Prodh
Gene Detail

Symbol Name ID

Prodh proline dehydrogenase MGI:97770

Synonyms

Pro1, Pro-1, Ym24d07

Feature Type

protein coding gene

Genetic Map

Chromosome 16

11.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr16:18060357-18090203 bp, - strand From VEGA annotation of GRCm38   29847 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:40764  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Prodh

Human homologs

Human Homolog		PRODH, proline dehydrogenase (oxidase) 1
NCBI Gene ID		5625
neXtProt AC		NX_O43272
Human Synonyms		HSPOX2, PIG6, POX, PRODH1, PRODH2, TP53I6
Human Chr (Location)		22q11.21; chr22:18900287-18924066 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human PRODH

Alleles and phenotypes

All alleles(7) : Targeted(2) Gene trapped(4) Spontaneous(1)
 

Homozygotes for a spontaneous null mutation exhibit a slight reduction in male body weight, hyperprolinemia, increased startle reflex, and regionally altered brain levels of proline, glutamate, gamma-aminobutyric acid, and aspartate.

 
Human Diseases Modeled Using Mouse Prodh (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	glutamate biosynthetic process, oxidation-reduction process, ...
Component	mitochondrial inner membrane, mitochondrion
Function	amino acid binding, FAD binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (192)    Tissues (143)    Images (17)
Theiler Stages: 16, 17, 19, 20, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	137
Northern blot	23
RT-PCR	32

cDNA source data(63)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(79) Genomic(14) cDNA(63) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000028177 (Evidence)
Ensembl Gene Model	ENSMUSG00000003526 (Evidence)
Entrez Gene	19125 (Evidence)
UniGene	28456
DFCI	TC1578266, TC1593894
DoTS	DT.533137, DT.94251814
NIA Mouse Gene Index	U036854, U190054
EC	1.5.99.8
Consensus CDS Project	CCDS37278.1
International Mouse Knockout Project Status	Prodh

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028177	VEGA Gene Model | MGI Sequence Detail	29847	C57BL/6J
transcript	OTTMUST00000069797	VEGA | MGI Sequence Detail	2385	Not Applicable
polypeptide	OTTMUSP00000035500	VEGA | MGI Sequence Detail	599	Not Applicable

All sequences(56) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(86 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002872	Proline dehydrogenase
InterPro	IPR015659	Proline oxidase
Protein Ontology	PR:000013263	proline dehydrogenase, mitochondrial

References

(Earliest) J:25420 Blake RL, et al., Hyperprolinemia and prolinuria in a new inbred strain of mice, PRO-Re. Science. 1972 May 19;176(36):809-11
(Latest) J:191130 Maynard TM, et al., 22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development. Hum Mol Genet. 2013 Jan 15;22(2):300-12
All references(56)

Other accession IDs

MGD-MRK-13623, MGD-MRK-13624, MGI:1927902