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Ppib
Gene Detail
Symbol

Name
ID
Ppib
peptidylprolyl isomerase B
MGI:97750
Synonyms
Cphn2, Cphn-2, cyclophilin B, CyP-20b
Feature Type
protein coding gene
Genetic Map
Chromosome 9
35.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:66060169-66066629 bp, + strand
From NCBI annotation of GRCm38

  6461 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:726  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PPIB
Protein SuperFamily: Peptidylpro_ismrse
Gene Tree: Ppib

Human
homologs
PPIB, peptidylprolyl isomerase B (cyclophilin B)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5479
neXtProt AC: NX_P23284

Human Synonyms: CYPB, CYP-S1, HEL-S-39, OI9, SCYLP

Human Chr (Location): 15q21-q22; chr15:64155815-64163155 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PPIB

Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(20) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation developed kyphosis and severe osteoporosis.
 
Interactions
Ppib interacts with 26 markers (Mir1a-1, Mir1a-2, Mir19a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (40)    Tissues (9)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 40
cDNA source data(197)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ppib ; ZFIN ppib    NEW 
Molecular
reagents
All nucleic(199) cDNA(197) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000032383 (Evidence)
Entrez Gene 19035 (Evidence)
UniGene 335249
DFCI TC1572447, TC1604086
DoTS DT.101136010, DT.102554125, DT.493355, DT.94408100
NIA Mouse Gene Index U010652
EC 5.2.1.8
Consensus CDS Project CCDS23301.1
International Mouse Phenotyping Consortium Status Ppib
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19035 NCBI Gene Model | MGI Sequence Detail 6461 C57BL/6J ±  kb
transcript NM_011149 RefSeq | MGI Sequence Detail 979 C57BL/6 
polypeptide P24369 UniProt | EBI | MGI Sequence Detail 216 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(64 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002130 Cyclophilin-like peptidyl-prolyl cis-trans isomerase domain
InterPro IPR024936 Cyclophilin-type peptidyl-prolyl cis-trans isomerase
InterPro IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
Protein Ontology PR:000013076 peptidyl-prolyl cis-trans isomerase B
Graphical View of Protein Domain Structure
References
(Earliest) J:2339 Schumacher A, et al., Murine cyclophilin-S1: a variant peptidyl-prolyl isomerase with a putative signal sequence expressed in differentiating F9 cells. Biochim Biophys Acta. 1991 Dec 2;1129(1):13-22
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(44)
Other
accession IDs
MGD-MRK-13592, MGD-MRK-2109, MGD-MRK-2110, MGI:2142929, MGI:2142956, MGI:2143139

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory