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Rarg Gene Detail
Summary
  • Symbol
    Rarg
  • Name
    retinoic acid receptor, gamma
  • Synonyms
    MGC:11555, MGC:18523, RARgamma2, RAR gamma 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97858
    NCBI Gene: 19411
  • Gene Overview
    MyGene.info: RARG
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr15:102234938-102257517 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      22580 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 57.40 cM, cytoband E-F3
  • Mapping Data
    14 experiments
Homology
more
  • Human Ortholog
    RARG, retinoic acid receptor gamma
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RARG, retinoic acid receptor gamma
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NR1B3, RARC
  • Links
    NCBI Gene ID: 5916
    neXtProt AC: NX_P13631
    UniProt: P13631

  • Chr Location
    12q13.13; chr12:53210566-53232256 (-)  GRCh38.p7
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 6 alleles in 7 genetic backgrounds
    100 phenotypes from multigenic genotypes
    74 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit stunted growth, homeotic transformations of the rostral axial skeleton and tracheal cartilage, Harderian gland agenesis, high postnatal mortality, and male sterility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    93
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    985
  • Tissues
    456
  • cDNA Data
    79
  • Literature Summary
    85
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000029220 VEGA Gene Model | MGI Sequence Detail 22580 C57BL/6J ±  kb
    transcript OTTMUST00000072430 VEGA | MGI Sequence Detail 2953 Not Applicable  
    polypeptide OTTMUSP00000037288 VEGA | MGI Sequence Detail 458 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      138 from dbSNP Build 142
    • RFLP
      7
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 102
      Genomic 2
      cDNA 87
      Primer pair 12
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13768, MGI:2145988
    References
    more
    • Summaries
      All 241
      Developmental Gene Expression 85
      Diseases 1
      Gene Ontology 24
      Phenotypes 74
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/09/2018
    MGI 6.12     		The Jackson Laboratory