Rab3a MGI Mouse Gene Detail - MGI:97843 - RAB3A, member RAS oncogene family

Rab3a Gene Detail

Symbol

Rab3a
Name

RAB3A, member RAS oncogene family

Feature Type

protein coding gene
IDs

MGI:97843
NCBI Gene: 19339
Gene Overview

MyGene.info: RAB3A

Sequence Map

Chr8:70754679-70758677 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

3999 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 34.15 cM
Mapping Data

4 experiments

Human Ortholog

RAB3A, RAB3A, member RAS oncogene family

Vertebrate Orthologs

9

Human Ortholog

RAB3A, RAB3A, member RAS oncogene family
Orthology source: HomoloGene, HGNC
Links

HGNC:9777

NCBI Gene ID: 5864

neXtProt AC: NX_P20336
Chr Location

19p13.2; chr19:18196799-18204064 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 20629
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: RAB3A
Protein SuperFamily

Ras-related protein Rab
Gene Tree

Rab3a

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Phenotype Summary

3 phenotypes from 2 alleles in 5 genetic backgrounds
14 phenotypes from multigenic genotypes
38 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (ENU)

1
Chemically induced (other)

1
Gene trapped

1
Targeted

3
Genomic Mutations

1 involving Rab3a
Incidental Mutations

Mutagenetix , APF

Homozygous null mutants show impaired synaptic transmission, insulin secretion and glucose intolerance. This mutation and another chemically induced allele affect circadian period and sleep patterns. Heterozygotes show milder circadian rhythm anomalies.

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All GO Annotations

53
GO References

20

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

19
Tissues

15
cDNA Data

78
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase rab3a

ZFIN rab3aa

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Rab3a interacts with 73 markers (Mir15a, Mir15b, Mir92-2, ...) View All

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All Sequences

52
RefSeq

8
UniProt

4
CCDS

CCDS22379.1
UniGene

5083

			Length	Strain/Species	Flank
genomic	OTTMUSG00000016949	VEGA Gene Model \| MGI Sequence Detail	3999	C57BL/6J	± kb
transcript	OTTMUST00000053431	VEGA \| MGI Sequence Detail	1442	Not Applicable
polypeptide	OTTMUSP00000025402	VEGA \| MGI Sequence Detail	220	Not Applicable

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SNPs within 2kb

11 from dbSNP Build 142

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UniProt

4 Sequences
Protein Ontology

PR:000013617 ras-related protein Rab-3A
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001806 Small GTPase superfamily

IPR005225 Small GTP-binding protein domain

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All nucleic 80

Genomic 2

cDNA 78

Microarray probesets 5

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MGD-MRK-13746

Summaries

All 92

Developmental Gene Expression 9

Gene Ontology 20

Phenotypes 38
Earliest

J:13259 Baumert M, et al., Structure of the murine rab3A gene: correlation of genomic organization with antibody epitopes. Biochem J. 1993 Jul 1;293(Pt 1):157-63
Latest

J:225179 Sedej S, et al., Rab3a is critical for trapping alpha-MSH granules in the high Ca(2)(+)-affinity pool by preventing constitutive exocytosis. PLoS One. 2013;8(10):e78883

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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