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Ppib Gene Detail
Summary
  • Symbol
    Ppib
  • Name
    peptidylprolyl isomerase B
  • Synonyms
    Cphn2, Cphn-2, cyclophilin B, CyP-20b
  • Feature Type
    protein coding gene
  • IDs
    MGI:97750
    NCBI Gene: 19035
  • Gene Overview
    MyGene.info: PPIB
Location & Maps
more
  • Sequence Map
    Chr9:66060169-66066629 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6461 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 35.69 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PPIB, peptidylprolyl isomerase B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPIB, peptidylprolyl isomerase B
    Orthology source: HomoloGene
  • Synonyms
    CYPB, CYP-S1, HEL-S-39, OI9, SCYLP
  • Links
    NCBI Gene ID: 5479
    neXtProt AC: NX_P23284

  • Chr Location
    15q21-q22; chr15:64155815-64163155 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Ppib mouse models; 1 with human PPIB associations

Human Disease Mouse Models
       Osteogenesis Imperfecta, Type IX; OI9   OMIM: 259440 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 2 alleles in 2 genetic backgrounds
    5 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    25
  • Chemically induced (other)
    1
  • Gene trapped
    20
  • Targeted
    4
  • Genomic Mutations
    1 involving Ppib
  • Incidental Mutations
Homozygotes for a null mutations develop kyphosis and severe osteoporosis. Bone structure abnormalities are also seen in the trabecular and cortical regions of the long bones. Bone mineral density is reduced, and bones have reduced strength and are susceptible to fractures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19035 NCBI Gene Model | MGI Sequence Detail 6461 C57BL/6J ±  kb
transcript NM_011149 RefSeq | MGI Sequence Detail 979 C57BL/6  
polypeptide P24369 UniProt | EBI | MGI Sequence Detail 216 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    64 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013076 eukaryotic peptidyl-prolyl cis-trans isomerase B
  • EC
  • InterPro Domains
    IPR029000 Cyclophilin-like domain
    IPR024936 Cyclophilin-type peptidyl-prolyl cis-trans isomerase
    IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
    IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
Molecular
Reagents
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  • All nucleic 199
    cDNA 197
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-13592, MGD-MRK-2109, MGD-MRK-2110, MGI:2142929, MGI:2142956, MGI:2143139
References
more
  • Summaries
    All 45
    Developmental Gene Expression 3
    Diseases 2
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:2339 Schumacher A, et al., Murine cyclophilin-S1: a variant peptidyl-prolyl isomerase with a putative signal sequence expressed in differentiating F9 cells. Biochim Biophys Acta. 1991 Dec 2;1129(1):13-22
  • Latest
    J:233710 Terajima M, et al., Cyclophilin-B Modulates Collagen Cross-linking by Differentially Affecting Lysine Hydroxylation in the Helical and Telopeptidyl Domains of Tendon Type I Collagen. J Biol Chem. 2016 Apr 29;291(18):9501-12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory