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Ptprcap Gene Detail
Summary
  • Symbol
    Ptprcap
  • Name
    protein tyrosine phosphatase, receptor type, C polypeptide-associated protein
  • Synonyms
    CD-45-AP, LSM-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97811
    NCBI Gene: 19265
  • Gene Overview
    MyGene.info: PTPRCAP
Location & Maps
more
Homology
more
  • Human Ortholog
    PTPRCAP, protein tyrosine phosphatase, receptor type C associated protein
  • Vertebrate Orthologs
    6
  • Human Ortholog
    PTPRCAP, protein tyrosine phosphatase, receptor type C associated protein
    Orthology source: HomoloGene
  • Synonyms
    CD45-AP, LPAP
  • Links
    NCBI Gene ID: 5790
    neXtProt AC: NX_Q14761

  • Chr Location
    11q13.3; chr11:67435510-67437682 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    3
  • Targeted
    7
  • Incidental Mutations
Mice homozygous for a knock-out allele display impaired T and B cell responses to antigen receptor stimulation. Mice for a second knock-out allele show enlarged lymph nodes and increased lymph node cellularity but not significantly altered polyclonal T-cell responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028312 VEGA Gene Model | MGI Sequence Detail 2146 C57BL/6J ±  kb
transcript OTTMUST00000070174 VEGA | MGI Sequence Detail 927 Not Applicable  
polypeptide OTTMUSP00000035732 VEGA | MGI Sequence Detail 197 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    27 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000013466 protein tyrosine phosphatase receptor type C-associated protein
  • InterPro Domains
    IPR016553 Protein tyrosine phosphatase receptor type C-associated protein
Molecular
Reagents
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  • All nucleic 13
    Genomic 2
    cDNA 11

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-13680, MGI:2147585
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:16674 Takeda A, et al., Molecular cloning of the CD45-associated 30-kDa protein. J Biol Chem. 1994 Jan 28;269(4):2357-60
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory