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Rab3a
Gene Detail
Symbol

Name
ID
Rab3a
RAB3A, member RAS oncogene family
MGI:97843
Feature Type
protein coding gene
Genetic Map
Chromosome 8
34.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:70754679-70758677 bp, + strand
From VEGA annotation of GRCm38

  3999 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20629  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rab3a

Human
homologs
Human Homolog RAB3A, RAB3A, member RAS oncogene family
NCBI Gene ID 5864
neXtProt AC  NX_P20336
Human Chr (Location)  19p13.2; chr19:18196801-18204064 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants show impaired synaptic transmission, insulin secretion and glucose intolerance. This mutation and another chemically induced allele affect circadian period and sleep patterns. Heterozygotes show milder circadian rhythm anomalies.
 
Interactions
Rab3a interacts with 73 markers (Mir15a, Mir15b, Mir92-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (59 annotations)
Process axonogenesis, exocytosis, ...
Component acrosomal vesicle, axon, ...
Function ATPase activator activity, ATPase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (19)    Tissues (15)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 13
RNA in situ 3
Western blot 3
cDNA source data(78)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(80) Genomic(2) cDNA(78)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000016949 (Evidence)
Ensembl Gene ModelENSMUSG00000031840 (Evidence)
Entrez Gene19339 (Evidence)
UniGene5083
DFCITC1574121, TC1624230
DoTSDT.110853509, DT.533094, DT.94361216
NIA Mouse Gene IndexU009442
Consensus CDS ProjectCCDS22379.1
International Mouse Knockout Project StatusRab3a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016949 VEGA Gene Model | MGI Sequence Detail 3999 C57BL/6J ±  kb
transcript OTTMUST00000041120 VEGA | MGI Sequence Detail 1375 Not Applicable 
polypeptide OTTMUSP00000018420 VEGA | MGI Sequence Detail 220 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(10) UniProt(7)
Polymorphisms
SNPs within 2kb(11 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003579 Small GTPase superfamily, Rab type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013617 ras-related protein Rab-3A
References
(Earliest) J:13259 Baumert M, et al., Structure of the murine rab3A gene: correlation of genomic organization with antibody epitopes. Biochem J. 1993 Jul 1;293(Pt 1):157-63
(Latest) J:204165 Feliciano P, et al., Synapsin II and Rab3a cooperate in the regulation of epileptic and synaptic activity in the CA1 region of the hippocampus. J Neurosci. 2013 Nov 13;33(46):18319-30
All references(92)
Other
accession IDs
MGD-MRK-13746

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory