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Rarb Gene Detail
Summary
  • Symbol
    Rarb
  • Name
    retinoic acid receptor, beta
  • Synonyms
    Hap, RARbeta2, RAR beta 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97857
    NCBI Gene: 218772
  • Gene Overview
    MyGene.info: RARB
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:16430839-16819156 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      388318 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 7.08 cM, cytoband A1-A3
  • Mapping Data
    21 experiments
Homology
more
  • Human Ortholog
    RARB, retinoic acid receptor beta
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RARB, retinoic acid receptor beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HAP, MCOPS12, NR1B2, RARbeta1, RRB2
  • Links
    NCBI Gene ID: 5915
    neXtProt AC: NX_P10826
    UniProt: P10826

  • Chr Location
    3p24.2; chr3:24829323-25597932 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 4 alleles in 4 genetic backgrounds
    114 phenotypes from multigenic genotypes
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced growth, but are otherwise normal. Rarb/Rara double knockouts exhibit impaired vitamin A signaling and develop urogenital malformations, including renal hypoplasia and hydronephrosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017491 Ensembl Gene Model | MGI Sequence Detail 388318 C57BL/6J ±  kb
    transcript ENSMUST00000063750 Ensembl | MGI Sequence Detail 3108 Not Applicable  
    polypeptide ENSMUSP00000067694 Ensembl | MGI Sequence Detail 448 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      7010 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 96
      Genomic 5
      cDNA 77
      Primer pair 11
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10620, MGD-MRK-13767
    References
    more
    • Summaries
      All 272
      Developmental Gene Expression 125
      Gene Ontology 20
      Phenotypes 51
    • Earliest
      J:22881 de The H, et al., A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma. Nature. 1987 Dec 17-23;330(6149):667-70
    • Latest
      J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory