Rad51
Gene Detail

Symbol Name ID

Rad51 RAD51 homolog MGI:97890

Synonyms

Rad51a, Reca

Feature Type

protein coding gene

Genetic Map

Chromosome 2

59.92 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr2:119112793-119147445 bp, + strand From VEGA annotation of GRCm38   34653 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2155  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: DNA repair and recombination protein, Rad51 type
Gene Tree: Rad51

Human homologs

Human Homolog		RAD51, RAD51 homolog (S. cerevisiae)
NCBI Gene ID		5888
neXtProt AC		NX_Q06609
Human Synonyms		BRCC5, HRAD51, HsRad51, HsT16930, MRMV2, RAD51A, RECA
Human Chr (Location)		15q15.1; chr15:40987327-41024356 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human RAD51

Alleles and phenotypes

All alleles(40) : Targeted(5) Gene trapped(35)
 

Homozygotes for targeted null mutations die prior to implantation, usually by the eight-cell stage.

 

Gene Ontology (GO) classifications

All GO classifications: (39 annotations)

Process	DNA metabolic process, DNA recombination, ...
Component	condensed chromosome, condensed nuclear chromosome, ...
Function	ATP binding, damaged DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (24 records)
Data Summary: Results (116)    Tissues (20)    Images (20)
Theiler Stages: 10, 20, 22, 23, 24

Assay Type	Results
RNA in situ	107
RT-PCR	9

cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(33) Genomic(9) cDNA(20) Primer pair(3) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000015759 (Evidence)
Ensembl Gene Model	ENSMUSG00000027323 (Evidence)
Entrez Gene	19361 (Evidence)
DFCI	TC1576631, TC1604072, TC1613450
NIA Mouse Gene Index	U002303
Consensus CDS Project	CCDS16590.1
International Mouse Knockout Project Status	Rad51

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015759	VEGA Gene Model | MGI Sequence Detail	34653	C57BL/6J
transcript	OTTMUST00000037427	VEGA | MGI Sequence Detail	3368	Not Applicable
polypeptide	OTTMUSP00000016772	VEGA | MGI Sequence Detail	339	Not Applicable

All sequences(54) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(2) : SNPs(87 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003593	AAA+ ATPase domain
InterPro	IPR013632	DNA recombination and repair protein Rad51, C-terminal
InterPro	IPR016467	DNA recombination and repair protein, RecA-like
InterPro	IPR011941	DNA recombination/repair protein Rad51
InterPro	IPR020587	DNA recombination/repair protein RecA, monomer-monomer interface
InterPro	IPR020588	DNA recombination/repair protein RecA/RadB, ATP-binding domain
InterPro	IPR010995	DNA repair Rad51/transcription factor NusA, alpha-helical
InterPro	IPR003583	Helix-hairpin-helix DNA-binding motif, class 1
Protein Ontology	PR:000013672	DNA repair protein RAD51 1

References

(Earliest) J:12845 Shinohara A, et al., Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA [published erratum appears in Nat Genet 1993 Nov;5(3):312]. Nat Genet. 1993 Jul;4(3):239-43
(Latest) J:194101 Yamaguchi S, et al., Tet1 controls meiosis by regulating meiotic gene expression. Nature. 2012 Dec 20;492(7429):443-7
All references(91)

Other accession IDs

MGD-MRK-13824, MGI:2139265