Ptgfr
Gene Detail

Symbol Name ID

Ptgfr prostaglandin F receptor MGI:97796

Synonyms

FP, PGF

Feature Type

protein coding gene

Genetic Map

Chromosome 3

76.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr3:151798918-151837630 bp, - strand From VEGA annotation of GRCm38   38713 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:741  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: G protein-coupled prostanoid receptor
Gene Tree: Ptgfr

Human homologs

Human Homolog		PTGFR, prostaglandin F receptor (FP)
NCBI Gene ID		5737
neXtProt AC		NX_P43088
Human Synonyms		FP
Human Chr (Location)		1p31.1; chr1:78956728-79006386 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Pregnant females homozygous for a targeted null mutation are unable to deliver their offspring due to lack of induction of the oxytocin receptor and fail to show the normal decline of serum progesterone levels preceding parturition.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	G-protein coupled receptor signaling pathway, negative regulation of apoptotic process, ...
Component	cytoplasm, integral to membrane, ...
Function	G-protein coupled receptor activity, prostaglandin F receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (100)    Tissues (36)    Images (25)
Theiler Stages: 17, 21, 23

Assay Type	Results
RNA in situ	100

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(11)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000025720 (Evidence)
Ensembl Gene Model	ENSMUSG00000028036 (Evidence)
Entrez Gene	19220 (Evidence)
DFCI	TC1584982, TC1614592
DoTS	DT.40139867, DT.97363178
NIA Mouse Gene Index	U024762
Consensus CDS Project	CCDS17913.1
International Mouse Knockout Project Status	Ptgfr

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025720	VEGA Gene Model | MGI Sequence Detail	38713	C57BL/6J
transcript	OTTMUST00000063340	VEGA | MGI Sequence Detail	1535	Not Applicable
polypeptide	OTTMUSP00000031305	VEGA | MGI Sequence Detail	366	Not Applicable

All sequences(37) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(337 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
InterPro	IPR001244	Prostaglandin DP receptor
InterPro	IPR000141	Prostaglandin F receptor
InterPro	IPR008365	Prostanoid receptor
Protein Ontology	PR:000001660	prostaglandin F2-alpha receptor

References

(Earliest) J:16440 Sugimoto Y, et al., Cloning and expression of a cDNA for mouse prostaglandin F receptor. J Biol Chem. 1994 Jan 14;269(2):1356-60
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(59)

Other accession IDs

MGD-MRK-13663, MGI:2139843