Prlr
Gene Detail

Symbol Name ID

Prlr prolactin receptor MGI:97763

Synonyms

Pr-1, Pr-3, Prlr-rs1

Feature Type

protein coding gene

Genetic Map

Chromosome 15

5.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr15:10177238-10349180 bp, + strand From VEGA annotation of GRCm38   171943 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:733  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Prlr

Human homologs

Human Homolog		PRLR, prolactin receptor
NCBI Gene ID		5618
neXtProt AC		NX_P16471
Human Synonyms		hPRLrI
Human Chr (Location)		5p13.2; chr5:35048861-35230823 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a knock-out allele exhibit abnormal growth, hormone and glucose homeostasis, hair cycling, female reproductive behavior, morphology, and function, and thyroid, prostate, Hardarian, and lacrimal gland morphologies. Heterozygous mice exhibit defective neuron proliferation.

 
Human Diseases Modeled Using Mouse Prlr (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	activation of transmembrane receptor protein tyrosine kinase activity, cytokine-mediated signaling pathway, ...
Component	cell surface, integral to membrane, ...
Function	cytokine receptor activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (294)    Tissues (103)    Images (40)
Theiler Stages: 1, 2, 17, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	178
RT-PCR	116

cDNA source data(36)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(53) Genomic(1) cDNA(40) Primer pair(11) Other(1)
Microarray probesets(15)

Other database links

VEGA Gene Model	OTTMUSG00000023932 (Evidence)
Ensembl Gene Model	ENSMUSG00000005268 (Evidence)
Entrez Gene	19116 (Evidence)
DFCI	TC1579298, TC1583364, TC1593168, TC1597980, TC1600257, TC1623406, TC1645495, TC1650196, TC1651015
DoTS	DT.101241186, DT.40147920, DT.87031856, DT.87072490, DT.87072491, DT.91288463, DT.94312351, DT.94312357
NIA Mouse Gene Index	U016074
Consensus CDS Project	CCDS27377.1, CCDS56975.1, CCDS56976.1
International Mouse Knockout Project Status	Prlr

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023932	VEGA Gene Model | MGI Sequence Detail	171943	C57BL/6J
transcript	OTTMUST00000059750	VEGA | MGI Sequence Detail	9900	Not Applicable
polypeptide	OTTMUSP00000029088	VEGA | MGI Sequence Detail	608	Not Applicable

All sequences(122) RefSeq(9) UniProt(13)

Polymorphisms

RFLP(1) : SNPs(552 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR015152	Growth hormone/erythropoietin receptor, ligand binding
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003528	Long hematopoietin receptor, single chain, conserved site
Protein Ontology	PR:000013248	prolactin receptor

References

(Earliest) J:7060 Herington AC, et al., Hepatic binding of human and bovine growth hormones and ovine prolactin in the dwarf little mouse. Endocrinology. 1983 Jun;112(6):2032-8
(Latest) J:190524 Shalom-Barak T, et al., Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
All references(119)

Other accession IDs

MGD-MRK-13598, MGD-MRK-13599, MGD-MRK-13614, MGD-MRK-13615, MGI:2146103, MGI:97764