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Ptprb Gene Detail
Summary
  • Symbol
    Ptprb
  • Name
    protein tyrosine phosphatase, receptor type, B
  • Synonyms
    3230402H02Rik, VE-PTP
  • Feature Type
    protein coding gene
  • IDs
    MGI:97809
    NCBI Gene: 19263
  • Gene Overview
    MyGene.info: PTPRB
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:116275523-116389535 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      114013 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 64.68 cM, cytoband D2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PTPRB, protein tyrosine phosphatase, receptor type B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PTPRB, protein tyrosine phosphatase, receptor type B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HPTPB, HPTP-BETA, PTPB, R-PTP-BETA, VEPTP
  • Links
    NCBI Gene ID: 5787
    neXtProt AC: NX_P23467
    UniProt: P23467

  • Chr Location
    12q15; chr12:70516850-70637440 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2125
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PTPRB
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    3 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality at E10, impaired vascular maintenace and remodeling, heart defects and abnormal yolk sac vasculature.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020154 Ensembl Gene Model | MGI Sequence Detail 114013 C57BL/6J ±  kb
transcript ENSMUST00000218553 Ensembl | MGI Sequence Detail 7016 Not Applicable  
polypeptide ENSMUSP00000151821 Ensembl | MGI Sequence Detail 2285 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1304 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 12
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-13678, MGI:1924822
References
more
  • Summaries
    All 50
    Developmental Gene Expression 6
    Gene Ontology 10
    Phenotypes 15
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:247344 Takahashi K, et al., Expression of receptor-type protein tyrosine phosphatase in developing and adult renal vasculature. PLoS One. 2017;12(5):e0177192

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory