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Ptprb Gene Detail
Summary
  • Symbol
    Ptprb
  • Name
    protein tyrosine phosphatase, receptor type, B
  • Synonyms
    3230402H02Rik, VE-PTP
  • Feature Type
    protein coding gene
  • IDs
    MGI:97809
    NCBI Gene: 19263
  • Gene Overview
    MyGene.info: PTPRB
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:116275523-116389535 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 64.68 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1304 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97809
protein coding gene Chr10:116275513-116389538 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017744
protein coding gene Chr10:119062780-119158258 (+)
A/J MGP_AJ_G0017720
protein coding gene Chr10:114488765-114578770 (+)
AKR/J MGP_AKRJ_G0017682
protein coding gene Chr10:117787275-117895841 (+)
BALB/cJ MGP_BALBcJ_G0017683
protein coding gene Chr10:114887949-114980411 (+)
C3H/HeJ MGP_C3HHeJ_G0017508
protein coding gene Chr10:118031441-118125112 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018140
protein coding gene Chr10:123199441-123301595 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015820
protein coding gene Chr10:109094240-109179492 (+)
CAST/EiJ MGP_CASTEiJ_G0017070
protein coding gene Chr10:118307435-118402088 (+)
CBA/J MGP_CBAJ_G0017477
protein coding gene Chr10:128015882-128120446 (+)
DBA/2J MGP_DBA2J_G0017582
protein coding gene Chr10:113631990-113720081 (+)
FVB/NJ MGP_FVBNJ_G0017577
protein coding gene Chr10:112588106-112675937 (+)
LP/J MGP_LPJ_G0017657
protein coding gene Chr10:119652291-119745870 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017606
protein coding gene Chr10:130929949-131026479 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018178
protein coding gene Chr10:117868185-117962701 (+)
PWK/PhJ MGP_PWKPhJ_G0016852
protein coding gene Chr10:113711608-113802886 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016642
protein coding gene Chr10:116673368-116772153 (+)
WSB/EiJ MGP_WSBEiJ_G0017130
protein coding gene Chr10:118044580-118145338 (+)



Homology
more
  • Human Ortholog
    PTPRB, protein tyrosine phosphatase receptor type B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PTPRB, protein tyrosine phosphatase receptor type B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HPTPB, HPTP-BETA, PTPB, R-PTP-BETA, VEPTP
  • Links
    NCBI Gene ID: 5787
    neXtProt AC: NX_P23467
    UniProt: P23467

  • Chr Location
    12q15; chr12:70516850-70637440 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2125
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PTPRB
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    4 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality at E10, impaired vascular maintenace and remodeling, heart defects and abnormal yolk sac vasculature.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020154 Ensembl Gene Model | MGI Sequence Detail 114013 C57BL/6J ±  kb
    transcript ENSMUST00000218553 Ensembl | MGI Sequence Detail 7016 Not Applicable  
    polypeptide ENSMUSP00000151821 Ensembl | MGI Sequence Detail 2285 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 16
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13678, MGI:1924822
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 7
      Gene Ontology 10
      Phenotypes 18
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:277513 Friedrich EE, et al., Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions. Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12980-12985

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory