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Ptpn5 Gene Detail
Summary
  • Symbol
    Ptpn5
  • Name
    protein tyrosine phosphatase, non-receptor type 5
  • Synonyms
    Step
  • Feature Type
    protein coding gene
  • IDs
    MGI:97807
    NCBI Gene: 19259
  • Gene Overview
    MyGene.info: PTPN5
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:47077795-47133684 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 30.70 cM, cytoband B3-B5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    396 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97807
protein coding gene Chr7:47077795-47133697 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032281
protein coding gene Chr7:47494847-47550744 (-)
A/J MGP_AJ_G0032260
protein coding gene Chr7:46506131-46561977 (-)
AKR/J MGP_AKRJ_G0032196
protein coding gene Chr7:47823315-47881470 (-)
BALB/cJ MGP_BALBcJ_G0032272
protein coding gene Chr7:46513644-46570034 (-)
C3H/HeJ MGP_C3HHeJ_G0031985
protein coding gene Chr7:48298126-48354928 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032762
protein coding gene Chr7:49783752-49843154 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029778
protein coding gene Chr7:49044802-49102371 (-)
CAST/EiJ MGP_CASTEiJ_G0031313
protein coding gene Chr7:39778678-39835839 (-)
CBA/J MGP_CBAJ_G0031950
protein coding gene Chr7:51442923-51500980 (-)
DBA/2J MGP_DBA2J_G0032107
protein coding gene Chr7:46181708-46237673 (-)
FVB/NJ MGP_FVBNJ_G0032061
protein coding gene Chr7:45998320-46054296 (-)
LP/J MGP_LPJ_G0032188
protein coding gene Chr7:48205165-48261743 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032098
protein coding gene Chr7:50057454-50115531 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032779
protein coding gene Chr7:47032615-47089128 (-)
PWK/PhJ MGP_PWKPhJ_G0031038
protein coding gene Chr7:39567367-39624990 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030876
protein coding gene Chr7:35060082-35118631 (-)
WSB/EiJ MGP_WSBEiJ_G0031433
protein coding gene Chr7:47556111-47615611 (-)



Homology
more
  • Human Ortholog
    PTPN5, protein tyrosine phosphatase non-receptor type 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PTPN5, protein tyrosine phosphatase non-receptor type 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PTPSTEP, STEP, STEP61
  • Links
    NCBI Gene ID: 84867
    neXtProt AC: NX_P54829
    UniProt: P54829

  • Chr Location
    11p15.1; chr11:18727928-18792721 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit normal brain development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030854 Ensembl Gene Model | MGI Sequence Detail 55890 C57BL/6J ±  kb
    transcript ENSMUST00000102626 Ensembl | MGI Sequence Detail 3137 Not Applicable  
    polypeptide ENSMUSP00000099686 Ensembl | MGI Sequence Detail 541 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000013460 tyrosine-protein phosphatase non-receptor type 5
    • PDB
    • EC
    • InterPro Domains
      IPR016130 Protein-tyrosine phosphatase, active site
      IPR003595 Protein-tyrosine phosphatase, catalytic
      IPR008356 Protein-tyrosine phosphatase, KIM-containing
      IPR029021 Protein-tyrosine phosphatase-like
      IPR016334 Protein-tyrosine phosphatase, receptor type R/non-receptor type 5
      IPR000242 PTP type protein phosphatase
      IPR000387 Tyrosine specific protein phosphatases domain
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 4
      cDNA 32
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13676
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 23
    • Earliest
      J:16055 Kaneko Y, et al., Identification of protein tyrosine phosphatases expressed in murine male germ cells. Biochem Biophys Res Commun. 1993 Dec 15;197(2):625-31
    • Latest
      J:274289 Won S, et al., The STEP61 interactome reveals subunit-specific AMPA receptor binding and synaptic regulation. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):8028-8037

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    09/05/2019
    MGI 6.14
    The Jackson Laboratory