Pth1r
Gene Detail

Symbol

Name
ID

Pth1r
parathyroid hormone 1 receptor
MGI:97801

Synonyms

PPR, PTH1R, PTH/PTHrP receptor, Pthr1, PTH-related peptide receptor

Feature Type

protein coding gene

Genetic Map

Chromosome 9
60.56 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr9:110722088-110743686 bp, - strand From Ensembl annotation of GRCm38   21599 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:267  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Pth1r

Human
homologs

Human Homolog		PTH1R, parathyroid hormone 1 receptor
NCBI Gene ID		5745
neXtProt AC		NX_Q03431
Human Synonyms		PFE, PTHR, PTHR1
Human Chr (Location)		3p22-p21.1; chr3:46877746-46903799 (+)  GRCh38
Disease Associations		(4) Diseases Associated with Human PTH1R

Mutations,
alleles, and
phenotypes

All mutations/alleles(10) : Gene trapped(1) Targeted(8) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous mutant mice die in mid-gestation or shortly after birth depending on genetic background, are small in size, have short limbs, and accelerated differentiation of chondrocytes resulting in accelerated bone mineralization.

 

Interactions

Pth1r interacts with 31 markers (Mir103-1, Mir130a, Mir133a-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (50 annotations)

Process	adenylate cyclase-activating G-protein coupled receptor signaling pathway, adenylate cyclase-modulating G-protein coupled receptor signaling pathway, ...
Component	apical plasma membrane, basolateral plasma membrane, ...
Function	G-protein coupled receptor activity, parathyroid hormone receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (111 records)

Data Summary: Results (308)    Tissues (126)    Images (101)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	12
RNA in situ	292
Northern blot	2
RT-PCR	2

cDNA source data(89)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(108) Genomic(5) cDNA(96) Primer pair(2) Other(5)
Microarray probesets(3)

Other database
links

Ensembl Gene Model	ENSMUSG00000032492 (Evidence)
Entrez Gene	19228 (Evidence)
UniGene	3542
DFCI	TC1578843, TC1620752, TC1634783
DoTS	DT.101377615, DT.534032, DT.94278761
NIA Mouse Gene Index	U031370
Consensus CDS Project	CCDS52940.1
International Mouse Knockout Project Status	Pth1r

Sequences

Length	Strain/Species
genomic	ENSMUSG00000032492	Ensembl Gene Model | MGI Sequence Detail	21599	C57BL/6J
transcript	ENSMUST00000166716	Ensembl | MGI Sequence Detail	2219	Not Applicable
polypeptide	ENSMUSP00000132064	Ensembl | MGI Sequence Detail	591	Not Applicable

All sequences(45) RefSeq(14) UniProt(3)

Polymorphisms

RFLP(1) : SNPs within 2kb(55 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001879	GPCR, family 2, extracellular hormone receptor domain
InterPro	IPR017981	GPCR, family 2-like
InterPro	IPR002170	GPCR, family 2, parathyroid hormone receptor
InterPro	IPR000832	GPCR, family 2, secretin-like
InterPro	IPR017983	GPCR, family 2, secretin-like, conserved site
Protein Ontology	PR:000013430	parathyroid hormone/parathyroid hormone-related peptide receptor

References

(Earliest) J:2075 Seldin MF, et al., Localization of mouse parathyroid hormone-like peptide gene (Pthlh) to distal chromosome 6 using interspecific backcross mice and in situ hybridization. Cytogenet Cell Genet. 1992;60(3-4):252-4
(Latest) J:214984 Gonzalez-Martin MC, et al., Long bone development requires a threshold of Hox function. Dev Biol. 2014 Aug 15;392(2):454-65
All references(185)

Other
accession IDs

MGD-MRK-13669