About   Help   FAQ
Prph
Gene Detail
 Symbol
Name
ID
Prph
peripherin
MGI:97774
STS D15Mit42
Synonyms Prph1
Feature Type protein coding gene
Genetic Map
Chromosome 15
55.72 cM, cytoband E-F
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr15:99055174-99058978 bp, + strand
From NCBI annotation of GRCm38

  3805 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4559  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Prph

Human
homologs
Human Homolog PRPH, peripherin
NCBI Gene ID 5630
neXtProt AC  NX_P41219
Human Synonyms  NEF4, PRPH1
Human Chr (Location)  12q12-q13; chr12:49295013-49298698 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PRPH
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Radiation induced(1) Targeted(1)
Genomic Mutations involving Prph (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice showed no overt phenotype up to 14 months of age. While overall structure, number, and caliber of large myelinated axons was normal, mice had reduced numbers of a small subset of unmelinated sensory axons.
 
Interactions
Prph interacts with 27 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process intermediate filament cytoskeleton organization
Component axon, C-fiber, ...
Function protein binding, structural molecule activity
External Resources: FuncBase
Expression
Literature Summary: (126 records)
Data Summary: Results (90)    Tissues (39)    Images (33)
Theiler Stages: 17, 18, 19, 20, 21, 22, 23, 26, 28
Assay TypeResults
Immunohistochemistry 50
RNA in situ 9
RT-PCR 31
cDNA source data(16)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(17) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000023484 (Evidence)
Entrez Gene19132 (Evidence)
UniGene2477
DFCITC1581067, TC1598946
DoTSDT.101366171, DT.484718
NIA Mouse Gene IndexU041299
Consensus CDS ProjectCCDS27813.1, CCDS49727.1
International Mouse Knockout Project StatusPrph
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19132 NCBI Gene Model | MGI Sequence Detail 3805 C57BL/6J ±  kb
transcript NM_013639 RefSeq | MGI Sequence Detail 1865 C57BL/6 
polypeptide P15331 UniProt | EBI | MGI Sequence Detail 475 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(10) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006821 Intermediate filament head, DNA-binding domain
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR002957 Keratin, type I
Protein Ontology PR:000013289 peripherin
Graphical View of Protein Domain Structure
References (Earliest) J:32380 Landon F, et al., Multiple mRNAs encode peripherin, a neuronal intermediate filament protein. EMBO J. 1989 Jun;8(6):1719-26
(Latest) J:205590 Hancock ML, et al., MicroRNA-132 is enriched in developing axons, locally regulates Rasa1 mRNA, and promotes axon extension. J Neurosci. 2014 Jan 1;34(1):66-78
All references(172)
Other
accession IDs
MGD-MRK-13628

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/23/2014
MGI 5.19
The Jackson Laboratory