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Ptprz1 Gene Detail
Summary
  • Symbol
    Ptprz1
  • Name
    protein tyrosine phosphatase, receptor type Z, polypeptide 1
  • Synonyms
    DSD-1-PG, phosphacan, PTPbeta, Ptprz, Ptpz, PTPzeta, Rptpbeta, RPTPz
  • Feature Type
    protein coding gene
  • IDs
    MGI:97816
    NCBI Gene: 19283
  • Gene Overview
    MyGene.info: PTPRZ1
Location & Maps
more
  • Sequence Map
    Chr6:22875502-23052916 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      177415 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 9.92 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PTPRZ1, protein tyrosine phosphatase, receptor type Z1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PTPRZ1, protein tyrosine phosphatase, receptor type Z1
    Orthology source: HomoloGene
  • Synonyms
    HPTPZ, HPTPzeta, phosphacan, PTP18, PTPRZ, PTPZ, PTP-ZETA, RPTPB, RPTPbeta, R-PTP-zeta-2
  • Links
    NCBI Gene ID: 5803
    neXtProt AC: NX_P23471

  • Chr Location
    7q31.3; chr7:121873105-122062036 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PTPRZ1 associations

Human Disease Mouse Models
       Helicobacter Pylori Infection, Susceptibility to   OMIM: 600263
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 3 alleles in 5 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted null mutations demonstrate an impaired ability to recover from inflamatory lesions of the CNS or gastric mucosa. Mice homozygous for a knock-out allele exhibit increased tactile and thermal nociception thresholds.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055926 VEGA Gene Model | MGI Sequence Detail 177415 C57BL/6J ±  kb
transcript OTTMUST00000138353 VEGA | MGI Sequence Detail 8068 Not Applicable  
polypeptide OTTMUSP00000072754 VEGA | MGI Sequence Detail 2312 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1380 from dbSNP Build 142
Protein
Information
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  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000013482 receptor-type tyrosine-protein phosphatase zeta
  • EC
  • InterPro Domains
    IPR001148 Alpha carbonic anhydrase
    IPR003961 Fibronectin type III
    IPR013783 Immunoglobulin-like fold
    IPR016130 Protein-tyrosine phosphatase, active site
    IPR003595 Protein-tyrosine phosphatase, catalytic
    IPR029021 Protein-tyrosine phosphatase-like
    IPR000242 PTP type protein phosphatase
    IPR000387 Tyrosine specific protein phosphatases domain
Molecular
Reagents
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  • All nucleic 196
    Genomic 1
    cDNA 189
    Primer pair 4
    Other 2

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-13685, MGI:2141501
References
more
  • Summaries
    All 73
    Developmental Gene Expression 27
    Gene Ontology 10
    Phenotypes 15
  • Earliest
    J:16798 Krueger NX, et al., A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7417-21
  • Latest
    J:226163 Kuboyama K, et al., Inactivation of Protein Tyrosine Phosphatase Receptor Type Z by Pleiotrophin Promotes Remyelination through Activation of Differentiation of Oligodendrocyte Precursor Cells. J Neurosci. 2015 Sep 2;35(35):12162-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory