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Rarb Gene Detail
Summary
  • Symbol
    Rarb
  • Name
    retinoic acid receptor, beta
  • Synonyms
    Hap, RARbeta2, RAR beta 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97857
    NCBI Gene: 218772
Location & Maps
more
  • Sequence Map
    Chr14:16430842-16575472 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      144631 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RARB, retinoic acid receptor, beta
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RARB, retinoic acid receptor, beta
    Orthology source: HomoloGene
  • Synonyms
    HAP, MCOPS12, NR1B2, RRB2
  • Links
    NCBI Gene ID: 5915
    neXtProt AC: NX_P10826

  • Chr Location
    3p24.2; chr3:25174332-25597932 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human RARB associations

Human Disease Mouse Models
       Microphthalmia, Syndromic 12; MCOPS12   OMIM: 615524
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 4 alleles in 4 genetic backgrounds
    112 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced growth, but are otherwise normal. Rarb/Rara double knockouts exhibit impaired vitamin A signaling and develop urogenital malformations, including renal hypoplasia and hydronephrosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000017491 Ensembl Gene Model | MGI Sequence Detail 144631 C57BL/6J ±  kb
transcript ENSMUST00000063750 Ensembl | MGI Sequence Detail 3034 Not Applicable  
polypeptide ENSMUSP00000067694 Ensembl | MGI Sequence Detail 448 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1533 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000013737 retinoic acid receptor beta
  • PDB
  • InterPro Domains
    IPR001723 Nuclear hormone receptor
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR003078 Retinoic acid receptor
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
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  • All nucleic 92
    Genomic 5
    cDNA 73
    Primer pair 11
    Other 3

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-10620, MGD-MRK-13767
References
more
  • Summaries
    All 246
    Developmental Gene Expression 115
    Gene Ontology 19
    Phenotypes 46
  • Earliest
    J:22881 de The H, et al., A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma. Nature. 1987 Dec 17-23;330(6149):667-70
  • Latest
    J:226683 Rataj-Baniowska M, et al., Retinoic Acid Receptor beta Controls Development of Striatonigral Projection Neurons through FGF-Dependent and Meis1-Dependent Mechanisms. J Neurosci. 2015 Oct 28;35(43):14467-75

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory