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Prps2 Gene Detail
Summary
  • Symbol
    Prps2
  • Name
    phosphoribosyl pyrophosphate synthetase 2
  • Synonyms
    2610101M19Rik, MGC:28388, Prps-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97776
    NCBI Gene: 110639
Location & Maps
more
  • Sequence Map
    ChrX:167346322-167382749 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      36428 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 78.32 cM, cytoband F2-F3
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    PRPS2, phosphoribosyl pyrophosphate synthetase 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PRPS2, phosphoribosyl pyrophosphate synthetase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PRSII
  • Links
    NCBI Gene ID: 5634
    neXtProt AC: NX_P11908

  • Chr Location
    Xp22.2; chrX:12791355-12824227 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Targeted
    4
Males hemizygous for a null allele show altered B cell physiology with a minor decrease in rates of purine nucleotide biosynthesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019570 VEGA Gene Model | MGI Sequence Detail 36428 C57BL/6J ±  kb
transcript OTTMUST00000046735 VEGA | MGI Sequence Detail 3699 Not Applicable  
polypeptide OTTMUSP00000021121 VEGA | MGI Sequence Detail 318 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    97 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 47
    cDNA 47

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-13630, MGD-MRK-13632, MGI:1915547, MGI:2147833, MGI:2147895
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 3
  • Earliest
    J:9641 Taira M, et al., Tissue-differential expression of two distinct genes for phosphoribosyl pyrophosphate synthetase and existence of the testis-specific transcript. Biochim Biophys Acta. 1989 Mar 1;1007(2):203-8
  • Latest
    J:214383 Cunningham JT, et al., Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer. Cell. 2014 May 22;157(5):1088-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory