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Prkar1b Gene Detail
Summary
  • Symbol
    Prkar1b
  • Name
    protein kinase, cAMP dependent regulatory, type I beta
  • Synonyms
    RIbeta
  • Feature Type
    protein coding gene
  • IDs
    MGI:97759
    NCBI Gene: 19085
  • Gene Overview
    MyGene.info: PRKAR1B
Location & Maps
more
  • Sequence Map
    Chr5:139017306-139150001 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      132696 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PRKAR1B, protein kinase cAMP-dependent type I regulatory subunit beta
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PRKAR1B, protein kinase cAMP-dependent type I regulatory subunit beta
    Orthology source: HomoloGene
  • Synonyms
    PRKAR1
  • Links
    NCBI Gene ID: 5575
    neXtProt AC: NX_P31321

  • Chr Location
    7p22; chr7:549196-727676 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Gene trapped
    2
  • Targeted
    1
  • Incidental Mutations
Homozygous null mice have reduced LTD and LTP in specific CNS tracts, but normal neuroanatomy and behavior. Response to pain after inflammation is reduced, concurrent with decreased plasma extravasation during the inflammatory response.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025121 VEGA Gene Model | MGI Sequence Detail 132696 C57BL/6J ±  kb
transcript OTTMUST00000061796 VEGA | MGI Sequence Detail 2637 Not Applicable  
polypeptide OTTMUSP00000030390 VEGA | MGI Sequence Detail 381 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    580 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    13 Sequences
  • Protein Ontology
    PR:000013229 cAMP-dependent protein kinase type I-beta regulatory subunit
  • EC
  • InterPro Domains
    IPR012198 cAMP-dependent protein kinase regulatory subunit
    IPR003117 cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
    IPR018488 Cyclic nucleotide-binding, conserved site
    IPR000595 Cyclic nucleotide-binding domain
    IPR018490 Cyclic nucleotide-binding-like
    IPR014710 RmlC-like jelly roll fold
Molecular
Reagents
less
  • All nucleic 81
    Genomic 10
    cDNA 69
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-13610, MGI:2140854
References
more
  • Summaries
    All 49
    Developmental Gene Expression 8
    Gene Ontology 9
    Phenotypes 8
  • Earliest
    J:39500 Clegg CH, et al., Genetic characterization of a brain-specific form of the type I regulatory subunit of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1988 Jun;85(11):3703-7
  • Latest
    J:228307 Zhou T, et al., Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15666-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory