Pth1r
Gene Detail

Symbol Name ID

Pth1r parathyroid hormone 1 receptor MGI:97801

Synonyms

PPR, PTH1R, PTH/PTHrP receptor, Pthr1, PTH-related peptide receptor

Feature Type

protein coding gene

Genetic Map

Chromosome 9

60.56 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr9:110722088-110743686 bp, - strand From Ensembl annotation of GRCm38   21599 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:267  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Pth1r

Human homologs

Human Homolog		PTH1R, parathyroid hormone 1 receptor
NCBI Gene ID		5745
neXtProt AC		NX_Q03431
Human Synonyms		PFE, PTHR, PTHR1
Human Chr (Location)		3p22-p21.1; chr3:46877746-46903799 (+)  GRCh38
Disease Associations		(4) Diseases Associated with Human PTH1R

Mutations, alleles, and phenotypes

All mutations/alleles(9) : Gene trapped(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous mutant mice die in mid-gestation or shortly after birth depending on genetic background, are small in size, have short limbs, and accelerated differentiation of chondrocytes resulting in accelerated bone mineralization.

 

Interactions

Pth1r interacts with 31 markers (Mir103-1, Mir130a, Mir133a-1, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (48 annotations)

Process	adenylate cyclase-activating G-protein coupled receptor signaling pathway, adenylate cyclase-modulating G-protein coupled receptor signaling pathway, ...
Component	apical plasma membrane, basolateral plasma membrane, ...
Function	G-protein coupled receptor activity, parathyroid hormone receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (105 records)

Data Summary: Results (304)    Tissues (124)    Images (99)
Theiler Stages: 7, 9, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	12
RNA in situ	288
Northern blot	2
RT-PCR	2

cDNA source data(89)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(107) Genomic(5) cDNA(96) Primer pair(2) Other(4)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000032492 (Evidence)
Entrez Gene	19228 (Evidence)
UniGene	3542
DFCI	TC1578843, TC1620752, TC1634783
DoTS	DT.534032, DT.101377615, DT.94278761
NIA Mouse Gene Index	U031370
Consensus CDS Project	CCDS52940.1
International Mouse Knockout Project Status	Pth1r

Sequences

Length	Strain/Species
genomic	ENSMUSG00000032492	Ensembl Gene Model | MGI Sequence Detail	21599	C57BL/6J
transcript	ENSMUST00000006005	Ensembl | MGI Sequence Detail	2252	Not Applicable
polypeptide	ENSMUSP00000006005	Ensembl | MGI Sequence Detail	591	Not Applicable

All sequences(44) RefSeq(14) UniProt(2)

Polymorphisms

RFLP(1) : SNPs within 2kb(55 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR001879	GPCR, family 2, extracellular hormone receptor domain
InterPro	IPR017981	GPCR, family 2-like
InterPro	IPR002170	GPCR, family 2, parathyroid hormone receptor
InterPro	IPR000832	GPCR, family 2, secretin-like
InterPro	IPR017983	GPCR, family 2, secretin-like, conserved site
Protein Ontology	PR:000013430	parathyroid hormone/parathyroid hormone-related peptide receptor

References

(Earliest) J:2075 Seldin MF, et al., Localization of mouse parathyroid hormone-like peptide gene (Pthlh) to distal chromosome 6 using interspecific backcross mice and in situ hybridization. Cytogenet Cell Genet. 1992;60(3-4):252-4
(Latest) J:201789 Saini V, et al., Parathyroid hormone (PTH)/PTH-related peptide type 1 receptor (PPR) signaling in osteocytes regulates anabolic and catabolic skeletal responses to PTH. J Biol Chem. 2013 Jul 12;288(28):20122-34
All references(178)

Other accession IDs

MGD-MRK-13669