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Rad51 Gene Detail
Summary
  • Symbol
    Rad51
  • Name
    RAD51 recombinase
  • Synonyms
    Rad51a, Reca
  • Feature Type
    protein coding gene
  • IDs
    MGI:97890
    NCBI Gene: 19361
  • Gene Overview
    MyGene.info: RAD51
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:119112793-119147445 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34653 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 59.92 cM, cytoband F1
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    RAD51, RAD51 recombinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAD51, RAD51 recombinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BRCC5, FANCR, HRAD51, HsRad51, HsT16930, MRMV2, RAD51A, RECA
  • Links
    NCBI Gene ID: 5888
    neXtProt AC: NX_Q06609
    UniProt: Q06609

  • Chr Location
    15q15.1; chr15:40694774-40732340 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human RAD51 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations die prior to implantation, usually by the eight-cell stage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000015759 VEGA Gene Model | MGI Sequence Detail 34653 C57BL/6J ±  kb
    transcript OTTMUST00000037427 VEGA | MGI Sequence Detail 3368 Not Applicable  
    polypeptide OTTMUSP00000016772 VEGA | MGI Sequence Detail 339 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      193 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000013672 DNA repair protein RAD51 homolog 1
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR013632 DNA recombination and repair protein Rad51-like, C-terminal
      IPR016467 DNA recombination and repair protein, RecA-like
      IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
      IPR020587 DNA recombination and repair protein RecA, monomer-monomer interface
      IPR011941 DNA recombination/repair protein Rad51
      IPR010995 DNA repair Rad51/transcription factor NusA, alpha-helical
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR033925 Rad51/DMC1/RadA
    Molecular
    Reagents
    less
    • All nucleic 95
      Genomic 9
      cDNA 80
      Primer pair 5
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13824, MGI:2139265
    References
    more
    • Summaries
      All 130
      Developmental Gene Expression 39
      Gene Ontology 37
      Phenotypes 13
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:263620 Zhou Z, et al., Pold3 is required for genomic stability and telomere integrity in embryonic stem cells and meiosis. Nucleic Acids Res. 2018 Apr 20;46(7):3468-3486

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory