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Rbp1 Gene Detail
Summary
  • Symbol
    Rbp1
  • Name
    retinol binding protein 1, cellular
  • Synonyms
    Crbp, CRBPI, Rbp-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97876
    NCBI Gene: 19659
  • Gene Overview
    MyGene.info: RBP1
Location & Maps
more
  • Sequence Map
    Chr9:98422961-98446575 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23615 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 51.36 cM
  • Mapping Data
    11 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    RBP1, retinol binding protein 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RBP1, retinol binding protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CRABP-I, CRBP, CRBP1, CRBPI, RBPC
  • Links
    NCBI Gene ID: 5947
    neXtProt AC: NX_P09455

  • Chr Location
    3q23; chr3:139517434-139539829 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 1 allele in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Rbp1
Homozygotes for a targeted null mutation show increased susceptibility to a diet deficient in vitamin A. Mutants also exhibit a two-fold delay in dark adaptation after a photic flash.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047579 VEGA Gene Model | MGI Sequence Detail 23615 C57BL/6J ±  kb
transcript OTTMUST00000122708 VEGA | MGI Sequence Detail 2652 Not Applicable  
polypeptide OTTMUSP00000067225 VEGA | MGI Sequence Detail 135 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    328 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 100
    Genomic 2
    cDNA 93
    Primer pair 4
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-13787, MGD-MRK-13792, MGD-MRK-2131
References
more
  • Summaries
    All 103
    Developmental Gene Expression 49
    Gene Ontology 8
    Phenotypes 21
  • Earliest
    J:8604 Demmer LA, et al., The cellular retinol binding protein II gene. Sequence analysis of the rat gene, chromosomal localization in mice and humans, and documentation of its close linkage to the cellular retinol binding protein gene. J Biol Chem. 1987 Feb 25;262(6):2458-67
  • Latest
    J:224771 Ruhl R, et al., 9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice. PLoS Genet. 2015 Jun;11(6):e1005213

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory