About   Help   FAQ
Rarb Gene Detail
Summary
  • Symbol
    Rarb
  • Name
    retinoic acid receptor, beta
  • Synonyms
    Hap, RARbeta2, RAR beta 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97857
    NCBI Gene: 218772
  • Gene Overview
    MyGene.info: RARB
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:16430839-16819156 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      388318 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 7.08 cM, cytoband A1-A3
  • Mapping Data
    21 experiments
Homology
more
  • Human Ortholog
    RARB, retinoic acid receptor beta
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RARB, retinoic acid receptor beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HAP, MCOPS12, NR1B2, RARbeta1, RRB2
  • Links
    NCBI Gene ID: 5915
    neXtProt AC: NX_P10826
    UniProt: P10826

  • Chr Location
    3p24.2; chr3:24829323-25597932 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 4 alleles in 4 genetic backgrounds
    114 phenotypes from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced growth, but are otherwise normal. Rarb/Rara double knockouts exhibit impaired vitamin A signaling and develop urogenital malformations, including renal hypoplasia and hydronephrosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000017491 Ensembl Gene Model | MGI Sequence Detail 388318 C57BL/6J ±  kb
transcript ENSMUST00000063750 Ensembl | MGI Sequence Detail 3108 Not Applicable  
polypeptide ENSMUSP00000067694 Ensembl | MGI Sequence Detail 448 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    7010 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 95
    Genomic 5
    cDNA 76
    Primer pair 11
    Other 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10620, MGD-MRK-13767
References
more
  • Summaries
    All 266
    Developmental Gene Expression 122
    Gene Ontology 19
    Phenotypes 50
  • Earliest
    J:22881 de The H, et al., A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma. Nature. 1987 Dec 17-23;330(6149):667-70
  • Latest
    J:244957 El Shahawy M, et al., Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid. PLoS Genet. 2017 Jul;13(7):e1006914

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/17/2018
MGI 6.11
The Jackson Laboratory