Ptprcap
Gene Detail

Symbol Name ID

Ptprcap protein tyrosine phosphatase, receptor type, C polypeptide-associated protein MGI:97811

Synonyms

CD-45-AP, LSM-1

Feature Type

protein coding gene

Genetic Map

Chromosome 19

3.86 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr19:4154606-4156751 bp, + strand From VEGA annotation of GRCm38   2146 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:48358  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Protein SuperFamily: receptor tyrosine-protein phosphatase C-associated protein CD45-AP
Gene Tree: Ptprcap

Human homologs

Human Homolog		PTPRCAP, protein tyrosine phosphatase, receptor type, C-associated protein
NCBI Gene ID		5790
neXtProt AC		NX_Q14761
Human Synonyms		CD45-AP, LPAP
Human Chr (Location)		11q13.3; chr11:67435510-67437682 (-)  GRCh38

Alleles and phenotypes

All alleles(9) : Gene trapped(3) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele display impaired T and B cell responses to antigen receptor stimulation. Mice for a second knock-out allele show enlarged lymph nodes and increased lymph node cellularity but not significantly altered polyclonal T-cell responses.

 

Gene Ontology (GO) classifications

All GO classifications: (3 annotations)

Component

integral component of membrane, membrane, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (18)    Tissues (11)    Images (5)
Theiler Stages: 20, 23, 24, 28

Assay Type	Results
RNA in situ	9
Northern blot	9

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) Genomic(2) cDNA(11)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000028312 (Evidence)
Ensembl Gene Model	ENSMUSG00000045826 (Evidence)
Entrez Gene	19265 (Evidence)
DFCI	TC1578498
NIA Mouse Gene Index	U038751
Consensus CDS Project	CCDS37884.1
International Mouse Knockout Project Status	Ptprcap

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028312	VEGA Gene Model | MGI Sequence Detail	2146	C57BL/6J
transcript	OTTMUST00000070174	VEGA | MGI Sequence Detail	927	Not Applicable
polypeptide	OTTMUSP00000035732	VEGA | MGI Sequence Detail	197	Not Applicable

All sequences(26) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs within 2kb(27 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR016553	Receptor tyrosine-protein phosphatase C-associated protein CD45-AP
Protein Ontology	PR:000013466	protein tyrosine phosphatase receptor type C-associated protein

References

(Earliest) J:16674 Takeda A, et al., Molecular cloning of the CD45-associated 30-kDa protein. J Biol Chem. 1994 Jan 28;269(4):2357-60
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(42)

Other accession IDs

MGD-MRK-13680, MGI:2147585