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Pth1r
Gene Detail
Symbol

Name
ID
Pth1r
parathyroid hormone 1 receptor
MGI:97801
Synonyms
PPR, PTH1R, PTH/PTHrP receptor, Pthr1, PTH-related peptide receptor
Feature Type
protein coding gene
Genetic Map
Chromosome 9
60.56 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr9:110722088-110743686 bp, - strand
From Ensembl annotation of GRCm38

  21599 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:267  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PTH1R
Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Pth1r

Human
homologs
PTH1R, parathyroid hormone 1 receptor
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5745
neXtProt AC: NX_Q03431

Human Synonyms: PFE, PTHR, PTHR1

Human Chr (Location): 3p22-p21.1; chr3:46877717-46903799 (+)  GRCh38.p2

Disease Associations: (4) Diseases Associated with Human PTH1R

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(1) Targeted(8) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant mice die in mid-gestation or shortly after birth depending on genetic background, are small in size, have short limbs, and accelerated differentiation of chondrocytes resulting in accelerated bone mineralization.
 
Interactions
Pth1r interacts with 31 markers (Mir103-1, Mir130a, Mir133a-1, ...)
Expression
Literature Summary: (112 records)
Data Summary: Results (306)    Tissues (124)    Images (101)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 12
RNA in situ 290
Northern blot 2
RT-PCR 2
cDNA source data(89)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100492020    NEW 
Molecular
reagents
All nucleic(108) Genomic(5) cDNA(96) Primer pair(2) Other(5)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000032492 (Evidence)
Entrez Gene 19228 (Evidence)
UniGene 3542
DFCI TC1578843, TC1620752, TC1634783
DoTS DT.101377615, DT.534032, DT.94278761
NIA Mouse Gene Index U031370
Consensus CDS Project CCDS52940.1
International Mouse Phenotyping Consortium Status Pth1r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032492 Ensembl Gene Model | MGI Sequence Detail 21599 C57BL/6J ±  kb
transcript ENSMUST00000166716 Ensembl | MGI Sequence Detail 2219 Not Applicable 
polypeptide ENSMUSP00000132064 Ensembl | MGI Sequence Detail 591 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(14) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR017981 GPCR, family 2-like
InterPro IPR002170 GPCR, family 2, parathyroid hormone receptor
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
Protein Ontology PR:000013430 parathyroid hormone/parathyroid hormone-related peptide receptor
References
(Earliest) J:2075 Seldin MF, et al., Localization of mouse parathyroid hormone-like peptide gene (Pthlh) to distal chromosome 6 using interspecific backcross mice and in situ hybridization. Cytogenet Cell Genet. 1992;60(3-4):252-4
(Latest) J:219364 Zhou ZQ, et al., Mutant activated FGFR3 impairs endochondral bone growth by preventing SOX9 downregulation in differentiating chondrocytes. Hum Mol Genet. 2015 Mar 15;24(6):1764-73
All references(186)
Other
accession IDs
MGD-MRK-13669

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory