Rab3a MGI Mouse Gene Detail - MGI:97843 - RAB3A, member RAS oncogene family

Symbol

Rab3a
Name

RAB3A, member RAS oncogene family

Feature Type

protein coding gene
IDs

MGI:97843
NCBI Gene: 19339
Gene Overview

MyGene.info: RAB3A
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr8:70754679-70758677 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 34.15 cM
Mapping Data

4 experiments

SNPs within 2kb

11 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97843	protein coding gene	Chr8:70754679-70758686 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033723	protein coding gene	Chr8:71056795-71059619 (+)
A/J	MGP_AJ_G0033706	protein coding gene	Chr8:68160514-68163338 (+)
AKR/J	MGP_AKRJ_G0033631	protein coding gene	Chr8:70115442-70119440 (+)
BALB/cJ	MGP_BALBcJ_G0033702	protein coding gene	Chr8:68396348-68399172 (+)
C3H/HeJ	MGP_C3HHeJ_G0033412	protein coding gene	Chr8:70761226-70764050 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034219	protein coding gene	Chr8:73736213-73739037 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031163	protein coding gene	Chr8:62978242-62981079 (+)
CAST/EiJ	MGP_CASTEiJ_G0032737	protein coding gene	Chr8:70234601-70237418 (+)
CBA/J	MGP_CBAJ_G0033390	protein coding gene	Chr8:76401281-76404105 (+)
DBA/2J	MGP_DBA2J_G0033544	protein coding gene	Chr8:67879277-67882101 (+)
FVB/NJ	MGP_FVBNJ_G0033485	protein coding gene	Chr8:67016554-67019378 (+)
LP/J	MGP_LPJ_G0033631	protein coding gene	Chr8:71077838-71080662 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033528	protein coding gene	Chr8:79029928-79032752 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034237	protein coding gene	Chr8:70294552-70297376 (+)
PWK/PhJ	MGP_PWKPhJ_G0032445	protein coding gene	Chr8:67176645-67179469 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032281	protein coding gene	Chr8:69261052-69264036 (+)
WSB/EiJ	MGP_WSBEiJ_G0032852	protein coding gene	Chr8:70661871-70664682 (+)

Human Ortholog

RAB3A, RAB3A, member RAS oncogene family

Vertebrate Orthologs

9

Human Ortholog

RAB3A, RAB3A, member RAS oncogene family
Orthology source: HomoloGene, HGNC
Links

HGNC:9777

NCBI Gene ID: 5864

neXtProt AC: NX_P20336

UniProt: P20336
Chr Location

19p13.11; chr19:18196799-18204064 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 20629
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: RAB3A
Protein SuperFamily

Ras-related protein Rab
Gene Tree

Rab3a

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Phenotype Summary

2 phenotypes from 2 alleles in 4 genetic backgrounds
14 phenotypes from multigenic genotypes
38 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (ENU)

1
Chemically induced (other)

1
Gene trapped

1
Targeted

3
Genomic Mutations

1 involving Rab3a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

8 strains or lines available

Homozygous null mutants show impaired synaptic transmission, insulin secretion and glucose intolerance. This mutation and another chemically induced allele affect circadian period and sleep patterns. Heterozygotes show milder circadian rhythm anomalies.

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All GO Annotations

84
GO References

23

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

26
Tissues

19
cDNA Data

79
Literature Summary

10

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rab3a

ZFIN rab3aa

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Rab3a interacts with 73 markers (Mir15a, Mir15b, Mir92-2, ...) View All

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All Sequences

60
RefSeq

10
UniProt

4
CCDS

CCDS22379.1
UniGene

5083

Ensembl

ENSMUSG00000031840 (Evidence)
NCBI Gene

19339 (Evidence)

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031840	Ensembl Gene Model \| MGI Sequence Detail	3999	C57BL/6J	± kb
transcript	ENSMUST00000110090	Ensembl \| MGI Sequence Detail	1375	Not Applicable
polypeptide	ENSMUSP00000105717	Ensembl \| MGI Sequence Detail	220	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013617 Ras-related protein Rab-3A

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR037872 Rab3

IPR001806 Small GTPase

IPR005225 Small GTP-binding protein domain

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All nucleic 81

Genomic 2

cDNA 79

Microarray probesets 5

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MGD-MRK-13746

Summaries

All 106

Developmental Gene Expression 10

Gene Ontology 23

Phenotypes 38
Earliest

J:13259 Baumert M, et al., Structure of the murine rab3A gene: correlation of genomic organization with antibody epitopes. Biochem J. 1993 Jul 1;293(Pt 1):157-63
Latest

J:235944 Bello OD, et al., Rab3A, a possible marker of cortical granules, participates in cortical granule exocytosis in mouse eggs. Exp Cell Res. 2016 Sep 10;347(1):42-51

TSS for Rab3a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr77817	Chr8:70754679-70754751 (+)	36 bp
Tssr77818	Chr8:70755880-70755892 (+)	1,207 bp
Tssr77819	Chr8:70755950-70755968 (+)	1,280 bp
Tssr77820	Chr8:70756453-70756473 (+)	1,784 bp
Tssr77821	Chr8:70758087-70758098 (+)	3,414 bp
Tssr77822	Chr8:70758108-70758134 (+)	3,442 bp
Tssr77823	Chr8:70758183-70758200 (+)	3,513 bp
Tssr2601	Chr8:70758256-70758267 (+)	3,583 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 12/03/2019 MGI 6.14