Rbp1
Gene Detail

Symbol Name ID

Rbp1 retinol binding protein 1, cellular MGI:97876

STS

D9Mit33

Synonyms

Crbp, CRBPI, Rbp-1

Feature Type

protein coding gene

Genetic Map

Chromosome 9

51.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr9:98422961-98446551 bp, + strand From NCBI annotation of GRCm38   23591 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2175  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 chicken; 1 zebrafish

Protein SuperFamily: lipid binding protein, FABP type
Gene Tree: Rbp1

Human homologs

Human Homolog		RBP1, retinol binding protein 1, cellular
NCBI Gene ID		5947
neXtProt AC		NX_P09455
Human Synonyms		CRABP-I, CRBP, CRBP1, CRBPI, RBPC
Human Chr (Location)		3q23; chr3:139236276-139258671 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Homozygotes for a targeted null mutation show increased susceptibility to a diet deficient in vitamin A. Mutants also exhibit a two-fold delay in dark adaptation after a photic flash.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	regulation of granulocyte differentiation, response to vitamin A, ...
Component	cell body, cytoplasm, ...
Function	lipid binding, retinal binding, ...

External Resources: FuncBase

Expression

Literature Summary: (48 records)
Data Summary: Results (399)    Tissues (229)    Images (111)
Theiler Stages: 9, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	31
RNA in situ	302
Northern blot	16
Western blot	2
RT-PCR	33
RNase protection	15

cDNA source data(87)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(100) Genomic(2) cDNA(93) Primer pair(4) Other(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000046402 (Evidence)
Entrez Gene	19659 (Evidence)
UniGene	279741
DFCI	TC1577152, TC1755112
DoTS	DT.534555, DT.94156550, DT.94156555
NIA Mouse Gene Index	U010894
Consensus CDS Project	CCDS23424.1
International Mouse Knockout Project Status	Rbp1

Sequences

Length	Strain/Species
genomic	19659	NCBI Gene Model | MGI Sequence Detail	23591	C57BL/6J
transcript	NM_011254	RefSeq | MGI Sequence Detail	2628	C57BL/6
polypeptide	Q00915	UniProt | EBI | MGI Sequence Detail	135	Not Applicable

All sequences(20) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(143 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012674	Calycin
InterPro	IPR011038	Calycin-like
InterPro	IPR000463	Cytosolic fatty-acid binding
InterPro	IPR000566	Lipocalin/cytosolic fatty-acid binding protein domain
Protein Ontology	PR:000013818	retinol-binding protein 1

Graphical View of Protein Domain Structure

References

(Earliest) J:8604 Demmer LA, et al., The cellular retinol binding protein II gene. Sequence analysis of the rat gene, chromosomal localization in mice and humans, and documentation of its close linkage to the cellular retinol binding protein gene. J Biol Chem. 1987 Feb 25;262(6):2458-67
(Latest) J:190746 Osuala K, et al., Physiological and genomic consequences of adrenergic deficiency during embryonic/fetal development in mice: impact on retinoic acid metabolism. Physiol Genomics. 2012 Oct 2;44(19):934-47
All references(99)

Other accession IDs

MGD-MRK-13787, MGD-MRK-13792, MGD-MRK-2131