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Ptprcap
Gene Detail
 Symbol
Name
ID
Ptprcap
protein tyrosine phosphatase, receptor type, C polypeptide-associated protein
MGI:97811
Synonyms CD-45-AP, LSM-1
Feature Type protein coding gene
Genetic Map
Chromosome 19
3.86 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr19:4154606-4156751 bp, + strand
From VEGA annotation of GRCm38

  2146 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48358  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Protein SuperFamily: receptor tyrosine-protein phosphatase C-associated protein CD45-AP
Gene Tree: Ptprcap

Human
homologs
Human Homolog PTPRCAP, protein tyrosine phosphatase, receptor type, C-associated protein
NCBI Gene ID 5790
neXtProt AC  NX_Q14761
Human Synonyms  CD45-AP, LPAP
Human Chr (Location)  11q13.3; chr11:67435510-67437682 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(3) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display impaired T and B cell responses to antigen receptor stimulation. Mice for a second knock-out allele show enlarged lymph nodes and increased lymph node cellularity but not significantly altered polyclonal T-cell responses.
 
Interactions
Ptprcap interacts with 53 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Component integral component of membrane, membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (18)    Tissues (11)    Images (5)
Theiler Stages: 20, 23, 24, 28
Assay TypeResults
RNA in situ 9
Northern blot 9
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) Genomic(2) cDNA(11)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000028312 (Evidence)
Ensembl Gene ModelENSMUSG00000045826 (Evidence)
Entrez Gene19265 (Evidence)
DFCITC1578498
NIA Mouse Gene IndexU038751
Consensus CDS ProjectCCDS37884.1
International Mouse Knockout Project StatusPtprcap
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028312 VEGA Gene Model | MGI Sequence Detail 2146 C57BL/6J ±  kb
transcript OTTMUST00000070174 VEGA | MGI Sequence Detail 927 Not Applicable 
polypeptide OTTMUSP00000035732 VEGA | MGI Sequence Detail 197 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(27 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016553 Receptor tyrosine-protein phosphatase C-associated protein CD45-AP
Protein Ontology PR:000013466 protein tyrosine phosphatase receptor type C-associated protein
References (Earliest) J:16674 Takeda A, et al., Molecular cloning of the CD45-associated 30-kDa protein. J Biol Chem. 1994 Jan 28;269(4):2357-60
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(42)
Other
accession IDs
MGD-MRK-13680, MGI:2147585

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory