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Rad51
Gene Detail
 Symbol
Name
ID
Rad51
RAD51 homolog
MGI:97890
Synonyms Rad51a, Reca
Feature Type protein coding gene
Genetic Map
Chromosome 2
59.92 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr2:119112793-119147445 bp, + strand
From VEGA annotation of GRCm38

  34653 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2155  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: DNA repair and recombination protein, Rad51 type
Gene Tree: Rad51

Human
homologs
Human Homolog RAD51, RAD51 recombinase
NCBI Gene ID 5888
neXtProt AC  NX_Q06609
Human Synonyms  BRCC5, HRAD51, HsRad51, HsT16930, MRMV2, RAD51A, RECA
Human Chr (Location)  15q15.1; chr15:40695129-40732158 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human RAD51
Mutations,
alleles, and
phenotypes
All mutations/alleles(40) : Gene trapped(35) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations die prior to implantation, usually by the eight-cell stage.
 
Interactions
Rad51 interacts with 274 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process ATP catabolic process, cellular response to camptothecin, ...
Component condensed chromosome, condensed nuclear chromosome, ...
Function ATP binding, damaged DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (27 records)
Data Summary: Results (118)    Tissues (21)    Images (20)
Theiler Stages: 10, 13, 20, 22, 23, 24
Assay TypeResults
RNA in situ 107
RT-PCR 11
cDNA source data(78)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(93) Genomic(9) cDNA(79) Primer pair(4) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000015759 (Evidence)
Ensembl Gene ModelENSMUSG00000027323 (Evidence)
Entrez Gene19361 (Evidence)
UniGene330492
DFCITC1576631, TC1604072, TC1613450
NIA Mouse Gene IndexU002303
Consensus CDS ProjectCCDS16590.1
International Mouse Knockout Project StatusRad51
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015759 VEGA Gene Model | MGI Sequence Detail 34653 C57BL/6J ±  kb
transcript OTTMUST00000037427 VEGA | MGI Sequence Detail 3368 Not Applicable 
polypeptide OTTMUSP00000016772 VEGA | MGI Sequence Detail 339 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(2) UniProt(4)
Polymorphisms RFLP(2) : SNPs within 2kb(204 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR013632 DNA recombination and repair protein Rad51, C-terminal
InterPro IPR016467 DNA recombination and repair protein, RecA-like
InterPro IPR011941 DNA recombination/repair protein Rad51
InterPro IPR020587 DNA recombination/repair protein RecA, monomer-monomer interface
InterPro IPR020588 DNA recombination/repair protein RecA/RadB, ATP-binding domain
InterPro IPR010995 DNA repair Rad51/transcription factor NusA, alpha-helical
InterPro IPR003583 Helix-hairpin-helix DNA-binding motif, class 1
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000013672 DNA repair protein RAD51 1
References (Earliest) J:12845 Shinohara A, et al., Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA [published erratum appears in Nat Genet 1993 Nov;5(3):312]. Nat Genet. 1993 Jul;4(3):239-43
(Latest) J:208416 Holt JE, et al., The APC/C activator FZR1 is essential for meiotic prophase I in mice. Development. 2014 Mar;141(6):1354-65
All references(98)
Other
accession IDs
MGD-MRK-13824, MGI:2139265

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory