About   Help   FAQ
Ptpre
Gene Detail
 Symbol
Name
ID
Ptpre
protein tyrosine phosphatase, receptor type, E
MGI:97813
Synonyms PTPe, PTPepsilon, RPTPepsilon
Feature Type protein coding gene
Genetic Map
Chromosome 7
81.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:135537824-135686294 bp, + strand
From NCBI annotation of GRCm38

  148471 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31387  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: receptor tyrosine-protein phosphatase, alpha/epsilon types
Gene Tree: Ptpre

Human
homologs
Human Homolog PTPRE, protein tyrosine phosphatase, receptor type, E
NCBI Gene ID 5791
neXtProt AC  NX_P23469
Human Synonyms  HPTPE, PTPE, R-PTP-EPSILON
Human Chr (Location)  10q26; chr10:127907061-128085916 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit early-onset peripheral myelination defects, increased activity of voltage-gated potassium channels in Schwann cells, and increased trabecular bone mass due to cell-specific defects in osteoclast function in young females.
 
Interactions
Ptpre interacts with 325 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process dephosphorylation, negative regulation of insulin receptor signaling pathway, ...
Component cytoplasm, integral component of membrane, ...
Function hydrolase activity, phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (20)    Tissues (4)   
Theiler Stages: 21, 23, 26, 28
Assay TypeResults
Immunohistochemistry 4
Western blot 9
RT-PCR 7
cDNA source data(55)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(58) cDNA(56) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000041836 (Evidence)
Entrez Gene19267 (Evidence)
UniGene945
DFCITC1580991, TC1649098
DoTSDT.101201792, DT.101277009, DT.101365498, DT.110983799, DT.522987, DT.94159787
NIA Mouse Gene IndexU008891
EC3.1.3.48
Consensus CDS ProjectCCDS21944.1
International Mouse Knockout Project StatusPtpre
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19267 NCBI Gene Model | MGI Sequence Detail 148471 C57BL/6J ±  kb
transcript NM_011212 RefSeq | MGI Sequence Detail 5411 Not Specified 
polypeptide P49446 UniProt | EBI | MGI Sequence Detail 699 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(12) UniProt(4)
Polymorphisms RFLP(3) : SNPs within 2kb(639 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
InterPro IPR016336 Receptor tyrosine-protein phosphatase, alpha/epsilon-type
Protein Ontology PR:000013468 receptor-type tyrosine-protein phosphatase epsilon
Graphical View of Protein Domain Structure
References (Earliest) J:29004 Yi T, et al., Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification. Blood. 1991 Nov 1;78(9):2222-8
(Latest) J:190252 Ebner-Bennatan S, et al., Multifaceted modulation of K+ channels by protein-tyrosine phosphatase epsilon tunes neuronal excitability. J Biol Chem. 2012 Aug 10;287(33):27614-28
All references(54)
Other
accession IDs
MGD-MRK-13682

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/23/2014
MGI 5.19
The Jackson Laboratory