Rarb MGI Mouse Gene Detail - MGI:97857 - retinoic acid receptor, beta

Symbol

Rarb
Name

retinoic acid receptor, beta
Synonyms

Hap, RAR beta 2, RARbeta2

Feature Type

protein coding gene
IDs

MGI:97857
NCBI Gene: 218772
Alliance

genome feature page
Transcription Start Sites

10 TSS

Sequence Map

Chr14:5650540-6038924 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 7.08 cM, cytoband A1-A3
Mapping Data

21 experiments

SNPs within 2kb

10903 from dbSNP Build 142
Strain Annotations

19
RFLP

8

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97857	protein coding gene	Chr14:5387365-6038924 (+)
129S1/SvImJ	ENSMUSG00200023832	protein coding gene	Chr14:2231460-2602539 (+)
A/J	ENSMUSG00195029622	protein coding gene	Chr14:3112065-3498438 (+)
AKR/J	ENSMUSG00220023168	protein coding gene	Chr14:2262075-2648810 (+)
BALB/cJ	ENSMUSG00180022839	protein coding gene	Chr14:2425469-2808345 (+)
C3H/HeJ	ENSMUSG00175009244	protein coding gene	Chr14:2389025-2760128 (+)
C57BL/6NJ	ENSMUSG00215012503	protein coding gene	Chr14:2686659-3075351 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018970	protein coding gene	Chr14:9411797-9544050 (-)
CAST/EiJ	ENSTCUG00005029352	protein coding gene	Chr14:2412865-2781252 (+)
CBA/J	ENSMUSG00210032748	protein coding gene	Chr14:2610539-2981649 (+)
DBA/2J	ENSMUSG00185035656	protein coding gene	Chr14:2616144-2987314 (+)
FVB/NJ	ENSMUSG00205021237	protein coding gene	Chr14:2647482-3036160 (+)
JF1/MsJ	ENSUMUG00000020367	protein coding gene	Chr14:2614206-2985113 (+)
LP/J	ENSMUSG00230006632	protein coding gene	Chr14:3745560-4116630 (+)
NOD/ShiLtJ	ENSMUSG00190030692	protein coding gene	Chr14:2684212-3070531 (+)
NZO/HlLtJ	ENSMUSG00225036884	protein coding gene	Chr14:3094161-3482396 (+)
PWK/PhJ	ENSLUMG00010030522	protein coding gene	Chr14:23957783-24328872 (+)
SPRET/EiJ	ENSMSPG00010002328	protein coding gene	Chr14:2765570-3149170 (+)
WSB/EiJ	ENSIUOG00005023370	protein coding gene	Chr14:2478532-2873577 (+)

Human Ortholog

RARB, retinoic acid receptor beta

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RARB, retinoic acid receptor beta
Synonyms

HAP, MCOPS12, NR1B2, RARbeta, RARbeta1, RRB2
Links

HGNC:9865

NCBI Gene ID: 5915

UniProt: P10826
Chr Location

3p24.2; chr3:24687887-25597932 (+) GRCh38

MGI Vertebrate Homology

Rarb stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: RARB
Gene Tree

Rarb

Diseases

5 with human RARB associations

				Human Disease	Mouse Models
				asbestos-related lung carcinoma IDs asbestos-related lung carcinoma DOID:7596 NCI:C27925 UMLS_CUI:C1332337
				lung adenocarcinoma IDs lung adenocarcinoma DOID:3910 DOID:4826 EFO:0000571 MESH:D000077192 NCI:C27745 NCI:C3512 UMLS_CUI:C0152013 UMLS_CUI:C1335060
				lung non-small cell carcinoma IDs lung non-small cell carcinoma DOID:3908 EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 UMLS_CUI:C0007131
				lung small cell carcinoma IDs lung small cell carcinoma DOID:5409 KEGG:05222 MESH:D055752 NCI:C4917 OMIM:182280 UMLS_CUI:C0149925
				syndromic microphthalmia 12 IDs syndromic microphthalmia 12 DOID:0111800 OMIM:615524

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

39 phenotypes from 5 alleles in 5 genetic backgrounds
127 phenotypes from multigenic genotypes
70 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

6
Gene trapped

1
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygotes for a targeted null mutation exhibit reduced growth, but are otherwise normal. Rarb/Rara double knockouts exhibit impaired vitamin A signaling and develop urogenital malformations, including renal hypoplasia and hydronephrosis.

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All GO Annotations

86
GO References

25

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1666
Tissues

502
cDNA Data

65
Literature Summary

164

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA RARB

Xenbase rarb

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All Sequences

60
RefSeq

8
UniProt

7
CCDS

CCDS26834.1

Ensembl

ENSMUSG00000017491 (Evidence)
NCBI Gene

218772

			Length	Strain/Species	Flank
genomic	ENSMUSG00000017491	Ensembl Gene Model \| MGI Sequence Detail	388385	C57BL/6J	± kb
transcript	ENSMUST00000063750	Ensembl \| MGI Sequence Detail	3108	Not Applicable
polypeptide	ENSMUSP00000067694	Ensembl \| MGI Sequence Detail	448	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000013737 retinoic acid receptor beta

(term hierarchy)
PDB

1XDK
InterPro Domains

IPR001723 Nuclear hormone receptor

IPR000536 Nuclear hormone receptor, ligand-binding domain

IPR035500 Nuclear hormone receptor-like domain superfamily

IPR003078 Retinoic acid receptor

IPR047159 Retinoic acid receptor, DNA-binding domain

IPR047158 Retinoic acid receptor, ligand-binding domain

IPR013088 Zinc finger, NHR/GATA-type

IPR001628 Zinc finger, nuclear hormone receptor-type

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All nucleic 138

Genomic 5

cDNA 82

Primer pair 23

Other 28

Antibodies 5

Microarray probesets 3

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MGD-MRK-10620, MGD-MRK-13767

Summaries

All 341

Developmental Gene Expression 164

Gene Ontology 25

Phenotypes 70
Earliest

J:22881 de The H, et al., A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma. Nature. 1987 Dec 17-23;330(6149):667-70
Latest

J:391359 Palhazi B, et al., The absence of Trim28 in nephron progenitors results in impaired kidney development and function. Development. 2026 Aug 1;153(15):dev205188

TSS for Rarb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr127520	Chr14:5894204-5894225 (+)	243,675 bp
Tssr127519	Chr14:5894234-5894255 (+)	243,705 bp
Tssr127518	Chr14:5894262-5894307 (+)	243,745 bp
Tssr127517	Chr14:5894351-5894399 (+)	243,835 bp
Tssr127516	Chr14:5894402-5894420 (+)	243,871 bp
Tssr127515	Chr14:5894593-5894606 (+)	244,060 bp
Tssr127514	Chr14:5894702-5894728 (+)	244,175 bp
Tssr127513	Chr14:5978668-5978680 (+)	328,134 bp
Tssr127512	Chr14:6003051-6003054 (+)	352,513 bp
Tssr127511	Chr14:6022658-6022674 (+)	372,126 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24