Rarg MGI Mouse Gene Detail - MGI:97858 - retinoic acid receptor, gamma

Rarg Gene Detail

Symbol

Rarg
Name

retinoic acid receptor, gamma
Synonyms

MGC:11555, MGC:18523, RARgamma2, RAR gamma 2

Feature Type

protein coding gene
IDs

MGI:97858
NCBI Gene: 19411
Gene Overview

MyGene.info: RARG
Alliance

gene page

Sequence Map

Chr15:102234938-102257517 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

22580 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 57.40 cM, cytoband E-F3
Mapping Data

14 experiments

Human Ortholog

RARG, retinoic acid receptor gamma

Vertebrate Orthologs

9

Human Ortholog

RARG, retinoic acid receptor gamma
Orthology source: HomoloGene, HGNC
Synonyms

NR1B3, RARC
Links

HGNC:9866

NCBI Gene ID: 5916

neXtProt AC: NX_P13631

UniProt: P13631
Chr Location

12q13.13; chr12:53210566-53232256 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 20263
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: RARG
Protein SuperFamily

retinoic acid receptor
Gene Tree

Rarg

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References

1 with disease annotations

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Phenotype Summary

42 phenotypes from 6 alleles in 7 genetic backgrounds
100 phenotypes from multigenic genotypes
74 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

244
Chemically induced (other)

1
Gene trapped

232
Radiation induced

2
Targeted

9
Genomic Mutations

3 involving Rarg
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

158 strains or lines available

Homozygotes for targeted null mutations exhibit stunted growth, homeotic transformations of the rostral axial skeleton and tracheal cartilage, Harderian gland agenesis, high postnatal mortality, and male sterility.

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All GO Annotations

75
GO References

23

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

966
Tissues

444
cDNA Data

79
Literature Summary

82

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rarg

ZFIN rarga, rargb

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Rarg interacts with 230 markers (Mir7-1, Mir9-1, Mir9-2, ...) View All

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All Sequences

48
RefSeq

8
UniProt

2
CCDS

CCDS27875.1, CCDS37226.1
UniGene

1273

			Length	Strain/Species	Flank
genomic	OTTMUSG00000029220	VEGA Gene Model \| MGI Sequence Detail	22580	C57BL/6J	± kb
transcript	OTTMUST00000072430	VEGA \| MGI Sequence Detail	2953	Not Applicable
polypeptide	OTTMUSP00000037288	VEGA \| MGI Sequence Detail	458	Not Applicable

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SNPs within 2kb

138 from dbSNP Build 142

RFLP

7

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UniProt

2 Sequences
Protein Ontology

PR:000013738 retinoic acid receptor gamma

(term hierarchy)
InterPro Domains

IPR001723 Nuclear hormone receptor

IPR000536 Nuclear hormone receptor, ligand-binding domain

IPR035500 Nuclear hormone receptor-like domain superfamily

IPR003078 Retinoic acid receptor

IPR013088 Zinc finger, NHR/GATA-type

IPR001628 Zinc finger, nuclear hormone receptor-type

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All nucleic 102

Genomic 2

cDNA 87

Primer pair 12

Other 1

Microarray probesets 4

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MGD-MRK-13768, MGI:2145988

Summaries

All 237

Developmental Gene Expression 82

Diseases 1

Gene Ontology 23

Phenotypes 74
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:246472 Lee LM, et al., Perturbation of Retinoid Homeostasis Increases Malformation Risk in Embryos Exposed to Pregestational Diabetes. Diabetes. 2017 Apr;66(4):1041-1051

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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