Prph
Gene Detail

Symbol Name ID

Prph peripherin MGI:97774

STS

D15Mit42

Synonyms

Prph1

Feature Type

protein coding gene

Genetic Map

Chromosome 15

55.72 cM, cytoband E-F
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr15:99055174-99058978 bp, + strand From NCBI annotation of GRCm38   3805 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4559  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Prph

Human homologs

Human Homolog		PRPH, peripherin
NCBI Gene ID		5630
neXtProt AC		NX_P41219
Human Synonyms		NEF4, PRPH1
Human Chr (Location)		12q12-q13; chr12:49688909-49692481 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PRPH

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Homozygous null mice showed no overt phenotype up to 14 months of age. While overall structure, number, and caliber of large myelinated axons was normal, mice had reduced numbers of a small subset of unmelinated sensory axons.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	intermediate filament cytoskeleton organization
Component	axon, C-fiber, ...
Function	protein binding, structural molecule activity

External Resources: FuncBase

Expression

Literature Summary: (117 records)
Data Summary: Results (89)    Tissues (38)    Images (33)
Theiler Stages: 18, 19, 20, 21, 22, 23, 26, 28

Assay Type	Results
Immunohistochemistry	49
RNA in situ	9
RT-PCR	31

cDNA source data(16)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(22) Genomic(1) cDNA(17) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000023484 (Evidence)
Entrez Gene	19132 (Evidence)
UniGene	2477
DFCI	TC1581067, TC1598946
DoTS	DT.101366171, DT.484718
NIA Mouse Gene Index	U041299
Consensus CDS Project	CCDS27813.1, CCDS49727.1
International Mouse Knockout Project Status	Prph

Sequences

Length	Strain/Species
genomic	19132	NCBI Gene Model | MGI Sequence Detail	3805	C57BL/6J
transcript	NM_013639	RefSeq | MGI Sequence Detail	1865	C57BL/6
polypeptide	P15331	UniProt | EBI | MGI Sequence Detail	475	Not Applicable

All sequences(26) RefSeq(6) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(14 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016044	Filament
InterPro	IPR006821	Intermediate filament head, DNA-binding domain
InterPro	IPR001664	Intermediate filament protein
InterPro	IPR018039	Intermediate filament protein, conserved site
InterPro	IPR002957	Keratin, type I
Protein Ontology	PR:000013289	peripherin

Graphical View of Protein Domain Structure

References

(Earliest) J:32380 Landon F, et al., Multiple mRNAs encode peripherin, a neuronal intermediate filament protein. EMBO J. 1989 Jun;8(6):1719-26
(Latest) J:194894 Couesnon A, et al., CLIPR-59: a protein essential for neuromuscular junction stability during mouse late embryonic development. Development. 2013 Apr;140(7):1583-93
All references(162)

Other accession IDs

MGD-MRK-13628