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Gene Detail
prolactin receptor
Synonyms Pr-1, Prlr-rs1
Feature Type protein coding gene
Genetic Map
Chromosome 15
5.23 cM
Detailed Genetic Map ± 1 cM

Mapping data(9)
Sequence Map
Chr15:10177238-10349180 bp, + strand
From VEGA annotation of GRCm38

  171943 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:733  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Prlr

Human Homolog PRLR, prolactin receptor
NCBI Gene ID 5618
neXtProt AC  NX_P16471
Human Synonyms  HPRL, hPRLrI, MFAB
Human Chr (Location)  5p13.2; chr5:35048756-35230721 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PRLR
alleles, and
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for a knock-out allele exhibit abnormal growth, hormone and glucose homeostasis, hair cycling, female reproductive behavior, morphology, and function, and thyroid, prostate, Hardarian, and lacrimal gland morphologies. Heterozygous mice exhibit defective neuron proliferation.
Human Diseases Modeled Using Mouse Prlr (1)    Alleles Annotated to Human Diseases(1)   
Prlr interacts with 541 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (27 annotations)
Process activation of transmembrane receptor protein tyrosine kinase activity, JAK-STAT cascade, ...
Component cell surface, integral component of membrane, ...
Function cytokine receptor activity, metal ion binding, ...
External Resources: FuncBase
Literature Summary: (16 records)
Data Summary: Results (294)    Tissues (113)    Images (40)
Theiler Stages: 1, 2, 17, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 178
RT-PCR 116
cDNA source data(36)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(53) Genomic(1) cDNA(40) Primer pair(11) Other(1)
Microarray probesets(15)
Other database
VEGA Gene ModelOTTMUSG00000023932 (Evidence)
Ensembl Gene ModelENSMUSG00000005268 (Evidence)
Entrez Gene19116 (Evidence)
DFCITC1579298, TC1583364, TC1593168, TC1597980, TC1600257, TC1623406, TC1645495, TC1650196, TC1651015
DoTSDT.101241186, DT.40147920, DT.87031856, DT.87072490, DT.87072491, DT.91288463, DT.94312351, DT.94312357
NIA Mouse Gene IndexU016074
Consensus CDS ProjectCCDS27377.1, CCDS56975.1, CCDS56976.1
International Mouse Knockout Project StatusPrlr
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023932 VEGA Gene Model | MGI Sequence Detail 171943 C57BL/6J ±  kb
transcript OTTMUST00000059750 VEGA | MGI Sequence Detail 9900 Not Applicable 
polypeptide OTTMUSP00000029088 VEGA | MGI Sequence Detail 608 Not Applicable 

For the selected sequences
All sequences(129) RefSeq(21) UniProt(12)
Polymorphisms RFLP(1) : SNPs within 2kb(699 from dbSNP Build 137)
InterPro IPR003961 Fibronectin, type III
InterPro IPR015152 Growth hormone/erythropoietin receptor, ligand binding
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003528 Long hematopoietin receptor, single chain, conserved site
Protein Ontology PR:000013248 prolactin receptor
References (Earliest) J:7060 Herington AC, et al., Hepatic binding of human and bovine growth hormones and ovine prolactin in the dwarf little mouse. Endocrinology. 1983 Jun;112(6):2032-8
(Latest) J:206956 Arnold E, et al., The hormone prolactin is a novel, endogenous trophic factor able to regulate reactive glia and to limit retinal degeneration. J Neurosci. 2014 Jan 29;34(5):1868-78
All references(130)
Disease annotation references (1)
accession IDs
MGD-MRK-13598, MGD-MRK-13599, MGD-MRK-13614, MGD-MRK-13615, MGI:2146103, MGI:97764

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory