Rbp4
Gene Detail

Symbol Name ID

Rbp4 retinol binding protein 4, plasma MGI:97879

Synonyms

Rbp-4, retinol binding protein 4, cellular

Feature Type

protein coding gene

Genetic Map

Chromosome 19

32.75 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr19:38116620-38125321 bp, - strand From NCBI annotation of GRCm38   8702 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4908  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: lipocalin, ApoD type
Gene Tree: Rbp4

Human homologs

Human Homolog		RBP4, retinol binding protein 4, plasma
NCBI Gene ID		5950
neXtProt AC		NX_P02753
Human Synonyms		RDCCAS
Human Chr (Location)		10q23-q24; chr10:95351593-95360993 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human RBP4

Alleles and phenotypes

All alleles(7) : Targeted(6) Gene trapped(1)
 

Homozygotes for a null allele show abnormal retinal function and retinol level, delayed heart trabeculation, and increased myocyte proliferation and fibronectin deposition in cardiac jelly and nascent valves. Homozygotes for another null allele show testicular defects on a vitamin A-deficient diet.

 

Gene Ontology (GO) classifications

All GO classifications: (52 annotations)

Process	cardiac muscle tissue development, detection of light stimulus involved in visual perception, ...
Component	extracellular region, extracellular space, ...
Function	protein heterodimerization activity, retinal binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (76)    Tissues (38)    Images (36)
Theiler Stages: 19, 21, 22, 23, 26, 28

Assay Type	Results
RNA in situ	68
RT-PCR	8

cDNA source data(175)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(181) cDNA(177) Primer pair(2) Other(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000024990 (Evidence)
Entrez Gene	19662 (Evidence)
UniGene	2605
DFCI	TC1575169, TC1588956
DoTS	DT.101384743, DT.87072863
NIA Mouse Gene Index	U041230
Consensus CDS Project	CCDS29784.1, CCDS50430.1
International Mouse Knockout Project Status	Rbp4

Sequences

Length	Strain/Species
genomic	19662	NCBI Gene Model | MGI Sequence Detail	8702	C57BL/6J
transcript	NM_001159487	RefSeq | MGI Sequence Detail	1243	C57BL/6
polypeptide	Q00724	UniProt | EBI | MGI Sequence Detail	201	Not Applicable

All sequences(29) RefSeq(4) UniProt(3)

Polymorphisms

RFLP(3) : SNPs(44 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012674	Calycin
InterPro	IPR011038	Calycin-like
InterPro	IPR002345	Lipocalin
InterPro	IPR022271	Lipocalin, ApoD type
InterPro	IPR022272	Lipocalin conserved site
InterPro	IPR000566	Lipocalin/cytosolic fatty-acid binding protein domain
InterPro	IPR002449	Retinol-binding protein
Protein Ontology	PR:000013821	retinol-binding protein 4

Graphical View of Protein Domain Structure

References

(Earliest) J:11060 Chainani M, et al., Localization of the gene for plasma retinol binding protein to the distal half of mouse chromosome 19. Genomics. 1991 Feb;9(2):376-9
(Latest) J:186392 Wassef L, et al., beta-Carotene Supplementation Decreases Placental Transcription of LDL Receptor-Related Protein 1 in Wild-Type Mice and Stimulates Placental beta-Carotene Uptake in Marginally Vitamin A-Deficient Mice. J Nutr. 2012 Aug;142(8):1456-62
All references(70)

Other accession IDs

MGD-MRK-13790, MGD-MRK-13795