Ptprcap MGI Mouse Gene Detail - MGI:97811 - protein tyrosine phosphatase receptor type C polypeptide-associated protein

Symbol

Ptprcap
Name

protein tyrosine phosphatase receptor type C polypeptide-associated protein
Synonyms

CD-45-AP, LSM-1

Feature Type

protein coding gene
IDs

MGI:97811
NCBI Gene: 19265
Alliance

genome feature page

Sequence Map

Chr19:4204645-4206709 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 3.86 cM, cytoband B
Mapping Data

12 experiments

SNPs within 2kb

27 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97811	protein coding gene	Chr19:4203603-4206750 (+)
129S1/SvImJ	ENSMUSG00200050836	protein coding gene	Chr19:964602-967274 (+)
A/J	ENSMUSG00195051789	protein coding gene	Chr19:1355836-1358508 (+)
AKR/J	ENSMUSG00220044237	protein coding gene	Chr19:1128779-1131452 (+)
BALB/cJ	ENSMUSG00180045480	protein coding gene	Chr19:1730589-1733261 (+)
C3H/HeJ	ENSMUSG00175009509	protein coding gene	Chr19:975315-977987 (+)
C57BL/6NJ	ENSMUSG00215040819	protein coding gene	Chr19:1202906-1205578 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022494	protein coding gene	Chr19:898691-900802 (+)
CAST/EiJ	ENSTCUG00005026148	protein coding gene	Chr19:1109863-1112546 (+)
CBA/J	ENSMUSG00210048472	protein coding gene	Chr19:975622-978294 (+)
DBA/2J	ENSMUSG00185040628	protein coding gene	Chr19:1351933-1354605 (+)
FVB/NJ	ENSMUSG00205048960	protein coding gene	Chr19:1353123-1355796 (+)
JF1/MsJ	ENSUMUG00000052726	protein coding gene	Chr19:1337149-1339830 (+)
LP/J	ENSMUSG00230051836	protein coding gene	Chr19:2270768-2273440 (+)
NOD/ShiLtJ	ENSMUSG00190029609	protein coding gene	Chr19:896925-899597 (+)
NZO/HlLtJ	ENSMUSG00225025657	protein coding gene	Chr19:5979613-5982285 (+)
PWK/PhJ	ENSLUMG00010005483	protein coding gene	Chr19:1113858-1116540 (+)
SPRET/EiJ	ENSMSPG00010039306	protein coding gene	Chr19:1094056-1096734 (+)
WSB/EiJ	ENSIUOG00005045823	protein coding gene	Chr19:980993-983642 (+)

Human Ortholog

PTPRCAP, protein tyrosine phosphatase receptor type C associated protein

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTPRCAP, protein tyrosine phosphatase receptor type C associated protein
Synonyms

CD45-AP, LPAP
Links

HGNC:9667

NCBI Gene ID: 5790

UniProt: Q14761
Chr Location

11q13.2; chr11:67435510-67437682 (-) GRCh38

MGI Vertebrate Homology

Ptprcap stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PTPRCAP
Protein SuperFamily

PTPRC-associated_protein
Gene Tree

Ptprcap

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Phenotype Summary

7 phenotypes from 3 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

2
Gene trapped

3
Targeted

7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele display impaired T and B cell responses to antigen receptor stimulation. Mice for a second knock-out allele show enlarged lymph nodes and increased lymph node cellularity but not significantly altered polyclonal T-cell responses.

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All GO Annotations

4
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

615
Tissues

11
cDNA Data

12
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

43
RefSeq

2
UniProt

3
CCDS

CCDS37884.1

Ensembl

ENSMUSG00000045826 (Evidence)
NCBI Gene

19265

			Length	Strain/Species	Flank
genomic	19265	NCBI Gene Model \| MGI Sequence Detail	2065	C57BL/6J	± kb
transcript	NM_016933	RefSeq \| MGI Sequence Detail	853	C57BL/6
polypeptide	Q64697	UniProt \| EBI \| MGI Sequence Detail	197	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013466 protein tyrosine phosphatase receptor type C-associated protein

(term hierarchy)
InterPro Domains

IPR016553 Protein tyrosine phosphatase receptor type C-associated protein

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All nucleic 14

Genomic 2

cDNA 12

Microarray probesets 3

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MGD-MRK-13680, MGI:2147585

Summaries

All 46

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 11
Earliest

J:16674 Takeda A, et al., Molecular cloning of the CD45-associated 30-kDa protein. J Biol Chem. 1994 Jan 28;269(4):2357-60
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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