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Pth1r
Gene Detail
 Symbol
Name
ID
Pth1r
parathyroid hormone 1 receptor
MGI:97801
Synonyms PPR, PTH1R, PTH/PTHrP receptor, Pthr1, PTH-related peptide receptor
Feature Type protein coding gene
Genetic Map
Chromosome 9
60.56 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr9:110722088-110743686 bp, - strand
From Ensembl annotation of GRCm38

  21599 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:267  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Pth1r

Human
homologs
Human Homolog PTH1R, parathyroid hormone 1 receptor
NCBI Gene ID 5745
neXtProt AC  NX_Q03431
Human Synonyms  PFE, PTHR, PTHR1
Human Chr (Location)  3p22-p21.1; chr3:46877746-46903799 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human PTH1R
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice die in mid-gestation or shortly after birth depending on genetic background, are small in size, have short limbs, and accelerated differentiation of chondrocytes resulting in accelerated bone mineralization.
 
Interactions
Pth1r interacts with 31 markers (Mir103-1, Mir130a, Mir133a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process adenylate cyclase-activating G-protein coupled receptor signaling pathway, adenylate cyclase-modulating G-protein coupled receptor signaling pathway, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function G-protein coupled receptor activity, parathyroid hormone receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (105 records)
Data Summary: Results (304)    Tissues (124)    Images (99)
Theiler Stages: 7, 9, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 12
RNA in situ 288
Northern blot 2
RT-PCR 2
cDNA source data(89)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(107) Genomic(5) cDNA(96) Primer pair(2) Other(4)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000032492 (Evidence)
Entrez Gene19228 (Evidence)
UniGene3542
DFCITC1578843, TC1620752, TC1634783
DoTSDT.101377615, DT.534032, DT.94278761
NIA Mouse Gene IndexU031370
Consensus CDS ProjectCCDS52940.1
International Mouse Knockout Project StatusPth1r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032492 Ensembl Gene Model | MGI Sequence Detail 21599 C57BL/6J ±  kb
transcript ENSMUST00000006005 Ensembl | MGI Sequence Detail 2252 Not Applicable 
polypeptide ENSMUSP00000006005 Ensembl | MGI Sequence Detail 591 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(14) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR017981 GPCR, family 2-like
InterPro IPR002170 GPCR, family 2, parathyroid hormone receptor
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
Protein Ontology PR:000013430 parathyroid hormone/parathyroid hormone-related peptide receptor
References (Earliest) J:2075 Seldin MF, et al., Localization of mouse parathyroid hormone-like peptide gene (Pthlh) to distal chromosome 6 using interspecific backcross mice and in situ hybridization. Cytogenet Cell Genet. 1992;60(3-4):252-4
(Latest) J:201789 Saini V, et al., Parathyroid hormone (PTH)/PTH-related peptide type 1 receptor (PPR) signaling in osteocytes regulates anabolic and catabolic skeletal responses to PTH. J Biol Chem. 2013 Jul 12;288(28):20122-34
All references(178)
Other
accession IDs
MGD-MRK-13669

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory