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Prkar1b
Gene Detail
Symbol

Name
ID
Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
MGI:97759
Synonyms
RIbeta
Feature Type
protein coding gene
Genetic Map
Chromosome 5
77.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:139017306-139150001 bp, - strand
From VEGA annotation of GRCm38

  132696 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37665  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRKAR1B
Protein SuperFamily: cAMP-dependent protein kinase, regulatory subunit
Gene Tree: Prkar1b

Human
homologs
PRKAR1B, protein kinase, cAMP-dependent, regulatory, type I, beta
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5575
neXtProt AC: NX_P31321

Human Synonyms: PRKAR1

Human Chr (Location): 7p22; chr7:549196-727676 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(2) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have reduced LTD and LTP in specific CNS tracts, but normal neuroanatomy and behavior. Response to pain after inflammation is reduced, concurrent with decreased plasma extravasation during the inflammatory response.
 
Interactions
Prkar1b interacts with 147 markers (Mir17, Mir18b, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cell proliferation, learning or memory, ...
Component cAMP-dependent protein kinase complex, cytoplasm, ...
Function cAMP binding, cAMP-dependent protein kinase inhibitor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (406)    Tissues (189)    Images (49)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 360
RT-PCR 46
cDNA source data(69)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase prkar1b    NEW 
Molecular
reagents
All nucleic(81) Genomic(10) cDNA(69) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000025121 (Evidence)
Ensembl Gene Model ENSMUSG00000025855 (Evidence)
Entrez Gene 19085 (Evidence)
UniGene 306163
DFCI TC1572687
DoTS DT.101355722, DT.110662204, DT.111080807, DT.488133
NIA Mouse Gene Index U026874
EC 2.7.1.37
Consensus CDS Project CCDS19803.1
International Mouse Phenotyping Consortium Status Prkar1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025121 VEGA Gene Model | MGI Sequence Detail 132696 C57BL/6J ±  kb
transcript OTTMUST00000061796 VEGA | MGI Sequence Detail 2637 Not Applicable 
polypeptide OTTMUSP00000030390 VEGA | MGI Sequence Detail 381 Not Applicable 

For the selected sequences
All sequences(95) RefSeq(10) UniProt(13)
Polymorphisms
RFLP(1) : SNPs within 2kb(588 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002373 cAMP/cGMP-dependent protein kinase
InterPro IPR012198 cAMP-dependent protein kinase regulatory subunit
InterPro IPR003117 cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta
InterPro IPR018488 Cyclic nucleotide-binding, conserved site
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000013229 cAMP-dependent protein kinase type I-beta regulatory subunit
References
(Earliest) J:39500 Clegg CH, et al., Genetic characterization of a brain-specific form of the type I regulatory subunit of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1988 Jun;85(11):3703-7
(Latest) J:188520 Ilouz R, et al., Localization and quaternary structure of the PKA RIbeta holoenzyme. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12443-8
All references(51)
Other
accession IDs
MGD-MRK-13610, MGI:2140854

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory