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Prodh
Gene Detail
 Symbol
Name
ID
Prodh
proline dehydrogenase
MGI:97770
Synonyms Pro1, Pro-1, Ym24d07
Feature Type protein coding gene
Genetic Map
Chromosome 16
11.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr16:18060357-18090203 bp, - strand
From VEGA annotation of GRCm38

  29847 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40764  Vertebrate Homology Class
2 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Prodh

Human
homologs
Human Homolog LOC102724788, proline dehydrogenase 1, mitochondrial-like
NCBI Gene ID 102724788
Human Chr (Location)  22
Human Homolog PRODH, proline dehydrogenase (oxidase) 1
NCBI Gene ID 5625
neXtProt AC  NX_O43272
Human Synonyms  HSPOX2, PIG6, POX, PRODH1, PRODH2, TP53I6
Human Chr (Location)  22q11.21; chr22:18912774-18936553 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human PRODH
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(4) Spontaneous(1) Targeted(7)
Genomic Mutations involving Prodh (4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a spontaneous null mutation exhibit a slight reduction in male body weight, hyperprolinemia, increased startle reflex, and regionally altered brain levels of proline, glutamate, gamma-aminobutyric acid, and aspartate.
 
Human Diseases Modeled Using Mouse Prodh (1)    Alleles Annotated to Human Diseases(3)   
Interactions
Prodh interacts with 129 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process oxidation-reduction process, proline catabolic process, ...
Component mitochondrial inner membrane, mitochondrion
Function amino acid binding, FAD binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (192)    Tissues (143)    Images (17)
Theiler Stages: 16, 17, 19, 20, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 137
Northern blot 23
RT-PCR 32
cDNA source data(63)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(79) Genomic(14) cDNA(63) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000028177 (Evidence)
Ensembl Gene ModelENSMUSG00000003526 (Evidence)
Entrez Gene19125 (Evidence)
UniGene28456
DFCITC1578266, TC1593894
NIA Mouse Gene IndexU036854, U190054
EC1.5.5.2
Consensus CDS ProjectCCDS37278.1
International Mouse Knockout Project StatusProdh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028177 VEGA Gene Model | MGI Sequence Detail 29847 C57BL/6J ±  kb
transcript OTTMUST00000069797 VEGA | MGI Sequence Detail 2385 Not Applicable 
polypeptide OTTMUSP00000035500 VEGA | MGI Sequence Detail 599 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(16) UniProt(6)
Polymorphisms SNPs within 2kb(98 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002872 Proline dehydrogenase
InterPro IPR015659 Proline oxidase
Protein Ontology PR:000013263 proline dehydrogenase, mitochondrial
References (Earliest) J:25420 Blake RL, et al., Hyperprolinemia and prolinuria in a new inbred strain of mice, PRO-Re. Science. 1972 May 19;176(36):809-11
(Latest) J:191130 Maynard TM, et al., 22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development. Hum Mol Genet. 2013 Jan 15;22(2):300-12
All references(56)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-13623, MGD-MRK-13624, MGI:1927902

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory