Ptger1
Gene Detail

Symbol Name ID

Ptger1 prostaglandin E receptor 1 (subtype EP1) MGI:97793

Synonyms

42kDa, EP1, Ptgerep1

Feature Type

protein coding gene

Genetic Map

Chromosome 8

40.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr8:83666833-83672753 bp, + strand From VEGA annotation of GRCm38   5921 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Ptger1 ± 2 cM)

Protein SuperFamily: G protein-coupled prostanoid receptor
Gene Tree: Ptger1

Human ortholog

PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa NCBI Gene ID 5731
Human Synonyms: EP1
Human Chr19:14583278-14586174 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Homozygous null mice may exhibit partial prenatal lethality, pain threshold abnormalities, behavioral disinhibition in response to stress, low blood pressure, defects in type IV hypersensitivity reactions, resistance to chemically induced tumors and impaired response to water deprivation.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	G-protein coupled receptor signaling pathway, response to lipopolysaccharide, ...
Component	integral to membrane, membrane, ...
Function	G-protein coupled receptor activity, prostaglandin E receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (261)    Tissues (86)    Images (19)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	24
In situ reporter (knock in)	61
RT-PCR	176

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(18) Genomic(3) cDNA(13) Primer pair(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000025957 (Evidence)
Ensembl Gene Model	ENSMUSG00000019464 (Evidence)
Entrez Gene	19216 (Evidence)
Consensus CDS Project	CCDS22458.1
International Mouse Knockout Project Status	Ptger1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025957	VEGA Gene Model | MGI Sequence Detail	5921	C57BL/6J
transcript	OTTMUST00000064025	VEGA | MGI Sequence Detail	4509	Not Applicable
polypeptide	OTTMUSP00000031749	VEGA | MGI Sequence Detail	405	Not Applicable

All sequences(27) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(62 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR001244	Prostaglandin DP receptor
InterPro	IPR000708	Prostanoid EP1 receptor
InterPro	IPR008365	Prostanoid receptor
Protein Ontology	PR:000001657	prostaglandin E2 receptor EP1 subtype

References

(Earliest) J:14684 Watabe A, et al., Cloning and expression of cDNA for a mouse EP1 subtype of prostaglandin E receptor. J Biol Chem. 1993 Sep 25;268(27):20175-8
(Latest) J:188185 Zhen G, et al., PGE2 EP1 receptor exacerbated neurotoxicity in a mouse model of cerebral ischemia and Alzheimer's disease. Neurobiol Aging. 2012 Sep;33(9):2215-9
All references(91)

Other accession IDs

MGD-MRK-13660