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Ptger1 Gene Detail
Summary
  • Symbol
    Ptger1
  • Name
    prostaglandin E receptor 1 (subtype EP1)
  • Synonyms
    42kDa, EP1, Ptgerep1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97793
    NCBI Gene: 19216
  • Gene Overview
    MyGene.info: PTGER1
Location & Maps
more
  • Sequence Map
    Chr8:83666833-83672753 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5921 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 40.22 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    PTGER1, prostaglandin E receptor 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PTGER1, prostaglandin E receptor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EP1
  • Links
    NCBI Gene ID: 5731
    neXtProt AC: NX_P34995

  • Chr Location
    19p13.1; chr19:14472466-14475362 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 5 alleles in 8 genetic backgrounds
    93 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    8
  • Genomic Mutations
    2 involving Ptger1
  • Incidental Mutations
Homozygous null mice may exhibit partial prenatal lethality, pain threshold abnormalities, behavioral disinhibition in response to stress, low blood pressure, defects in type IV hypersensitivity reactions, resistance to chemically induced tumors and impaired response to water deprivation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025957 VEGA Gene Model | MGI Sequence Detail 5921 C57BL/6J ±  kb
transcript OTTMUST00000064025 VEGA | MGI Sequence Detail 4509 Not Applicable  
polypeptide OTTMUSP00000031749 VEGA | MGI Sequence Detail 405 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    97 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001657 prostaglandin E2 receptor EP1 subtype
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR001244 Prostaglandin DP receptor
    IPR000708 Prostanoid EP1 receptor
    IPR008365 Prostanoid receptor
Molecular
Reagents
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  • All nucleic 18
    Genomic 3
    cDNA 13
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-13660
References
more
  • Summaries
    All 104
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 93
  • Earliest
    J:229737 Idell S, et al., Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome. J Clin Invest. 1989 Aug;84(2):695-705
  • Latest
    J:225715 Nasrallah R, et al., Prostaglandin E2 increases proximal tubule fluid reabsorption, and modulates cultured proximal tubule cell responses via EP1 and EP4 receptors. Lab Invest. 2015 Sep;95(9):1044-55

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory