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Rbp1 Gene Detail
Summary
  • Symbol
    Rbp1
  • Name
    retinol binding protein 1, cellular
  • Synonyms
    Crbp, CRBPI, Rbp-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97876
    NCBI Gene: 19659
  • Gene Overview
    MyGene.info: RBP1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:98422961-98446551 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 51.36 cM
  • Mapping Data
    11 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    328 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97876
protein coding gene Chr9:98422961-98446575 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035154
protein coding gene Chr9:99724425-99751750 (+)
A/J MGP_AJ_G0035136
protein coding gene Chr9:96220623-96244183 (+)
AKR/J MGP_AKRJ_G0035067
protein coding gene Chr9:98566488-98591424 (+)
BALB/cJ MGP_BALBcJ_G0035128
protein coding gene Chr9:95901538-95925957 (+)
C3H/HeJ MGP_C3HHeJ_G0034838
protein coding gene Chr9:98964659-98990232 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035648
protein coding gene Chr9:102565788-102592295 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032547
protein coding gene Chr9:93993254-94016533 (+)
CAST/EiJ MGP_CASTEiJ_G0034149
protein coding gene Chr9:98770991-98794841 (+)
CBA/J MGP_CBAJ_G0034806
protein coding gene Chr9:106106795-106136924 (+)
DBA/2J MGP_DBA2J_G0034968
protein coding gene Chr9:95735369-95759493 (+)
FVB/NJ MGP_FVBNJ_G0034916
protein coding gene Chr9:94566447-94590519 (+)
LP/J MGP_LPJ_G0035047
protein coding gene Chr9:99976595-100002945 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034955
protein coding gene Chr9:108053835-108078711 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035670
protein coding gene Chr9:98789829-98814652 (+)
PWK/PhJ MGP_PWKPhJ_G0033856
protein coding gene Chr9:95937167-95961119 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033692
protein coding gene Chr9:98851017-98877411 (+)
WSB/EiJ MGP_WSBEiJ_G0034269
protein coding gene Chr9:98674345-98699808 (+)



Homology
more
  • Human Ortholog
    RBP1, retinol binding protein 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RBP1, retinol binding protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CRABP-I, CRBP, CRBP1, CRBPI, RBPC
  • Links
    NCBI Gene ID: 5947
    neXtProt AC: NX_P09455
    UniProt: P09455

  • Chr Location
    3q23; chr3:139517434-139539829 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 3 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation show increased susceptibility to a diet deficient in vitamin A. Mutants also exhibit a two-fold delay in dark adaptation after a photic flash.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19659 NCBI Gene Model | MGI Sequence Detail 23591 C57BL/6J ±  kb
    transcript NM_011254 RefSeq | MGI Sequence Detail 2628 C57BL/6  
    polypeptide Q00915 UniProt | EBI | MGI Sequence Detail 135 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 101
      Genomic 2
      cDNA 94
      Primer pair 4
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13787, MGD-MRK-13792, MGD-MRK-2131
    References
    more
    • Summaries
      All 114
      Developmental Gene Expression 53
      Gene Ontology 9
      Phenotypes 22
    • Earliest
      J:8604 Demmer LA, et al., The cellular retinol binding protein II gene. Sequence analysis of the rat gene, chromosomal localization in mice and humans, and documentation of its close linkage to the cellular retinol binding protein gene. J Biol Chem. 1987 Feb 25;262(6):2458-67
    • Latest
      J:253627 Luo F, et al., Efficient stimulus-secretion coupling at ribbon synapses requires RIM-binding protein tethering of L-type Ca(2+) channels. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E8081-E8090

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    09/10/2019
    MGI 6.14
    The Jackson Laboratory