About   Help   FAQ
Rarb
Gene Detail
Symbol

Name
ID
Rarb
retinoic acid receptor, beta
MGI:97857
Synonyms
Hap, RARbeta2, RAR beta 2
Feature Type
protein coding gene
Genetic Map
Chromosome 14
7.08 cM, cytoband A1-A3
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr14:16430839-16575210 bp, - strand
From NCBI annotation of GRCm38

  144372 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68100  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Rarb

Human
homologs
Human Homolog RARB, retinoic acid receptor, beta
NCBI Gene ID 5915
neXtProt AC  NX_P10826
Human Synonyms  HAP, MCOPS12, NR1B2, RRB2
Human Chr (Location)  3p24.2; chr3:25428263-25597932 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human RARB
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit reduced growth, but are otherwise normal. Rarb/Rara double knockouts exhibit impaired vitamin A signaling and develop urogenital malformations, including renal hypoplasia and hydronephrosis.
 
Interactions
Rarb interacts with 295 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process bone development, embryonic digestive tract development, ...
Component nucleus
Function DNA binding, drug binding, ...
External Resources: FuncBase
Expression
Literature Summary: (110 records)
Data Summary: Results (757)    Tissues (341)    Images (158)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 588
Northern blot 73
Western blot 12
RT-PCR 36
RNase protection 48
cDNA source data(60)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(92) Genomic(5) cDNA(73) Primer pair(11) Other(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000017491 (Evidence)
Entrez Gene218772 (Evidence)
UniGene259318
DFCITC1578567, TC1607209, TC1660695
PDB1XDK
Consensus CDS ProjectCCDS26834.1
International Mouse Knockout Project StatusRarb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 218772 NCBI Gene Model | MGI Sequence Detail 144372 C57BL/6J ±  kb
transcript NM_001289760 RefSeq | MGI Sequence Detail 3158 C57BL/6 
polypeptide P22605 UniProt | EBI | MGI Sequence Detail 482 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(10) UniProt(2)
Polymorphisms
RFLP(8) : SNPs within 2kb(1529 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR003078 Retinoic acid receptor
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000013737 retinoic acid receptor beta
Graphical View of Protein Domain Structure
References
(Earliest) J:22881 de The H, et al., A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma. Nature. 1987 Dec 17-23;330(6149):667-70
(Latest) J:210244 Guo Y, et al., Dissecting the role of retinoic acid receptor isoforms in the CD8 response to infection. J Immunol. 2014 Apr 1;192(7):3336-44
All references(245)
Other
accession IDs
MGD-MRK-10620, MGD-MRK-13767

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory