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Ptprz1
Gene Detail
 Symbol
Name
ID
Ptprz1
protein tyrosine phosphatase, receptor type Z, polypeptide 1
MGI:97816
Synonyms DSD-1-PG, phosphacan, PTPbeta, Ptprz, Ptpz, PTPzeta, Rptpbeta, RPTPz
Feature Type protein coding gene
Genetic Map
Chromosome 6
9.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:22875502-23052916 bp, + strand
From NCBI annotation of GRCm38

  177415 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
HomoloGene:2136  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 2 zebrafish

Gene Tree: Ptprz1

Human
homologs
Human Homolog PTPRZ1, protein tyrosine phosphatase, receptor-type, Z polypeptide 1
NCBI Gene ID 5803
neXtProt AC  NX_P23471
Human Synonyms  HPTPZ, HPTPzeta, phosphacan, PTP18, PTPRZ, PTPZ, PTP-ZETA, RPTPB, RPTPbeta, R-PTP-zeta-2
Human Chr (Location)  7q31.3; chr7:121873105-122062036 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PTPRZ1
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for targeted null mutations demonstrate an impaired ability to recover from inflamatory lesions of the CNS or gastric mucosa. Mice homozygous for a knock-out allele exhibit increased tactile and thermal nociception thresholds.
 
Interactions
Ptprz1 interacts with 280 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process axonogenesis, dephosphorylation, ...
Component extracellular region, integral component of membrane, ...
Function hydrolase activity, phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (105)    Tissues (70)    Images (22)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 60
Northern blot 14
Western blot 24
RT-PCR 5
cDNA source data(189)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(196) Genomic(1) cDNA(189) Primer pair(4) Other(2)
Microarray probesets(8)
Other database
links
Ensembl Gene ModelENSMUSG00000068748 (Evidence)
Entrez Gene19283 (Evidence)
UniGene41639
DFCITC1576441, TC1601942, TC1650287, TC1706352, TC1709084, TC1758815
DoTSDT.101310889, DT.101708902, DT.111102774, DT.50315316, DT.524007, DT.91594520, DT.97345058
NIA Mouse Gene IndexU042723, U322517
EC3.1.3.48
Consensus CDS ProjectCCDS39437.1
International Mouse Knockout Project StatusPtprz1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19283 NCBI Gene Model | MGI Sequence Detail 177415 C57BL/6J ±  kb
transcript NM_001081306 RefSeq | MGI Sequence Detail 8068 Not Specified 
polypeptide B9EKR1 UniProt | EBI | MGI Sequence Detail 2312 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(19) UniProt(9)
Polymorphisms SNPs within 2kb(1381 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001148 Alpha carbonic anhydrase
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR003595 Protein-tyrosine phosphatase, catalytic
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology PR:000013482 receptor-type tyrosine-protein phosphatase zeta
Graphical View of Protein Domain Structure
References (Earliest) J:16798 Krueger NX, et al., A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7417-21
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(73)
Other
accession IDs
MGD-MRK-13685, MGI:2141501

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory