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Rbp4 Gene Detail
Summary
  • Symbol
    Rbp4
  • Name
    retinol binding protein 4, plasma
  • Synonyms
    Rbp-4, retinol binding protein 4, cellular
  • Feature Type
    protein coding gene
  • IDs
    MGI:97879
    NCBI Gene: 19662
  • Gene Overview
    MyGene.info: RBP4
Location & Maps
more
  • Sequence Map
    Chr19:38116620-38125321 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8702 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RBP4, retinol binding protein 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RBP4, retinol binding protein 4
    Orthology source: HomoloGene
  • Synonyms
    MCOPCB10, RDCCAS
  • Links
    NCBI Gene ID: 5950
    neXtProt AC: NX_P02753

  • Chr Location
    10q23.33; chr10:93591836-93601236 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human RBP4 associations

Human Disease Mouse Models
       Microphthalmia, Isolated, with Coloboma 10; MCOPCB10   OMIM: 616428
Retinal Dystrophy, Iris Coloboma, and Comedogenic Acne Syndrome; RDCCAS   OMIM: 615147
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Gene trapped
    1
  • Targeted
    8
  • Incidental Mutations
    APF , CvDC
Homozygotes for a null allele show abnormal retinal function and retinol level, delayed heart trabeculation, and increased myocyte proliferation and fibronectin deposition in cardiac jelly and nascent valves. Homozygotes for another null allele show testicular defects on a vitamin A-deficient diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19662 NCBI Gene Model | MGI Sequence Detail 8702 C57BL/6J ±  kb
transcript NM_001159487 RefSeq | MGI Sequence Detail 1243 C57BL/6  
polypeptide Q00724 UniProt | EBI | MGI Sequence Detail 201 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    99 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 184
    cDNA 178
    Primer pair 4
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-13790, MGD-MRK-13795
References
more
  • Summaries
    All 79
    Developmental Gene Expression 12
    Gene Ontology 15
    Phenotypes 32
  • Earliest
    J:11060 Chainani M, et al., Localization of the gene for plasma retinol binding protein to the distal half of mouse chromosome 19. Genomics. 1991 Feb;9(2):376-9
  • Latest
    J:225452 Kraus BJ, et al., Novel role for retinol-binding protein 4 in the regulation of blood pressure. FASEB J. 2015 Aug;29(8):3133-40

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory