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Prl Gene Detail
Summary
  • Symbol
    Prl
  • Name
    prolactin
  • Synonyms
    Prl1a1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97762
    NCBI Gene: 19109
  • Gene Overview
    MyGene.info: PRL
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:27057577-27065191 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7615 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 12.25 cM
  • Mapping Data
    13 experiments
Homology
more
  • Human Ortholog
    PRL, prolactin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRL, prolactin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GHA1
  • Links
    NCBI Gene ID: 5617
    neXtProt AC: NX_P01236
    UniProt: P01236

  • Chr Location
    6p22.3; chr6:22287244-22302897 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null female mice have irregular oestrus cycles and are infertile. Defects of the pituitary gland include hyperplasia, which progresses to adenoma, and impaired secretion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000000731 VEGA Gene Model | MGI Sequence Detail 7615 C57BL/6J ±  kb
    transcript OTTMUST00000001375 VEGA | MGI Sequence Detail 872 Not Applicable  
    polypeptide OTTMUSP00000000651 VEGA | MGI Sequence Detail 225 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      21 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR009079 Four-helical cytokine-like, core
      IPR018116 Somatotropin hormone, conserved site
      IPR001400 Somatotropin/prolactin
    Molecular
    Reagents
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    • All nucleic 1369
      Genomic 1
      cDNA 1363
      Primer pair 4
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
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    MGD-MRK-13613, MGI:2145398
    References
    more
    • Summaries
      All 195
      Developmental Gene Expression 59
      Gene Ontology 10
      Phenotypes 47
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:260722 Shea MP, et al., Antiestrogen Therapy Increases Plasticity and Cancer Stemness of Prolactin-Induced ERalpha(+) Mammary Carcinomas. Cancer Res. 2018 Apr 1;78(7):1672-1684

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory