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Rbp4
Gene Detail
Symbol

Name
ID
Rbp4
retinol binding protein 4, plasma
MGI:97879
Synonyms
Rbp-4, retinol binding protein 4, cellular
Feature Type
protein coding gene
Genetic Map
Chromosome 19
32.75 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr19:38116620-38125321 bp, - strand
From NCBI annotation of GRCm38

  8702 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4908  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: lipocalin, ApoD type
Gene Tree: Rbp4

Human
homologs
Human Homolog RBP4, retinol binding protein 4, plasma
NCBI Gene ID 5950
neXtProt AC  NX_P02753
Human Synonyms  RDCCAS
Human Chr (Location)  10q23.33; chr10:93591836-93601344 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human RBP4
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from APF )
 
Homozygotes for a null allele show abnormal retinal function and retinol level, delayed heart trabeculation, and increased myocyte proliferation and fibronectin deposition in cardiac jelly and nascent valves. Homozygotes for another null allele show testicular defects on a vitamin A-deficient diet.
 
Interactions
Rbp4 interacts with 43 markers (Mir30a, Mir30d, Mir30e, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (12 records)
Data Summary: Results (76)    Tissues (38)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 68
RT-PCR 8
cDNA source data(175)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(181) cDNA(177) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000024990 (Evidence)
Entrez Gene19662 (Evidence)
UniGene2605
DFCITC1575169, TC1588956
DoTSDT.101384743, DT.87072863
NIA Mouse Gene IndexU041230
Consensus CDS ProjectCCDS29784.1, CCDS50430.1
International Mouse Knockout Project StatusRbp4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19662 NCBI Gene Model | MGI Sequence Detail 8702 C57BL/6J ±  kb
transcript NM_001159487 RefSeq | MGI Sequence Detail 1243 C57BL/6 
polypeptide Q00724 UniProt | EBI | MGI Sequence Detail 201 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(5)
Polymorphisms
RFLP(3) : SNPs within 2kb(100 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012674 Calycin
InterPro IPR011038 Calycin-like
InterPro IPR002345 Lipocalin
InterPro IPR022271 Lipocalin, ApoD type
InterPro IPR022272 Lipocalin conserved site
InterPro IPR000566 Lipocalin/cytosolic fatty-acid binding protein domain
InterPro IPR002449 Retinol binding protein/Purpurin
Protein Ontology PR:000013821 retinol-binding protein 4
Graphical View of Protein Domain Structure
References
(Earliest) J:11060 Chainani M, et al., Localization of the gene for plasma retinol binding protein to the distal half of mouse chromosome 19. Genomics. 1991 Feb;9(2):376-9
(Latest) J:210633 Moraes-Vieira PM, et al., RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance. Cell Metab. 2014 Mar 4;19(3):512-26
All references(79)
Other
accession IDs
MGD-MRK-13790, MGD-MRK-13795

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory