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Ptprz1
Gene Detail
Symbol

Name
ID
Ptprz1
protein tyrosine phosphatase, receptor type Z, polypeptide 1
MGI:97816
Synonyms
DSD-1-PG, phosphacan, PTPbeta, Ptprz, Ptpz, PTPzeta, Rptpbeta, RPTPz
Feature Type
protein coding gene
Genetic Map
Chromosome 6
9.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:22875502-23052916 bp, + strand
From Ensembl annotation of GRCm38

  177415 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2136  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 2 zebrafish

HCOP human homology predictions: PTPRZ1
Gene Tree: Ptprz1

Human
homologs
PTPRZ1, protein tyrosine phosphatase, receptor-type, Z polypeptide 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5803
neXtProt AC: NX_P23471

Human Synonyms: HPTPZ, HPTPzeta, phosphacan, PTP18, PTPRZ, PTPZ, PTP-ZETA, RPTPB, RPTPbeta, R-PTP-zeta-2

Human Chr (Location): 7q31.3; chr7:121873105-122062036 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PTPRZ1

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for targeted null mutations demonstrate an impaired ability to recover from inflamatory lesions of the CNS or gastric mucosa. Mice homozygous for a knock-out allele exhibit increased tactile and thermal nociception thresholds.
 
Interactions
Ptprz1 interacts with 279 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process axonal fasciculation, axonogenesis, ...
Component axon, cytoplasm, ...
Function fibroblast growth factor binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (27 records)
Data Summary: Results (105)    Tissues (71)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 60
Northern blot 14
Western blot 24
RT-PCR 5
cDNA source data(189)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA PTPRZ1 ; Xenbase ptprz1 ; ZFIN ca16c, ptprz1b    NEW 
Molecular
reagents
All nucleic(196) Genomic(1) cDNA(189) Primer pair(4) Other(2)
Microarray probesets(8)
Other database
links
Ensembl Gene Model ENSMUSG00000068748 (Evidence)
Entrez Gene 19283 (Evidence)
UniGene 41639
DFCI TC1576441, TC1601942, TC1650287, TC1706352, TC1709084, TC1758815
DoTS DT.101310889, DT.101708902, DT.111102774, DT.50315316, DT.524007, DT.91594520, DT.97345058
NIA Mouse Gene Index U042723, U322517
EC 3.1.3.48
Consensus CDS Project CCDS39437.1
International Mouse Phenotyping Consortium Status Ptprz1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000068748 Ensembl Gene Model | MGI Sequence Detail 177415 C57BL/6J ±  kb
transcript ENSMUST00000090568 Ensembl | MGI Sequence Detail 8068 Not Applicable 
polypeptide ENSMUSP00000088056 Ensembl | MGI Sequence Detail 2312 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(19) UniProt(9)
Polymorphisms
SNPs within 2kb(1381 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001148 Alpha carbonic anhydrase
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR003595 Protein-tyrosine phosphatase, catalytic
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology PR:000013482 receptor-type tyrosine-protein phosphatase zeta
References
(Earliest) J:16798 Krueger NX, et al., A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7417-21
(Latest) J:219223 Nagalakshmi VK, et al., microRNA-dependent temporal gene expression in the ureteric bud epithelium during mammalian kidney development. Dev Dyn. 2015 Mar;244(3):444-56
All references(74)
Other
accession IDs
MGD-MRK-13685, MGI:2141501

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory