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Ptprz1 Gene Detail
Summary
  • Symbol
    Ptprz1
  • Name
    protein tyrosine phosphatase, receptor type Z, polypeptide 1
  • Synonyms
    DSD-1-PG, phosphacan, PTPbeta, Ptprz, Ptpz, PTPzeta, Rptpbeta, RPTPz
  • Feature Type
    protein coding gene
  • IDs
    MGI:97816
    NCBI Gene: 19283
  • Gene Overview
    MyGene.info: PTPRZ1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:22875502-23052916 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 9.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1380 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97816
protein coding gene Chr6:22875315-23052916 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030485
protein coding gene Chr6:20383125-20566861 (+)
A/J MGP_AJ_G0030458
protein coding gene Chr6:19546765-19728319 (+)
AKR/J MGP_AKRJ_G0030385
protein coding gene Chr6:20182129-20374222 (+)
BALB/cJ MGP_BALBcJ_G0030468
protein coding gene Chr6:19639352-19818478 (+)
C3H/HeJ MGP_C3HHeJ_G0030181
protein coding gene Chr6:20148584-20329221 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030922
protein coding gene Chr6:21030632-21220884 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028133
protein coding gene Chr6:18124183-18301018 (+)
CAST/EiJ MGP_CASTEiJ_G0029583
protein coding gene Chr6:20051230-20248132 (+)
CBA/J MGP_CBAJ_G0030159
protein coding gene Chr6:21742526-21944793 (+)
DBA/2J MGP_DBA2J_G0030303
protein coding gene Chr6:19469350-19648994 (+)
FVB/NJ MGP_FVBNJ_G0030257
protein coding gene Chr6:19252365-19433928 (+)
LP/J MGP_LPJ_G0030390
protein coding gene Chr6:20519574-20708084 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030293
protein coding gene Chr6:23582172-23779308 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030952
protein coding gene Chr6:20143254-20330358 (+)
PWK/PhJ MGP_PWKPhJ_G0029297
protein coding gene Chr6:19084595-19270441 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029133
protein coding gene Chr6:19863406-20045118 (+)
WSB/EiJ MGP_WSBEiJ_G0029659
protein coding gene Chr6:20044011-20231199 (+)



Homology
more
  • Human Ortholog
    PTPRZ1, protein tyrosine phosphatase receptor type Z1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PTPRZ1, protein tyrosine phosphatase receptor type Z1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HPTPZ, HPTPzeta, phosphacan, PTP18, PTPRZ, PTPZ, PTP-ZETA, RPTPB, RPTPbeta, R-PTP-zeta-2
  • Links
    NCBI Gene ID: 5803
    neXtProt AC: NX_P23471
    UniProt: P23471

  • Chr Location
    7q31.32; chr7:121873105-122062036 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 3 alleles in 5 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for targeted null mutations demonstrate an impaired ability to recover from inflamatory lesions of the CNS or gastric mucosa. Mice homozygous for a knock-out allele exhibit increased tactile and thermal nociception thresholds.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000068748 Ensembl Gene Model | MGI Sequence Detail 177415 C57BL/6J ±  kb
transcript ENSMUST00000090568 Ensembl | MGI Sequence Detail 8068 Not Applicable  
polypeptide ENSMUSP00000088056 Ensembl | MGI Sequence Detail 2312 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 198
    Genomic 2
    cDNA 188
    Primer pair 6
    Other 2

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-13685, MGI:2141501
References
more
  • Summaries
    All 89
    Developmental Gene Expression 33
    Gene Ontology 15
    Phenotypes 20
  • Earliest
    J:16798 Krueger NX, et al., A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7417-21
  • Latest
    J:273694 Tanga N, et al., The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice. Glia. 2019 May;67(5):967-984

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory