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Prodh Gene Detail
Summary
  • Symbol
    Prodh
  • Name
    proline dehydrogenase
  • Synonyms
    Pro1, Pro-1, Ym24d07
  • Feature Type
    protein coding gene
  • IDs
    MGI:97770
    NCBI Gene: 19125
  • Gene Overview
    MyGene.info: PRODH
Location & Maps
more
  • Sequence Map
    Chr16:18060357-18090203 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29847 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 11.19 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    LOC102724788, proline dehydrogenase 1, mitochondrial
  • Vertebrate Orthologs
    11
  • Human Ortholog
    LOC102724788, proline dehydrogenase 1, mitochondrial
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 102724788

  • Chr Location
    22

  • Human Ortholog
    PRODH, proline dehydrogenase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HSPOX2, PIG6, POX, PRODH1, PRODH2, TP53I6
  • Links
    NCBI Gene ID: 5625
    neXtProt AC: NX_O43272

  • Chr Location
    22q11.21; chr22:18912695-18936553 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Prodh mouse models; 2 with human PRODH associations

Human Disease Mouse Models
       Hyperprolinemia, Type I; HYRPRO1   OMIM: 239500 View 1 model
       Schizophrenia 4; SCZD4   OMIM: 600850
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    13 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Gene trapped
    4
  • Spontaneous
    1
  • Targeted
    12
  • Genomic Mutations
    9 involving Prodh
  • Incidental Mutations
Homozygotes for a spontaneous null mutation exhibit a slight reduction in male body weight, hyperprolinemia, increased startle reflex, and regionally altered brain levels of proline, glutamate, gamma-aminobutyric acid, and aspartate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028177 VEGA Gene Model | MGI Sequence Detail 29847 C57BL/6J ±  kb
transcript OTTMUST00000069797 VEGA | MGI Sequence Detail 2385 Not Applicable  
polypeptide OTTMUSP00000035500 VEGA | MGI Sequence Detail 599 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    98 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 79
    Genomic 14
    cDNA 63
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-13623, MGD-MRK-13624, MGI:1927902
References
more
  • Summaries
    All 57
    Developmental Gene Expression 10
    Diseases 13
    Gene Ontology 8
    Phenotypes 51
  • Earliest
    J:25420 Blake RL, et al., Hyperprolinemia and prolinuria in a new inbred strain of mice, PRO-Re. Science. 1972 May 19;176(36):809-11
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory