Ptprcap MGI Mouse Gene Detail - MGI:97811 - protein tyrosine phosphatase, receptor type, C polypeptide-associated protein

Ptprcap Gene Detail

Symbol

Ptprcap
Name

protein tyrosine phosphatase, receptor type, C polypeptide-associated protein
Synonyms

CD-45-AP, LSM-1

Feature Type

protein coding gene
IDs

MGI:97811
NCBI Gene: 19265
Gene Overview

MyGene.info: PTPRCAP

Sequence Map

Chr19:4154606-4156751 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

2146 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 3.86 cM, cytoband B
Mapping Data

12 experiments

Human Ortholog

PTPRCAP, protein tyrosine phosphatase, receptor type C associated protein

Vertebrate Orthologs

6

Human Ortholog

PTPRCAP, protein tyrosine phosphatase, receptor type C associated protein
Orthology source: HomoloGene, HGNC
Synonyms

CD45-AP, LPAP
Links

HGNC:9667

NCBI Gene ID: 5790

neXtProt AC: NX_Q14761

UniProt: Q14761
Chr Location

11q13.2; chr11:67435510-67437682 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 48358
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 macaque, rhesus
HCOP

human homology predictions: PTPRCAP
Protein SuperFamily

receptor tyrosine-protein phosphatase C-associated protein CD45-AP
Gene Tree

Ptprcap

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Phenotype Summary

7 phenotypes from 3 alleles in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Gene trapped

3
Targeted

7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available

Mice homozygous for a knock-out allele display impaired T and B cell responses to antigen receptor stimulation. Mice for a second knock-out allele show enlarged lymph nodes and increased lymph node cellularity but not significantly altered polyclonal T-cell responses.

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All GO Annotations

5
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

18
Tissues

11
cDNA Data

11
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Ptprcap interacts with 53 markers (Mir19a, Mir19b-1, Mir19b-2, ...) View All

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All Sequences

24
RefSeq

2
UniProt

2
CCDS

CCDS37884.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000028312	VEGA Gene Model \| MGI Sequence Detail	2146	C57BL/6J	± kb
transcript	OTTMUST00000070174	VEGA \| MGI Sequence Detail	927	Not Applicable
polypeptide	OTTMUSP00000035732	VEGA \| MGI Sequence Detail	197	Not Applicable

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SNPs within 2kb

27 from dbSNP Build 142

RFLP

1

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UniProt

2 Sequences
Protein Ontology

PR:000013466 protein tyrosine phosphatase receptor type C-associated protein

(term hierarchy)
InterPro Domains

IPR016553 Protein tyrosine phosphatase receptor type C-associated protein

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All nucleic 13

Genomic 2

cDNA 11

Microarray probesets 3

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MGD-MRK-13680, MGI:2147585

Summaries

All 41

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 9
Earliest

J:16674 Takeda A, et al., Molecular cloning of the CD45-associated 30-kDa protein. J Biol Chem. 1994 Jan 28;269(4):2357-60
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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