. 2014 Jul;10(7):e1004471

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/15/2016
MGI 6.04
The Jackson Laboratory