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Prl Gene Detail
Summary
  • Symbol
    Prl
  • Name
    prolactin
  • Synonyms
    Prl1a1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97762
    NCBI Gene: 19109
  • Gene Overview
    MyGene.info: PRL
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:27057570-27065204 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 12.25 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    21 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97762
protein coding gene Chr13:27057570-27065205 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020390
protein coding gene Chr13:24655189-24663564 (+)
A/J MGP_AJ_G0020339
protein coding gene Chr13:24133519-24140935 (+)
AKR/J MGP_AKRJ_G0020319
protein coding gene Chr13:24425116-24432796 (+)
BALB/cJ MGP_BALBcJ_G0020337
protein coding gene Chr13:24113290-24120651 (+)
C3H/HeJ MGP_C3HHeJ_G0020141
protein coding gene Chr13:24496554-24504306 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020774
protein coding gene Chr13:25506605-25514193 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018362
protein coding gene Chr13:22755437-22763086 (+)
CAST/EiJ MGP_CASTEiJ_G0019658
protein coding gene Chr13:24225120-24232587 (+)
CBA/J MGP_CBAJ_G0020095
protein coding gene Chr13:26512854-26524339 (+)
DBA/2J MGP_DBA2J_G0020221
protein coding gene Chr13:23663513-23670899 (+)
FVB/NJ MGP_FVBNJ_G0020205
protein coding gene Chr13:23261955-23269541 (+)
LP/J MGP_LPJ_G0020294
protein coding gene Chr13:24905750-24913144 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020232
protein coding gene Chr13:26835878-26846539 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020816
protein coding gene Chr13:24299471-24307322 (+)
PWK/PhJ MGP_PWKPhJ_G0019412
protein coding gene Chr13:23624387-23632223 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019228
protein coding gene Chr13:23179933-23187722 (+)
WSB/EiJ MGP_WSBEiJ_G0019718
protein coding gene Chr13:24471506-24480573 (+)



Homology
more
  • Human Ortholog
    PRL, prolactin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRL, prolactin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GHA1
  • Links
    NCBI Gene ID: 5617
    neXtProt AC: NX_P01236
    UniProt: P01236

  • Chr Location
    6p22.3; chr6:22287244-22302897 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null female mice have irregular oestrus cycles and are infertile. Defects of the pituitary gland include hyperplasia, which progresses to adenoma, and impaired secretion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19109 NCBI Gene Model | MGI Sequence Detail 7635 C57BL/6J ±  kb
    transcript NM_011164 RefSeq | MGI Sequence Detail 895 C57BL/6  
    polypeptide P06879 UniProt | EBI | MGI Sequence Detail 226 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR009079 Four-helical cytokine-like, core
      IPR018116 Somatotropin hormone, conserved site
      IPR001400 Somatotropin/prolactin
    Molecular
    Reagents
    less
    • All nucleic 1370
      Genomic 1
      cDNA 1364
      Primer pair 4
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13613, MGI:2145398
    References
    more
    • Summaries
      All 201
      Developmental Gene Expression 62
      Gene Ontology 13
      Phenotypes 47
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:264143 Cheung L, et al., NOTCH activity differentially affects alternative cell fate acquisition and maintenance. Elife. 2018 Mar 26;7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory