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Ptger1
Gene Detail
Symbol

Name
ID
Ptger1
prostaglandin E receptor 1 (subtype EP1)
MGI:97793
Synonyms
42kDa, EP1, Ptgerep1
Feature Type
protein coding gene
Genetic Map
Chromosome 8
40.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:83666833-83672753 bp, + strand
From VEGA annotation of GRCm38

  5921 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:738  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

HCOP human homology predictions: PTGER1
Protein SuperFamily: G protein-coupled prostanoid receptor
Gene Tree: Ptger1

Human
homologs
PTGER1, prostaglandin E receptor 1 (subtype EP1), 42kDa
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5731
neXtProt AC: NX_P34995

Human Synonyms: EP1

Human Chr (Location): 19p13.1; chr19:14472466-14475362 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice may exhibit partial prenatal lethality, pain threshold abnormalities, behavioral disinhibition in response to stress, low blood pressure, defects in type IV hypersensitivity reactions, resistance to chemically induced tumors and impaired response to water deprivation.
 
Interactions
Ptger1 interacts with 267 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (261)    Tissues (86)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
In situ reporter (knock in) 61
RT-PCR 176
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ptger1 ; ZFIN ptger1a, ptger1b    NEW 
Molecular
reagents
All nucleic(18) Genomic(3) cDNA(13) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000025957 (Evidence)
Ensembl Gene Model ENSMUSG00000019464 (Evidence)
Entrez Gene 19216 (Evidence)
Consensus CDS Project CCDS22458.1
International Mouse Phenotyping Consortium Status Ptger1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025957 VEGA Gene Model | MGI Sequence Detail 5921 C57BL/6J ±  kb
transcript OTTMUST00000064025 VEGA | MGI Sequence Detail 4509 Not Applicable 
polypeptide OTTMUSP00000031749 VEGA | MGI Sequence Detail 405 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(106 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001244 Prostaglandin DP receptor
InterPro IPR000708 Prostanoid EP1 receptor
InterPro IPR008365 Prostanoid receptor
Protein Ontology PR:000001657 prostaglandin E2 receptor EP1 subtype
References
(Earliest) J:14684 Watabe A, et al., Cloning and expression of cDNA for a mouse EP1 subtype of prostaglandin E receptor. J Biol Chem. 1993 Sep 25;268(27):20175-8
(Latest) J:219009 Kovarova M, et al., PGE(2) promotes apoptosis induced by cytokine deprivation through EP3 receptor and induces Bim in mouse mast cells. PLoS One. 2014;9(7):e102948
All references(98)
Other
accession IDs
MGD-MRK-13660

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory