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Ppib Gene Detail
Summary
  • Symbol
    Ppib
  • Name
    peptidylprolyl isomerase B
  • Synonyms
    Cphn2, Cphn-2, cyclophilin B, CyP-20b
  • Feature Type
    protein coding gene
  • IDs
    MGI:97750
    NCBI Gene: 19035
  • Gene Overview
    MyGene.info: PPIB
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:66060222-66066623 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6402 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 35.69 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PPIB, peptidylprolyl isomerase B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPIB, peptidylprolyl isomerase B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    B, CYPB, CYP-S1, HEL-S-39, OI9, SCYLP
  • Links
    NCBI Gene ID: 5479
    neXtProt AC: NX_P23284
    UniProt: P23284

  • Chr Location
    15q22.31; chr15:64155815-64163155 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Ppib mouse models; 1 with human PPIB associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 2 alleles in 2 genetic backgrounds
    5 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a null mutations develop kyphosis and severe osteoporosis. Bone structure abnormalities are also seen in the trabecular and cortical regions of the long bones. Bone mineral density is reduced, and bones have reduced strength and are susceptible to fractures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032383 Ensembl Gene Model | MGI Sequence Detail 6402 C57BL/6J ±  kb
    transcript ENSMUST00000034947 Ensembl | MGI Sequence Detail 892 Not Applicable  
    polypeptide ENSMUSP00000034947 Ensembl | MGI Sequence Detail 216 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      64 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000013076 eukaryotic peptidyl-prolyl cis-trans isomerase B
    • EC
    • InterPro Domains
      IPR029000 Cyclophilin-like domain superfamily
      IPR024936 Cyclophilin-type peptidyl-prolyl cis-trans isomerase
      IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
      IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
    Molecular
    Reagents
    less
    • All nucleic 200
      cDNA 198
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13592, MGD-MRK-2109, MGD-MRK-2110, MGI:2142929, MGI:2142956, MGI:2143139
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 4
      Diseases 2
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:2339 Schumacher A, et al., Murine cyclophilin-S1: a variant peptidyl-prolyl isomerase with a putative signal sequence expressed in differentiating F9 cells. Biochim Biophys Acta. 1991 Dec 2;1129(1):13-22
    • Latest
      J:245009 Himmels P, et al., Motor neurons control blood vessel patterning in the developing spinal cord. Nat Commun. 2017 Mar 06;8:14583

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory