Rarg
Gene Detail

Symbol

Name
ID

Rarg
retinoic acid receptor, gamma
MGI:97858

Synonyms

MGC:11555, MGC:18523, RARgamma2, RAR gamma 2

Feature Type

protein coding gene

Genetic Map

Chromosome 15
57.40 cM, cytoband E-F3
Detailed Genetic Map ± 1 cM


Mapping data(14)

Sequence Map

Chr15:102234938-102257517 bp, - strand From VEGA annotation of GRCm38   22580 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:20263  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: retinoic acid receptor
Gene Tree: Rarg

Human
homologs

Human Homolog		RARG, retinoic acid receptor, gamma
NCBI Gene ID		5916
neXtProt AC		NX_P13631
Human Synonyms		NR1B3, RARC
Human Chr (Location)		12q13; chr12:53210566-53232256 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(242) : Gene trapped(232) Radiation induced(1) Targeted(9)
Genomic Mutations involving Rarg (1)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygotes for targeted null mutations exhibit stunted growth, homeotic transformations of the rostral axial skeleton and tracheal cartilage, Harderian gland agenesis, high postnatal mortality, and male sterility.

 
Phenotype Images(2)

Interactions

Rarg interacts with 230 markers (Mir7-1, Mir9-1, Mir9-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (74 annotations)

Process	anterior/posterior pattern specification, bone development, ...
Component	nuclear chromatin, nucleoplasm, ...
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (74 records)

Data Summary: Results (858)    Tissues (362)    Images (140)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	577
Northern blot	92
Western blot	14
RT-PCR	107
RNase protection	68

cDNA source data(77)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(100) Genomic(2) cDNA(85) Primer pair(12) Other(1)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000029220 (Evidence)
Ensembl Gene Model	ENSMUSG00000001288 (Evidence)
Entrez Gene	19411 (Evidence)
UniGene	1273
DFCI	TC1581855, TC1641167, TC1658895, TC1690872
DoTS	DT.55165717, DT.87040403, DT.94147887, DT.94147888, DT.97359779
NIA Mouse Gene Index	U036693, U322973
Consensus CDS Project	CCDS27875.1, CCDS37226.1
International Mouse Knockout Project Status	Rarg

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029220	VEGA Gene Model | MGI Sequence Detail	22580	C57BL/6J
transcript	OTTMUST00000072430	VEGA | MGI Sequence Detail	2953	Not Applicable
polypeptide	OTTMUSP00000037288	VEGA | MGI Sequence Detail	458	Not Applicable

All sequences(59) RefSeq(8) UniProt(3)

Polymorphisms

RFLP(7) : SNPs within 2kb(183 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR003078	Retinoic acid receptor
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000013738	retinoic acid receptor gamma

References

(Earliest) J:9853 Harada M, et al., Strain difference and mode of inheritance of the susceptibility to passive cutaneous anaphylaxis mediated by allogeneic IgE antibody in the mouse. Immunol Invest. 1989 Jun;18(5):723-35
(Latest) J:214109 Adams MK, et al., The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis. J Biol Chem. 2014 May 23;289(21):14868-80
All references(203)

Other
accession IDs

MGD-MRK-13768, MGI:2145988