Ptprz1
Gene Detail

Symbol Name ID

Ptprz1 protein tyrosine phosphatase, receptor type Z, polypeptide 1 MGI:97816

Synonyms

DSD-1-PG, phosphacan, PTPbeta, Ptprz, Ptpz, PTPzeta, Rptpbeta, RPTPz

Feature Type

protein coding gene

Genetic Map

Chromosome 6

9.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr6:22875502-23052916 bp, + strand From NCBI annotation of GRCm38   177415 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2136  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken

Gene Tree: Ptprz1

Human homologs

Human Homolog		PTPRZ1, protein tyrosine phosphatase, receptor-type, Z polypeptide 1
NCBI Gene ID		5803
neXtProt AC		NX_P23471
Human Synonyms		HPTPZ, HPTPzeta, phosphacan, PTP18, PTPRZ, PTPZ, PTP-ZETA, RPTPB, RPTPbeta, R-PTP-zeta-2
Human Chr (Location)		7q31.3; chr7:121513159-121702090 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PTPRZ1

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for targeted null mutations demonstrate an impaired ability to recover from inflamatory lesions of the CNS or gastric mucosa. Mice homozygous for a knock-out allele exhibit increased tactile and thermal nociception thresholds.

 

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	axonogenesis
Component	perineuronal net, proteinaceous extracellular matrix
Function	hydrolase activity, phosphoprotein phosphatase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (24 records)
Data Summary: Results (105)    Tissues (70)    Images (22)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	60
Northern blot	14
Western blot	24
RT-PCR	5

cDNA source data(191)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(198) Genomic(1) cDNA(191) Primer pair(4) Other(2)
Microarray probesets(8)

Other database links

Ensembl Gene Model	ENSMUSG00000068748 (Evidence)
Entrez Gene	19283 (Evidence)
UniGene	41639
DFCI	TC1576441, TC1601942, TC1650287, TC1706352, TC1709084, TC1758815
DoTS	DT.101310889, DT.101708902, DT.111102774, DT.50315316, DT.524007, DT.91594520, DT.97345058
NIA Mouse Gene Index	U042723, U322517
Consensus CDS Project	CCDS39437.1
International Mouse Knockout Project Status	Ptprz1

Sequences

Length	Strain/Species
genomic	19283	NCBI Gene Model | MGI Sequence Detail	177415	C57BL/6J
transcript	NM_001081306	RefSeq | MGI Sequence Detail	8068	Not Specified
polypeptide	NP_001074775	RefSeq | MGI Sequence Detail	2312	Not Specified

All sequences(60) RefSeq(5) UniProt(9)

Polymorphisms

SNPs(946 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001148	Alpha carbonic anhydrase
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR000387	Protein-tyrosine/Dual specificity phosphatase
InterPro	IPR016130	Protein-tyrosine phosphatase, active site
InterPro	IPR003595	Protein-tyrosine phosphatase, catalytic
InterPro	IPR000242	Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology	PR:000013482	receptor-type tyrosine-protein phosphatase zeta

References

(Earliest) J:16798 Krueger NX, et al., A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7417-21
(Latest) J:192518 Dwyer CA, et al., RPTPzeta/phosphacan is abnormally glycosylated in a model of muscle-eye-brain disease lacking functional POMGnT1. Neuroscience. 2012 Sep 18;220:47-61
All references(66)

Other accession IDs

MGD-MRK-13685, MGI:2141501