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Rbp1
Gene Detail
Symbol

Name
ID
Rbp1
retinol binding protein 1, cellular
MGI:97876
STS
Synonyms
Crbp, CRBPI, Rbp-1
Feature Type
protein coding gene
Genetic Map
Chromosome 9
51.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr9:98422961-98446575 bp, + strand
From VEGA annotation of GRCm38

  23615 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2175  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: lipid binding protein, FABP type
Gene Tree: Rbp1

Human
homologs
Human Homolog RBP1, retinol binding protein 1, cellular
NCBI Gene ID 5947
neXtProt AC  NX_P09455
Human Synonyms  CRABP-I, CRBP, CRBP1, CRBPI, RBPC
Human Chr (Location)  3q23; chr3:139517434-139539829 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
 
Homozygotes for a targeted null mutation show increased susceptibility to a diet deficient in vitamin A. Mutants also exhibit a two-fold delay in dark adaptation after a photic flash.
 
Interactions
Rbp1 interacts with 22 markers (Mir137, Mir214, Mir292, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process regulation of granulocyte differentiation, response to vitamin A, ...
Component cell body, cytoplasm, ...
Function lipid binding, retinal binding, ...
External Resources: FuncBase
Expression
Literature Summary: (49 records)
Data Summary: Results (421)    Tissues (246)    Images (123)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 31
RNA in situ 324
Northern blot 16
Western blot 2
RT-PCR 33
RNase protection 15
cDNA source data(87)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(100) Genomic(2) cDNA(93) Primer pair(4) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000047579 (Evidence)
Ensembl Gene ModelENSMUSG00000046402 (Evidence)
Entrez Gene19659 (Evidence)
UniGene279741
DFCITC1577152, TC1755112
DoTSDT.534555, DT.94156550, DT.94156555
NIA Mouse Gene IndexU010894
Consensus CDS ProjectCCDS23424.1
International Mouse Knockout Project StatusRbp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047579 VEGA Gene Model | MGI Sequence Detail 23615 C57BL/6J ±  kb
transcript OTTMUST00000122708 VEGA | MGI Sequence Detail 2652 Not Applicable 
polypeptide OTTMUSP00000067225 VEGA | MGI Sequence Detail 135 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(339 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012674 Calycin
InterPro IPR011038 Calycin-like
InterPro IPR000463 Cytosolic fatty-acid binding
InterPro IPR000566 Lipocalin/cytosolic fatty-acid binding protein domain
Protein Ontology PR:000013818 retinol-binding protein 1
References
(Earliest) J:8604 Demmer LA, et al., The cellular retinol binding protein II gene. Sequence analysis of the rat gene, chromosomal localization in mice and humans, and documentation of its close linkage to the cellular retinol binding protein gene. J Biol Chem. 1987 Feb 25;262(6):2458-67
(Latest) J:204194 Wongsiriroj N, et al., Genetic dissection of retinoid esterification and accumulation in the liver and adipose tissue. J Lipid Res. 2014 Jan;55(1):104-14
All references(103)
Other
accession IDs
MGD-MRK-13787, MGD-MRK-13792, MGD-MRK-2131

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory