Rab3a
Gene Detail

Symbol Name ID

Rab3a RAB3A, member RAS oncogene family MGI:97843

Feature Type

protein coding gene

Genetic Map

Chromosome 8

34.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr8:70754679-70758677 bp, + strand From VEGA annotation of GRCm38   3999 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20629  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rab3a

Human homologs

Human Homolog		RAB3A, RAB3A, member RAS oncogene family
NCBI Gene ID		5864
neXtProt AC		NX_P20336
Human Chr (Location)		19p13.2; chr19:18196801-18204064 (-)  GRCh38

Alleles and phenotypes

All alleles(5) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous null mutants show impaired synaptic transmission, insulin secretion and glucose intolerance. This mutation and another chemically induced allele affect circadian period and sleep patterns. Heterozygotes show milder circadian rhythm anomalies.

 

Gene Ontology (GO) classifications

All GO classifications: (44 annotations)

Process	axonogenesis, exocytosis, ...
Component	acrosomal vesicle, axon, ...
Function	ATPase activator activity, ATPase binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)

Data Summary: Results (19)    Tissues (14)    Images (1)
Theiler Stages: 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	13
RNA in situ	3
Western blot	3

cDNA source data(78)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(80) Genomic(2) cDNA(78)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000016949 (Evidence)
Ensembl Gene Model	ENSMUSG00000031840 (Evidence)
Entrez Gene	19339 (Evidence)
UniGene	5083
DFCI	TC1574121, TC1624230
DoTS	DT.110853509, DT.533094, DT.94361216
NIA Mouse Gene Index	U009442
Consensus CDS Project	CCDS22379.1
International Mouse Knockout Project Status	Rab3a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016949	VEGA Gene Model | MGI Sequence Detail	3999	C57BL/6J
transcript	OTTMUST00000041105	VEGA | MGI Sequence Detail	1363	Not Applicable
polypeptide	OTTMUSP00000018415	VEGA | MGI Sequence Detail	220	Not Applicable

All sequences(58) RefSeq(10) UniProt(4)

Polymorphisms

SNPs within 2kb(11 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR001806	Small GTPase superfamily
InterPro	IPR003579	Small GTPase superfamily, Rab type
InterPro	IPR005225	Small GTP-binding protein domain
Protein Ontology	PR:000013617	ras-related protein Rab-3A

References

(Earliest) J:13259 Baumert M, et al., Structure of the murine rab3A gene: correlation of genomic organization with antibody epitopes. Biochem J. 1993 Jul 1;293(Pt 1):157-63
(Latest) J:204165 Feliciano P, et al., Synapsin II and Rab3a cooperate in the regulation of epileptic and synaptic activity in the CA1 region of the hippocampus. J Neurosci. 2013 Nov 13;33(46):18319-30
All references(89)

Other accession IDs

MGD-MRK-13746