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Ppib
Gene Detail
 Symbol
Name
ID
Ppib
peptidylprolyl isomerase B
MGI:97750
Synonyms Cphn2, Cphn-2, cyclophilin B, CyP-20b
Feature Type protein coding gene
Genetic Map
Chromosome 9
35.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:66060169-66066629 bp, + strand
From NCBI annotation of GRCm38

  6461 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:726  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Peptidylpro_ismrse
Gene Tree: Ppib

Human
homologs
Human Homolog PPIB, peptidylprolyl isomerase B (cyclophilin B)
NCBI Gene ID 5479
neXtProt AC  NX_P23284
Human Synonyms  CYPB, CYP-S1, HEL-S-39, OI9, SCYLP
Human Chr (Location)  15q21-q22; chr15:64155815-64163155 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PPIB
Alleles
and
phenotypes
All alleles(24) : Gene trapped(20) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation developed kyphosis and severe osteoporosis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process bone development, positive regulation of multicellular organism growth, ...
Component endoplasmic reticulum, extracellular vesicular exosome, ...
Function isomerase activity, peptide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (40)    Tissues (9)    Images (18)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 40
cDNA source data(197)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(199) cDNA(197) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000032383 (Evidence)
Entrez Gene19035 (Evidence)
UniGene335249
DFCITC1572447, TC1604086
DoTSDT.101136010, DT.102554125, DT.493355, DT.94408100
NIA Mouse Gene IndexU010652
EC5.2.1.8
Consensus CDS ProjectCCDS23301.1
International Mouse Knockout Project StatusPpib
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19035 NCBI Gene Model | MGI Sequence Detail 6461 C57BL/6J ±  kb
transcript NM_011149 RefSeq | MGI Sequence Detail 979 C57BL/6 
polypeptide P24369 UniProt | EBI | MGI Sequence Detail 216 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(64 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002130 Cyclophilin-like peptidyl-prolyl cis-trans isomerase domain
InterPro IPR024936 Cyclophilin-type peptidyl-prolyl cis-trans isomerase
InterPro IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
Protein Ontology PR:000013076 peptidyl-prolyl cis-trans isomerase B
Graphical View of Protein Domain Structure
References (Earliest) J:2339 Schumacher A, et al., Murine cyclophilin-S1: a variant peptidyl-prolyl isomerase with a putative signal sequence expressed in differentiating F9 cells. Biochim Biophys Acta. 1991 Dec 2;1129(1):13-22
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(44)
Other
accession IDs
MGD-MRK-13592, MGD-MRK-2109, MGD-MRK-2110, MGI:2142929, MGI:2142956, MGI:2143139

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory