Pygl
Gene Detail

Symbol Name ID

Pygl liver glycogen phosphorylase MGI:97829

Feature Type

protein coding gene

Genetic Map

Chromosome 12

29.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr12:70190811-70231488 bp, - strand From VEGA annotation of GRCm38   40678 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:84371  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: glucan phosphorylase
Gene Tree: Pygl

Human homologs

Human Homolog		PYGL, phosphorylase, glycogen, liver
NCBI Gene ID		5836
neXtProt AC		NX_P06737
Human Synonyms		GSD6
Human Chr (Location)		14q21-q22; chr14:51371935-51411248 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PYGL

Alleles and phenotypes

All alleles(1) : Targeted(1)

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	5-phosphoribose 1-diphosphate biosynthetic process, carbohydrate metabolic process, ...
Component	cytoplasm, plasma membrane
Function	AMP binding, ATP binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (102)    Tissues (97)    Images (8)
Theiler Stages: 11, 13, 22, 28

Assay Type	Results
RNA in situ	96
RT-PCR	6

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000025904 (Evidence)
Ensembl Gene Model	ENSMUSG00000021069 (Evidence)
Entrez Gene	110095 (Evidence)
DFCI	TC1577070, TC1748360
DoTS	DT.530693, DT.91319370, DT.97364909
NIA Mouse Gene Index	U034044
EC	2.4.1.1
Consensus CDS Project	CCDS25957.1
International Mouse Knockout Project Status	Pygl

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025904	VEGA Gene Model | MGI Sequence Detail	40678	C57BL/6J
transcript	OTTMUST00000063841	VEGA | MGI Sequence Detail	2825	Not Applicable
polypeptide	OTTMUSP00000031636	VEGA | MGI Sequence Detail	850	Not Applicable

All sequences(40) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(5) : SNPs(185 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011833	Glycogen/starch/alpha-glucan phosphorylase
InterPro	IPR000811	Glycosyl transferase, family 35
Protein Ontology	PR:000013521	glycogen phosphorylase, liver form

References

(Earliest) J:9387 Aldrich CJ, et al., Regulation of Qa-1 expression and determinant modification by an H-2D-linked gene, Qdm. Immunogenetics. 1988;28(5):334-44
(Latest) J:193325 Boj SF, et al., Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell. 2012 Dec 21;151(7):1595-607
All references(35)

Other accession IDs

MGD-MRK-13702