About   Help   FAQ
Prph
Gene Detail
Symbol

Name
ID
Prph
peripherin
MGI:97774
STS
Synonyms
Prph1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
55.72 cM, cytoband E-F
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr15:99055174-99058978 bp, + strand
From Ensembl annotation of GRCm38

  3805 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4559  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRPH
Gene Tree: Prph

Human
homologs
PRPH, peripherin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5630
neXtProt AC: NX_P41219

Human Synonyms: NEF4, PRPH1

Human Chr (Location): 12q12-q13; chr12:49295013-49298698 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PRPH

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Radiation induced(1) Targeted(1)
Genomic Mutations involving Prph (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice showed no overt phenotype up to 14 months of age. While overall structure, number, and caliber of large myelinated axons was normal, mice had reduced numbers of a small subset of unmelinated sensory axons.
 
Phenotype Images(2)
Interactions
Prph interacts with 27 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process intermediate filament cytoskeleton organization
Component axon, C-fiber, ...
Function protein binding, protein heterodimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (130 records)
Data Summary: Results (96)    Tissues (43)    Images (37)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 50
RNA in situ 15
RT-PCR 31
cDNA source data(16)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase prph ; ZFIN prph    NEW 
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(17) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000023484 (Evidence)
Entrez Gene 19132 (Evidence)
UniGene 2477
DFCI TC1581067, TC1598946
DoTS DT.101366171, DT.484718
NIA Mouse Gene Index U041299
Consensus CDS Project CCDS27813.1, CCDS49727.1
International Mouse Phenotyping Consortium Status Prph
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023484 Ensembl Gene Model | MGI Sequence Detail 3805 C57BL/6J ±  kb
transcript ENSMUST00000047104 Ensembl | MGI Sequence Detail 1865 Not Applicable 
polypeptide ENSMUSP00000049303 Ensembl | MGI Sequence Detail 507 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(10) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006821 Intermediate filament head, DNA-binding domain
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR002957 Keratin, type I
Protein Ontology PR:000013289 peripherin
References
(Earliest) J:32380 Landon F, et al., Multiple mRNAs encode peripherin, a neuronal intermediate filament protein. EMBO J. 1989 Jun;8(6):1719-26
(Latest) J:211575 Murthy M, et al., Transcription factor Runx1 inhibits proliferation and promotes developmental maturation in a selected population of inner olfactory nerve layer olfactory ensheathing cells. Gene. 2014 May 1;540(2):191-200
All references(173)
Other
accession IDs
MGD-MRK-13628

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/28/2015
MGI 5.22
The Jackson Laboratory