Ppib
Gene Detail

Symbol Name ID

Ppib peptidylprolyl isomerase B MGI:97750

Synonyms

Cphn2, Cphn-2, cyclophilin B, CyP-20b

Feature Type

protein coding gene

Genetic Map

Chromosome 9

35.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:66060169-66066629 bp, + strand From NCBI annotation of GRCm38   6461 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:726  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Peptidylpro_ismrse
Gene Tree: Ppib

Human homologs

Human Homolog		PPIB, peptidylprolyl isomerase B (cyclophilin B)
NCBI Gene ID		5479
neXtProt AC		NX_P23284
Human Synonyms		CYPB, CYP-S1, OI9, SCYLP
Human Chr (Location)		15q21-q22; chr15:64448014-64455354 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PPIB

Alleles and phenotypes

All alleles(24) : Targeted(4) Gene trapped(20)
 

Homozygotes for a targeted null mutation developed kyphosis and severe osteoporosis.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	protein folding
Component	endoplasmic reticulum
Function	isomerase activity, peptide binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (40)    Tissues (9)    Images (18)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	40

cDNA source data(201)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(203) cDNA(201) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000032383 (Evidence)
Entrez Gene	19035 (Evidence)
UniGene	335249
DFCI	TC1572447, TC1604086
DoTS	DT.101136010, DT.102554125, DT.493355, DT.94408100
NIA Mouse Gene Index	U010652
EC	5.2.1.8
Consensus CDS Project	CCDS23301.1
International Mouse Knockout Project Status	Ppib

Sequences

Length	Strain/Species
genomic	19035	NCBI Gene Model | MGI Sequence Detail	6461	C57BL/6J
transcript	NM_011149	RefSeq | MGI Sequence Detail	979	C57BL/6
polypeptide	P24369	UniProt | EBI | MGI Sequence Detail	216	Not Applicable

All sequences(29) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(44 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002130	Cyclophilin-like peptidyl-prolyl cis-trans isomerase domain
InterPro	IPR024936	Cyclophilin-type peptidyl-prolyl cis-trans isomerase
InterPro	IPR020892	Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
Protein Ontology	PR:000013076	peptidyl-prolyl cis-trans isomerase B

Graphical View of Protein Domain Structure

References

(Earliest) J:2339 Schumacher A, et al., Murine cyclophilin-S1: a variant peptidyl-prolyl isomerase with a putative signal sequence expressed in differentiating F9 cells. Biochim Biophys Acta. 1991 Dec 2;1129(1):13-22
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(42)

Other accession IDs

MGD-MRK-13592, MGD-MRK-2109, MGD-MRK-2110, MGI:2142929, MGI:2142956, MGI:2143139