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Por Gene Detail
Summary
  • Symbol
    Por
  • Name
    P450 (cytochrome) oxidoreductase
  • Synonyms
    4933424M13Rik, CPR, CYPOR, NADH cytochrome P450 oxydoreductase
  • Feature Type
    protein coding gene
  • IDs
    MGI:97744
    NCBI Gene: 18984
  • Gene Overview
    MyGene.info: POR
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:135670040-135735326 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 75.34 cM, cytoband G1
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    396 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97744
protein coding gene Chr5:135670033-135735326 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030187
protein coding gene Chr5:140240491-140313584 (+)
A/J MGP_AJ_G0030155
protein coding gene Chr5:134222212-134290534 (+)
AKR/J MGP_AKRJ_G0030088
protein coding gene Chr5:138570442-138635392 (+)
BALB/cJ MGP_BALBcJ_G0030165
protein coding gene Chr5:135575936-135642550 (+)
C3H/HeJ MGP_C3HHeJ_G0029881
protein coding gene Chr5:139139811-139218658 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030618
protein coding gene Chr5:145465202-145542564 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027841
protein coding gene Chr5:128508538-128575230 (+)
CAST/EiJ MGP_CASTEiJ_G0029290
protein coding gene Chr5:138545992-138624677 (+)
CBA/J MGP_CBAJ_G0029851
protein coding gene Chr5:151135035-151206460 (+)
DBA/2J MGP_DBA2J_G0030002
protein coding gene Chr5:134118076-134184791 (+)
FVB/NJ MGP_FVBNJ_G0029957
protein coding gene Chr5:133265662-133332030 (+)
LP/J MGP_LPJ_G0030091
protein coding gene Chr5:140676572-140747843 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029989
protein coding gene Chr5:154139661-154215360 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030658
protein coding gene Chr5:138349701-138423460 (+)
PWK/PhJ MGP_PWKPhJ_G0029005
protein coding gene Chr5:133160433-133240253 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028840
protein coding gene Chr5:135885977-135955236 (+)
WSB/EiJ MGP_WSBEiJ_G0029364
protein coding gene Chr5:139076102-139147702 (+)



Homology
more
  • Human Ortholog
    POR, cytochrome p450 oxidoreductase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    POR, cytochrome p450 oxidoreductase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CPR, CYPOR, P450R
  • Links
    NCBI Gene ID: 5447
    neXtProt AC: NX_P16435
    UniProt: P16435

  • Chr Location
    7q11.23; chr7:75915102-75986855 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 725
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: POR
  • Protein SuperFamily
  • Gene Tree
    Por
Human Diseases
more
  • Diseases
    1 with human POR associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    58 phenotypes from 6 alleles in 7 genetic backgrounds
    14 phenotypes from multigenic genotypes
    4 images
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit defects of the neural tube, eye, heart, and limbs, retarded growth, and prenatal lethality. Liver-specific knockouts exhibit increased liver weight, hepatic lipidosis, and impaired drug metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18984 NCBI Gene Model | MGI Sequence Detail 65287 C57BL/6J ±  kb
    transcript NM_008898 RefSeq | MGI Sequence Detail 2527 C57BL/6  
    polypeptide P37040 UniProt | EBI | MGI Sequence Detail 678 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000013030 NADPH--cytochrome P450 reductase
    • EC
    • InterPro Domains
      IPR017927 FAD-binding domain, ferredoxin reductase-type
      IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
      IPR001094 Flavodoxin-like
      IPR008254 Flavodoxin/nitric oxide synthase
      IPR029039 Flavoprotein-like superfamily
      IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
      IPR023208 NADPH-cytochrome P450 reductase
      IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily
      IPR001433 Oxidoreductase FAD/NAD(P)-binding
      IPR017938 Riboflavin synthase-like beta-barrel
      IPR003097 Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding
    Molecular
    Reagents
    less
    • All nucleic 192
      cDNA 189
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13585, MGI:1921707
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 14
      Diseases 1
      Gene Ontology 6
      Phenotypes 43
    • Earliest
      J:6737 Gonzalez FJ, et al., Cloning of DNA complementary to rat liver NADPH-cytochrome c (P-450) oxidoreductase and cytochrome P-450b mRNAs. Evidence that phenobarbital augments transcription of specific genes. J Biol Chem. 1982 May 25;257(10):5962-8
    • Latest
      J:249535 Barzi M, et al., A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism. Nat Commun. 2017 Jun 28;8(1):39

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory