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Prodh Gene Detail
Summary
  • Symbol
    Prodh
  • Name
    proline dehydrogenase
  • Synonyms
    Pro1, Pro-1, Ym24d07
  • Feature Type
    protein coding gene
  • IDs
    MGI:97770
    NCBI Gene: 19125
  • Gene Overview
    MyGene.info: PRODH
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:18071726-18089283 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 11.19 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    89 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97770
protein coding gene Chr16:18060357-18090203 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022601
protein coding gene Chr16:15255128-15288706 (-)
A/J MGP_AJ_G0022562
protein coding gene Chr16:14500749-14529428 (-)
AKR/J MGP_AKRJ_G0022539
protein coding gene Chr16:15066434-15097871 (-)
BALB/cJ MGP_BALBcJ_G0022567
protein coding gene Chr16:14649621-14679683 (-)
C3H/HeJ MGP_C3HHeJ_G0022334
protein coding gene Chr16:15233451-15265732 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023016
protein coding gene Chr16:15515367-15550028 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020536
protein coding gene Chr16:14556643-14585166 (-)
CAST/EiJ MGP_CASTEiJ_G0021861
protein coding gene Chr16:15119991-15151779 (-)
CBA/J MGP_CBAJ_G0022303
protein coding gene Chr16:16191099-16221362 (-)
DBA/2J MGP_DBA2J_G0022435
protein coding gene Chr16:14411234-14442323 (-)
FVB/NJ MGP_FVBNJ_G0022410
protein coding gene Chr16:14457778-14487640 (-)
LP/J MGP_LPJ_G0022502
protein coding gene Chr16:15043402-15073791 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022432
protein coding gene Chr16:15864415-15898361 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023027
protein coding gene Chr16:15001736-15031891 (-)
PWK/PhJ MGP_PWKPhJ_G0021603
protein coding gene Chr16:14677062-14706644 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021431
protein coding gene Chr16:14966803-14997595 (-)
WSB/EiJ MGP_WSBEiJ_G0021907
protein coding gene Chr16:14988561-15020366 (-)



Homology
more
  • Human Ortholog
    LOC102724788, proline dehydrogenase 1, mitochondrial
  • Vertebrate Orthologs
    11
  • Human Ortholog
    LOC102724788, proline dehydrogenase 1, mitochondrial
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 102724788

  • Chr Location
    22

  • Human Ortholog
    PRODH, proline dehydrogenase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSPOX2, PIG6, POX, PRODH1, PRODH2, TP53I6
  • Links
    NCBI Gene ID: 5625
    neXtProt AC: NX_O43272
    UniProt: O43272

  • Chr Location
    22q11.21; chr22:18912774-18936553 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human PRODH associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous null mutation exhibit a slight reduction in male body weight, hyperprolinemia, increased startle reflex, and regionally altered brain levels of proline, glutamate, gamma-aminobutyric acid, and aspartate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19125 NCBI Gene Model | MGI Sequence Detail 17558 C57BL/6J ±  kb
    transcript NM_011172 RefSeq | MGI Sequence Detail 2283 C57BL/6  
    polypeptide Q9WU79 UniProt | EBI | MGI Sequence Detail 599 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 81
      Genomic 14
      cDNA 65
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13623, MGD-MRK-13624, MGI:1927902
    References
    more
    • Summaries
      All 120
      Developmental Gene Expression 12
      Diseases 5
      Gene Ontology 9
      Phenotypes 77
    • Earliest
      J:25420 Blake RL, et al., Hyperprolinemia and prolinuria in a new inbred strain of mice, PRO-Re. Science. 1972 May 19;176(36):809-11
    • Latest
      J:279573 Fernandez A, et al., Mitochondrial Dysfunction Leads to Cortical Under-Connectivity and Cognitive Impairment. Neuron. 2019 Jun 19;102(6):1127-1142.e3

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    12/03/2019
    MGI 6.14
    The Jackson Laboratory