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Ptprb
Gene Detail
 Symbol
Name
ID
Ptprb
protein tyrosine phosphatase, receptor type, B
MGI:97809
Synonyms 3230402H02Rik, VE-PTP
Feature Type protein coding gene
Genetic Map
Chromosome 10
64.68 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:116301374-116389538 bp, + strand
From NCBI annotation of GRCm38

  88165 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2125  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ptprb

Human
homologs
Human Homolog PTPRB, protein tyrosine phosphatase, receptor type, B
NCBI Gene ID 5787
neXtProt AC  NX_P23467
Human Synonyms  HPTPB, HPTP-BETA, PTPB, R-PTP-BETA, VEPTP
Human Chr (Location)  12q15-q21; chr12:70516850-70637440 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit embryonic lethality at E10, impaired vascular maintenace and remodeling, heart defects and abnormal yolk sac vasculature.
 
Phenotype Images(3)
Interactions
Ptprb interacts with 520 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process angiogenesis, dephosphorylation, ...
Component integral component of membrane, membrane, ...
Function hydrolase activity, phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (49)    Tissues (4)    Images (22)
Theiler Stages: 21, 23
Assay TypeResults
RNA in situ 48
RT-PCR 1
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000020154 (Evidence)
Entrez Gene19263 (Evidence)
DFCITC1583888, TC1595767, TC1612695
DoTSDT.103560251, DT.40148911, DT.40182233, DT.55159563, DT.55229525
NIA Mouse Gene IndexU012032, U090934
EC3.1.3.48
Consensus CDS ProjectCCDS36063.1
International Mouse Knockout Project StatusPtprb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19263 NCBI Gene Model | MGI Sequence Detail 88165 C57BL/6J ±  kb
transcript NM_029928 RefSeq | MGI Sequence Detail 11912 C57BL/6 
polypeptide B2RU80 UniProt | EBI | MGI Sequence Detail 1998 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(6)
Polymorphisms SNPs within 2kb(1013 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
InterPro IPR000772 Ricin B lectin domain
Protein Ontology PR:000013465 receptor-type tyrosine-protein phosphatase beta
Graphical View of Protein Domain Structure
References (Earliest) J:14621 Gebbink MF, et al., Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase. FEBS Lett. 1991 Sep 23;290(1-2):123-30
(Latest) J:194542 Ghai R, et al., Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E643-52
All references(42)
Other
accession IDs
MGD-MRK-13678, MGI:1924822

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory