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Ptpre Gene Detail
Summary
  • Symbol
    Ptpre
  • Name
    protein tyrosine phosphatase, receptor type, E
  • Synonyms
    PTPe, PTPepsilon, RPTPepsilon
  • Feature Type
    protein coding gene
  • IDs
    MGI:97813
    NCBI Gene: 19267
  • Gene Overview
    MyGene.info: PTPRE
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:135537824-135686294 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 81.27 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    639 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97813
protein coding gene Chr7:135537481-135686294 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033135
protein coding gene Chr7:140388720-140548527 (+)
A/J MGP_AJ_G0033117
protein coding gene Chr7:136520842-136617493 (+)
AKR/J MGP_AKRJ_G0033049
protein coding gene Chr7:140189806-140287937 (+)
BALB/cJ MGP_BALBcJ_G0033118
protein coding gene Chr7:136281040-136376414 (+)
C3H/HeJ MGP_C3HHeJ_G0032832
protein coding gene Chr7:140049925-140148338 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033629
protein coding gene Chr7:145704493-145858949 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030602
protein coding gene Chr7:137702181-137852211 (+)
CAST/EiJ MGP_CASTEiJ_G0032162
protein coding gene Chr7:132105767-132266729 (+)
CBA/J MGP_CBAJ_G0032805
protein coding gene Chr7:150659174-150755948 (+)
DBA/2J MGP_DBA2J_G0032957
protein coding gene Chr7:134529891-134625696 (+)
FVB/NJ MGP_FVBNJ_G0032909
protein coding gene Chr7:134280329-134475178 (+)
LP/J MGP_LPJ_G0033051
protein coding gene Chr7:141911112-142082518 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032942
protein coding gene Chr7:151440969-151604676 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033649
protein coding gene Chr7:139210201-139321251 (+)
PWK/PhJ MGP_PWKPhJ_G0031868
protein coding gene Chr7:127548704-127702006 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031714
protein coding gene Chr7:125947174-126102497 (+)
WSB/EiJ MGP_WSBEiJ_G0032273
protein coding gene Chr7:140002659-140170703 (+)



Homology
more
  • Human Ortholog
    PTPRE, protein tyrosine phosphatase receptor type E
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PTPRE, protein tyrosine phosphatase receptor type E
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HPTPE, PTPE, R-PTP-EPSILON
  • Links
    NCBI Gene ID: 5791
    neXtProt AC: NX_P23469
    UniProt: P23469

  • Chr Location
    10q26.2; chr10:127907061-128085855 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit early-onset peripheral myelination defects, increased activity of voltage-gated potassium channels in Schwann cells, and increased trabecular bone mass due to cell-specific defects in osteoclast function in young females.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19267 NCBI Gene Model | MGI Sequence Detail 148471 C57BL/6J ±  kb
    transcript NM_011212 RefSeq | MGI Sequence Detail 5411 Not Specified  
    polypeptide P49446 UniProt | EBI | MGI Sequence Detail 699 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000013468 receptor-type tyrosine-protein phosphatase epsilon
    • EC
    • InterPro Domains
      IPR016130 Protein-tyrosine phosphatase, active site
      IPR003595 Protein-tyrosine phosphatase, catalytic
      IPR029021 Protein-tyrosine phosphatase-like
      IPR000242 PTP type protein phosphatase
      IPR016336 Receptor tyrosine-protein phosphatase, alpha/epsilon-type
      IPR000387 Tyrosine specific protein phosphatases domain
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 57
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13682
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 8
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:29004 Yi T, et al., Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification. Blood. 1991 Nov 1;78(9):2222-8
    • Latest
      J:229091 Branco MR, et al., Maternal DNA Methylation Regulates Early Trophoblast Development. Dev Cell. 2016 Jan 25;36(2):152-63

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    07/16/2019
    MGI 6.14
    The Jackson Laboratory