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Pvalb
Gene Detail
Symbol

Name
ID
Pvalb
parvalbumin
MGI:97821
Synonyms
Parv, PV, Pva
Feature Type
protein coding gene
Genetic Map
Chromosome 15
36.93 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr15:78191114-78206400 bp, - strand
From VEGA annotation of GRCm38

  15287 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2137  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PVALB
Protein SuperFamily: parvalbumin
Gene Tree: Pvalb

Human
homologs
PVALB, parvalbumin
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5816
neXtProt AC: NX_P20472

Human Synonyms: D22S749

Human Chr (Location): 22q13.1; chr22:36800701-36819473 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(2) Radiation induced(1) Targeted(11)
Genomic Mutations involving Pvalb (1)
 
Mice homozygous for deletion of this marker show slower cotraction-relaxation of fast twitch muscle and and increased force generation. Abnormalities are also reported in Purkinje cell morphology.
 
Phenotype Images(2)
Interactions
Pvalb interacts with 67 markers (Mir18, Mir18b, Mir23a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cytosolic calcium ion homeostasis
Component axon, cytoplasm, ...
Function calcium ion binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (236 records)
Data Summary: Results (296)    Tissues (179)    Images (77)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 28
RNA in situ 220
RT-PCR 48
cDNA source data(84)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase pvalb.1, pvalb.2 ; ZFIN pvalb6, pvalb7    NEW 
Molecular
reagents
All nucleic(104) Genomic(13) cDNA(87) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000031047 (Evidence)
Ensembl Gene Model ENSMUSG00000005716 (Evidence)
Entrez Gene 19293 (Evidence)
UniGene 2766
DFCI TC1577974
DoTS DT.101319698, DT.534011, DT.55139693
NIA Mouse Gene Index U036378
Consensus CDS Project CCDS27609.1
International Mouse Phenotyping Consortium Status Pvalb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031047 VEGA Gene Model | MGI Sequence Detail 15287 C57BL/6J ±  kb
transcript OTTMUST00000076988 VEGA | MGI Sequence Detail 977 Not Applicable 
polypeptide OTTMUSP00000040596 VEGA | MGI Sequence Detail 110 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(5) : SNPs within 2kb(146 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR008080 Parvalbumin
Protein Ontology PR:000013502 parvalbumin alpha
References
(Earliest) J:7524 Stuhlfauth I, et al., Calcium-binding protein, parvalbumin, is reduced in mutant mammalian muscle with abnormal contractile properties. Proc Natl Acad Sci U S A. 1984 Aug;81(15):4814-8
(Latest) J:220370 Wohr M, et al., Lack of parvalbumin in mice leads to behavioral deficits relevant to all human autism core symptoms and related neural morphofunctional abnormalities. Transl Psychiatry. 2015;5:e525
All references(400)
Other
accession IDs
MGD-MRK-13692

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory