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Ppic Gene Detail
Summary
  • Symbol
    Ppic
  • Name
    peptidylprolyl isomerase C
  • Synonyms
    cyclophilin C, CyP-20c
  • Feature Type
    protein coding gene
  • IDs
    MGI:97751
    NCBI Gene: 19038
  • Gene Overview
    MyGene.info: PPIC
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:53406341-53418007 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 29.03 cM, cytoband D1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    104 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97751
protein coding gene Chr18:53406332-53418115 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024435
protein coding gene Chr18:52584738-52597459 (-)
A/J MGP_AJ_G0024401
protein coding gene Chr18:50546879-50558580 (-)
AKR/J MGP_AKRJ_G0024371
protein coding gene Chr18:51957894-51969552 (-)
BALB/cJ MGP_BALBcJ_G0024401
protein coding gene Chr18:50732513-50745630 (-)
C3H/HeJ MGP_C3HHeJ_G0024168
protein coding gene Chr18:52102069-52115383 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024847
protein coding gene Chr18:54340066-54352722 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022279
protein coding gene Chr18:50323316-50334983 (-)
CAST/EiJ MGP_CASTEiJ_G0023642
protein coding gene Chr18:52075536-52087167 (-)
CBA/J MGP_CBAJ_G0024138
protein coding gene Chr18:55944372-55958255 (-)
DBA/2J MGP_DBA2J_G0024268
protein coding gene Chr18:50251938-50263834 (-)
FVB/NJ MGP_FVBNJ_G0024235
protein coding gene Chr18:49679226-49690855 (-)
LP/J MGP_LPJ_G0024353
protein coding gene Chr18:52604890-52616610 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024265
protein coding gene Chr18:57679743-57694162 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024894
protein coding gene Chr18:51990246-52003703 (-)
PWK/PhJ MGP_PWKPhJ_G0023386
protein coding gene Chr18:50267484-50279515 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023192
protein coding gene Chr18:52164109-52175621 (-)
WSB/EiJ MGP_WSBEiJ_G0023705
protein coding gene Chr18:51907992-51924792 (-)



Homology
more
  • Human Ortholog
    PPIC, peptidylprolyl isomerase C
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPIC, peptidylprolyl isomerase C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CYPC
  • Links
    NCBI Gene ID: 5480
    neXtProt AC: NX_P45877
    UniProt: P45877

  • Chr Location
    5q23.2; chr5:123023383-123036730 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 19038 NCBI Gene Model | MGI Sequence Detail 11667 C57BL/6J ±  kb
transcript NM_008908 RefSeq | MGI Sequence Detail 1286 C57BL/6  
polypeptide P30412 UniProt | EBI | MGI Sequence Detail 212 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000013077 eukaryotic-type peptidyl-prolyl cis-trans isomerase C
  • PDB
  • EC
  • InterPro Domains
    IPR029000 Cyclophilin-like domain superfamily
    IPR024936 Cyclophilin-type peptidyl-prolyl cis-trans isomerase
    IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
    IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
Molecular
Reagents
less
  • All nucleic 69
    cDNA 69

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13593
References
more
  • Summaries
    All 34
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 4
  • Earliest
    J:17287 Friedman J, et al., Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: one in the presence and one in the absence of CsA. Cell. 1991 Aug 23;66(4):799-806
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory