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Ptger2
Gene Detail
Symbol

Name
ID
Ptger2
prostaglandin E receptor 2 (subtype EP2)
MGI:97794
Synonyms
EP2, EP2 receptor, Ptgerep2
Feature Type
protein coding gene
Genetic Map
Chromosome 14
22.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:44988195-45003820 bp, + strand
From VEGA annotation of GRCm38

  15626 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:739  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: PTGER2
Protein SuperFamily: G protein-coupled prostanoid receptor
Gene Tree: Ptger2

Human
homologs
PTGER2, prostaglandin E receptor 2 (subtype EP2), 53kDa
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5732
neXtProt AC: NX_P43116

Human Synonyms: EP2

Human Chr (Location): 14q22; chr14:52314298-52328606 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PTGER2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for one targeted null mutation exhibit increased blood pressure when fed a high-salt diet. Female mutants for 2 null alleles have small litters due to impaired ovulation.
 
Interactions
Ptger2 interacts with 204 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Expression
Literature Summary: (5 records)
Data Summary: Results (46)    Tissues (45)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 46
cDNA source data(15)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase ptger2 ; ZFIN ptger2a, ptger2b    NEW 
Molecular
reagents
All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000036411 (Evidence)
Ensembl Gene Model ENSMUSG00000037759 (Evidence)
Entrez Gene 19217 (Evidence)
UniGene 4630
DFCI TC1584355
DoTS DT.40185562
NIA Mouse Gene Index U015520
Consensus CDS Project CCDS26972.1
International Mouse Phenotyping Consortium Status Ptger2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036411 VEGA Gene Model | MGI Sequence Detail 15626 C57BL/6J ±  kb
transcript OTTMUST00000093310 VEGA | MGI Sequence Detail 3684 Not Applicable 
polypeptide OTTMUSP00000051734 VEGA | MGI Sequence Detail 362 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(193 from dbSNP Build 137)    SNPs within 2kb including multiple locations(221)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001923 Prostanoid EP2 receptor
InterPro IPR008365 Prostanoid receptor
Protein Ontology PR:000001658 prostaglandin E2 receptor EP2 subtype
References
(Earliest) J:25578 Fuller JL, et al., Effects of retinal degeneration and brain size upon spatial reversal learning in mice. Percept Mot Skills. 1973 Jun;36(3):947-50
(Latest) J:219607 Johansson JU, et al., Prostaglandin signaling suppresses beneficial microglial function in Alzheimer's disease models. J Clin Invest. 2015 Jan;125(1):350-64
All references(154)
Other
accession IDs
MGD-MRK-13661

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory