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Prlr Gene Detail
Summary
  • Symbol
    Prlr
  • Name
    prolactin receptor
  • Synonyms
    Pr-1, Prlr-rs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97763
    NCBI Gene: 19116
  • Alliance
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:10177238-10349180 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 5.23 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    697 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97763
protein coding gene Chr15:10177238-10349180 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021718
protein coding gene Chr15:7292566-7474729 (+)
A/J MGP_AJ_G0021678
protein coding gene Chr15:7121867-7292749 (+)
AKR/J MGP_AKRJ_G0021656
protein coding gene Chr15:7279762-7453704 (+)
BALB/cJ MGP_BALBcJ_G0021685
protein coding gene Chr15:7024654-7200386 (+)
C3H/HeJ MGP_C3HHeJ_G0021461
protein coding gene Chr15:7217428-7398751 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022124
protein coding gene Chr15:7574335-7764721 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019661
protein coding gene Chr15:6595629-6767842 (+)
CAST/EiJ MGP_CASTEiJ_G0020977
protein coding gene Chr15:7273799-7462136 (+)
CBA/J MGP_CBAJ_G0021430
protein coding gene Chr15:7728367-7919328 (+)
DBA/2J MGP_DBA2J_G0021554
protein coding gene Chr15:6977449-7150032 (+)
FVB/NJ MGP_FVBNJ_G0021532
protein coding gene Chr15:6844830-7016809 (+)
LP/J MGP_LPJ_G0021622
protein coding gene Chr15:7200454-7378965 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021557
protein coding gene Chr15:8045978-8232241 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022147
protein coding gene Chr15:7244453-7414681 (+)
PWK/PhJ MGP_PWKPhJ_G0020720
protein coding gene Chr15:7133641-7315719 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020558
protein coding gene Chr15:7191910-7380379 (+)
WSB/EiJ MGP_WSBEiJ_G0021033
protein coding gene Chr15:7247779-7428930 (+)



Homology
more
  • Human Ortholog
    PRLR, prolactin receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRLR, prolactin receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HPRL, hPRLrI, MFAB, RI-PRLR
  • Links
    NCBI Gene ID: 5618
    neXtProt AC: NX_P16471
    UniProt: P16471

  • Chr Location
    5p13.2; chr5:35048295-35230589 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 733
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PRLR
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Prlr mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    55 phenotypes from 1 allele in 7 genetic backgrounds
    18 phenotypes from multigenic genotypes
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal growth, hormone and glucose homeostasis, hair cycling, female reproductive behavior, morphology, and function, and thyroid, prostate, Hardarian, and lacrimal gland morphologies. Heterozygous mice exhibit defective neuron proliferation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19116 NCBI Gene Model | MGI Sequence Detail 171943 C57BL/6J ±  kb
    transcript NM_011169 RefSeq | MGI Sequence Detail 10328 C57BL/6  
    polypeptide Q08501 UniProt | EBI | MGI Sequence Detail 608 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      Genomic 1
      cDNA 42
      Primer pair 11
      Other 1

      Microarray probesets 15
    Other
    Accession IDs
    less
    MGD-MRK-13598, MGD-MRK-13599, MGD-MRK-13614, MGD-MRK-13615, MGI:2146103, MGI:97764
    References
    more
    • Summaries
      All 148
      Developmental Gene Expression 19
      Diseases 1
      Gene Ontology 14
      Phenotypes 69
    • Earliest
      J:7060 Herington AC, et al., Hepatic binding of human and bovine growth hormones and ovine prolactin in the dwarf little mouse. Endocrinology. 1983 Jun;112(6):2032-8
    • Latest
      J:262933 Moreno-Carranza B, et al., Prolactin regulates liver growth during postnatal development in mice. Am J Physiol Regul Integr Comp Physiol. 2018 Jun 1;314(6):R902-R908

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    04/09/2019
    MGI 6.13
    The Jackson Laboratory