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Rad51
Gene Detail
Symbol

Name
ID
Rad51
RAD51 homolog
MGI:97890
Synonyms
Rad51a, Reca
Feature Type
protein coding gene
Genetic Map
Chromosome 2
59.92 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr2:119112793-119147445 bp, + strand
From VEGA annotation of GRCm38

  34653 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2155  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RAD51
Protein SuperFamily: DNA repair and recombination protein, Rad51 type
Gene Tree: Rad51

Human
homologs
RAD51, RAD51 recombinase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5888
neXtProt AC: NX_Q06609

Human Synonyms: BRCC5, HRAD51, HsRad51, HsT16930, MRMV2, RAD51A, RECA

Human Chr (Location): 15q15.1; chr15:40694774-40732158 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human RAD51

Mutations,
alleles, and
phenotypes
All mutations/alleles(40) : Gene trapped(35) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations die prior to implantation, usually by the eight-cell stage.
 
Interactions
Rad51 interacts with 274 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (56 annotations)
Process cellular response to alkaloid, cellular response to camptothecin, ...
Component condensed chromosome, condensed nuclear chromosome, ...
Function ATP binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (32 records)
Data Summary: Results (126)    Tissues (28)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 107
RT-PCR 17
cDNA source data(78)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA RAD51 ; Xenbase rad51    NEW 
Molecular
reagents
All nucleic(94) Genomic(9) cDNA(79) Primer pair(5) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000015759 (Evidence)
Ensembl Gene Model ENSMUSG00000027323 (Evidence)
Entrez Gene 19361 (Evidence)
UniGene 330492
DFCI TC1576631, TC1613450, TC1604072
NIA Mouse Gene Index U002303
Consensus CDS Project CCDS16590.1
International Mouse Phenotyping Consortium Status Rad51
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015759 VEGA Gene Model | MGI Sequence Detail 34653 C57BL/6J ±  kb
transcript OTTMUST00000037427 VEGA | MGI Sequence Detail 3368 Not Applicable 
polypeptide OTTMUSP00000016772 VEGA | MGI Sequence Detail 339 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(2) : SNPs within 2kb(204 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR013632 DNA recombination and repair protein Rad51, C-terminal
InterPro IPR016467 DNA recombination and repair protein, RecA-like
InterPro IPR011941 DNA recombination/repair protein Rad51
InterPro IPR020587 DNA recombination/repair protein RecA, monomer-monomer interface
InterPro IPR020588 DNA recombination/repair protein RecA/RadB, ATP-binding domain
InterPro IPR010995 DNA repair Rad51/transcription factor NusA, alpha-helical
InterPro IPR003583 Helix-hairpin-helix DNA-binding motif, class 1
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000013672 DNA repair protein RAD51 homolog 1
References
(Earliest) J:12845 Shinohara A, et al., Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA [published erratum appears in Nat Genet 1993 Nov;5(3):312]. Nat Genet. 1993 Jul;4(3):239-43
(Latest) J:215796 Holloway JK, et al., Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites. J Cell Biol. 2014 Jun 9;205(5):633-41
All references(105)
Other
accession IDs
MGD-MRK-13824, MGI:2139265

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory