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Rbp3 Gene Detail
Summary
  • Symbol
    Rbp3
  • Name
    retinol binding protein 3, interstitial
  • Synonyms
    Irbp, Rbp-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:97878
    NCBI Gene: 19661
  • Gene Overview
    MyGene.info: RBP3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:33954022-33964216 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10195 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 20.80 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    RBP3, retinol binding protein 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RBP3, retinol binding protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    D10S64, D10S65, D10S66, IRBP, RBPI, RP66
  • Links
    NCBI Gene ID: 5949
    neXtProt AC: NX_P10745
    UniProt: P10745

  • Chr Location
    10q11.22; chr10:47348371-47357875 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human RBP3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene experience photoreceptor degeneration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19661 NCBI Gene Model | MGI Sequence Detail 10195 C57BL/6J ±  kb
    transcript NM_015745 RefSeq | MGI Sequence Detail 5298 C57BL/6  
    polypeptide P49194 UniProt | EBI | MGI Sequence Detail 1234 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      228 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR029045 ClpP/crotonase-like domain superfamily
      IPR032956 Retinol-binding protein 3
      IPR005151 Tail specific protease
    Molecular
    Reagents
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    • All nucleic 134
      Genomic 5
      cDNA 127
      Primer pair 1
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
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    MGD-MRK-11462, MGD-MRK-13789, MGD-MRK-13794
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 8
      Gene Ontology 5
      Phenotypes 19
    • Earliest
      J:12496 Kozak C, et al., Chromosome assignment in the mouse of the genes for several proteins involved in visual transduction. Cytogenet Cell Genet. 1989;51:1025-1026
    • Latest
      J:247034 Boldison J, et al., A novel pathogenic RBP-3 peptide reveals epitope spreading in persistent experimental autoimmune uveoretinitis. Immunology. 2015 Oct;146(2):301-11

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory