Ptpre
Gene Detail

Symbol Name ID

Ptpre protein tyrosine phosphatase, receptor type, E MGI:97813

Synonyms

PTPe, PTPepsilon, RPTPepsilon

Feature Type

protein coding gene

Genetic Map

Chromosome 7

81.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr7:135537824-135686294 bp, + strand From NCBI annotation of GRCm38   148471 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31387  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: receptor tyrosine-protein phosphatase, alpha/epsilon types
Gene Tree: Ptpre

Human homologs

Human Homolog		PTPRE, protein tyrosine phosphatase, receptor type, E
NCBI Gene ID		5791
neXtProt AC		NX_P23469
Human Synonyms		HPTPE, PTPE, R-PTP-EPSILON
Human Chr (Location)		10q26; chr10:129705325-129884180 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Mice homozygous for a knock-out allele exhibit early-onset peripheral myelination defects, increased activity of voltage-gated potassium channels in Schwann cells, and increased trabecular bone mass due to cell-specific defects in osteoclast function in young females.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	dephosphorylation, negative regulation of insulin receptor signaling pathway, ...
Component	cytoplasm, integral to membrane, ...
Function	hydrolase activity, phosphatase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (20)    Tissues (4)   
Theiler Stages: 21, 23, 26, 28

Assay Type	Results
Immunohistochemistry	4
Western blot	9
RT-PCR	7

cDNA source data(55)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(58) cDNA(56) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000041836 (Evidence)
Entrez Gene	19267 (Evidence)
UniGene	945
DFCI	TC1580991, TC1649098
DoTS	DT.101201792, DT.101277009, DT.101365498, DT.110983799, DT.522987, DT.94159787
NIA Mouse Gene Index	U008891
EC	3.1.3.48
Consensus CDS Project	CCDS21944.1
International Mouse Knockout Project Status	Ptpre

Sequences

Length	Strain/Species
genomic	19267	NCBI Gene Model | MGI Sequence Detail	148471	C57BL/6J
transcript	NM_011212	RefSeq | MGI Sequence Detail	5411	Not Specified
polypeptide	P49446	UniProt | EBI | MGI Sequence Detail	699	Not Applicable

All sequences(37) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(3) : SNPs(588 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000387	Protein-tyrosine/Dual-specificity phosphatase
InterPro	IPR016130	Protein-tyrosine phosphatase, active site
InterPro	IPR000242	Protein-tyrosine phosphatase, receptor/non-receptor type
InterPro	IPR016336	Receptor tyrosine-protein phosphatase, alpha/epsilon-type
Protein Ontology	PR:000013468	receptor-type tyrosine-protein phosphatase epsilon

Graphical View of Protein Domain Structure

References

(Earliest) J:29004 Yi T, et al., Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification. Blood. 1991 Nov 1;78(9):2222-8
(Latest) J:190252 Ebner-Bennatan S, et al., Multifaceted modulation of K+ channels by protein-tyrosine phosphatase epsilon tunes neuronal excitability. J Biol Chem. 2012 Aug 10;287(33):27614-28
All references(54)

Other accession IDs

MGD-MRK-13682