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Ptprcap Gene Detail
Summary
  • Symbol
    Ptprcap
  • Name
    protein tyrosine phosphatase, receptor type, C polypeptide-associated protein
  • Synonyms
    CD-45-AP, LSM-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97811
    NCBI Gene: 19265
  • Gene Overview
    MyGene.info: PTPRCAP
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr19:4204645-4206709 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 3.86 cM, cytoband B
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97811
 protein coding gene Chr19:4203603-4206750 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024651
 protein coding gene Chr19:993595-995740 (+)
A/J MGP_AJ_G0024617
 protein coding gene Chr19:956258-958403 (+)
AKR/J MGP_AKRJ_G0024590
 protein coding gene Chr19:981426-983571 (+)
BALB/cJ MGP_BALBcJ_G0024617
 protein coding gene Chr19:945809-947954 (+)
C3H/HeJ MGP_C3HHeJ_G0024385
 protein coding gene Chr19:976500-978645 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025065
 protein coding gene Chr19:1032449-1034594 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022494
 protein coding gene Chr19:898691-900802 (+)
CAST/EiJ MGP_CASTEiJ_G0023857
 protein coding gene Chr19:987349-989505 (+)
CBA/J MGP_CBAJ_G0024356
 protein coding gene Chr19:1090098-1092243 (+)
DBA/2J MGP_DBA2J_G0024484
 protein coding gene Chr19:916249-918394 (+)
FVB/NJ MGP_FVBNJ_G0024451
 protein coding gene Chr19:926659-928804 (+)
LP/J MGP_LPJ_G0024570
 protein coding gene Chr19:986520-988665 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024481
 protein coding gene Chr19:1036245-1038390 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025112
 protein coding gene Chr19:977892-980037 (+)
PWK/PhJ MGP_PWKPhJ_G0023603
 protein coding gene Chr19:968407-970562 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023408
 protein coding gene Chr19:958433-960585 (+)
WSB/EiJ MGP_WSBEiJ_G0023919
 protein coding gene Chr19:966246-968368 (+)



Homology
more
  • Human Ortholog
    PTPRCAP, protein tyrosine phosphatase receptor type C associated protein
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTPRCAP, protein tyrosine phosphatase receptor type C associated protein
  • Synonyms
    CD45-AP, LPAP
  • Links
    NCBI Gene ID: 5790
    neXtProt AC: NX_Q14761
    UniProt: Q14761

  • Chr Location
    11q13.2; chr11:67435510-67437682 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display impaired T and B cell responses to antigen receptor stimulation. Mice for a second knock-out allele show enlarged lymph nodes and increased lymph node cellularity but not significantly altered polyclonal T-cell responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    4
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    690
  • Tissues
    11
  • cDNA Data
    12
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19265 NCBI Gene Model | MGI Sequence Detail 2065 C57BL/6J ±  kb
    transcript NM_016933 RefSeq | MGI Sequence Detail 853 C57BL/6  
    polypeptide Q64697 UniProt | EBI | MGI Sequence Detail 197 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000013466 protein tyrosine phosphatase receptor type C-associated protein
      (term hierarchy)
    • InterPro Domains
      IPR016553 Protein tyrosine phosphatase receptor type C-associated protein
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 2
      cDNA 12

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13680, MGI:2147585
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:16674 Takeda A, et al., Molecular cloning of the CD45-associated 30-kDa protein. J Biol Chem. 1994 Jan 28;269(4):2357-60
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/19/2021
    MGI 6.17     		The Jackson Laboratory