Por
Gene Detail

Symbol Name ID

Por P450 (cytochrome) oxidoreductase MGI:97744

Synonyms

4933424M13Rik, CPR, CYPOR, NADH cytochrome P450 oxydoreductase

Feature Type

protein coding gene

Genetic Map

Chromosome 5

75.34 cM, cytoband G1
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr5:135670033-135735326 bp, + strand From VEGA annotation of GRCm38   65294 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:725  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: P450R
Gene Tree: Por

Human homologs

Human Homolog		POR, P450 (cytochrome) oxidoreductase
NCBI Gene ID		5447
neXtProt AC		NX_P16435
Human Synonyms		CPR, CYPOR, P450R
Human Chr (Location)		7q11.2; chr7:75544420-75616173 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human POR

Alleles and phenotypes

All alleles(79) : Targeted(8) Gene trapped(71)
 

Homozygotes for targeted null mutations exhibit defects of the neural tube, eye, heart, and limbs, retarded growth, and prenatal lethality. Liver-specific knockouts exhibit increased liver weight, hepatic lipidosis, and impaired drug metabolism.

 
Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (40 annotations)

Process	cellular organofluorine metabolic process, demethylation, ...
Component	cytosol, endoplasmic reticulum, ...
Function	cytochrome-b5 reductase activity, acting on NAD(P)H, electron carrier activity, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (215)    Tissues (123)    Images (42)
Theiler Stages: 4, 22, 23, 28

Assay Type	Results
RNA in situ	212
RT-PCR	3

cDNA source data(184)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(190) cDNA(188) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000029621 (Evidence)
Ensembl Gene Model	ENSMUSG00000005514 (Evidence)
Entrez Gene	18984 (Evidence)
UniGene	3863
DFCI	TC1576420, TC1765981
DoTS	DT.101709390, DT.534100
NIA Mouse Gene Index	U006288
EC	1.6.2.4
Consensus CDS Project	CCDS39318.1
International Mouse Knockout Project Status	Por

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029621	VEGA Gene Model | MGI Sequence Detail	65294	C57BL/6J
transcript	OTTMUST00000073476	VEGA | MGI Sequence Detail	2636	Not Applicable
polypeptide	OTTMUSP00000038028	VEGA | MGI Sequence Detail	678	Not Applicable

All sequences(57) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(290 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003097	FAD-binding, type 1
InterPro	IPR017927	Ferredoxin reductase-type FAD-binding domain
InterPro	IPR001094	Flavodoxin
InterPro	IPR008254	Flavodoxin/nitric oxide synthase
InterPro	IPR001709	Flavoprotein pyridine nucleotide cytochrome reductase
InterPro	IPR023208	NADPH-cytochrome P450 reductase
InterPro	IPR023173	NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain-3
InterPro	IPR001433	Oxidoreductase FAD/NAD(P)-binding
InterPro	IPR017938	Riboflavin synthase-like beta-barrel
Protein Ontology	PR:000013030	NADPH--cytochrome P450 reductase

References

(Earliest) J:6737 Gonzalez FJ, et al., Cloning of DNA complementary to rat liver NADPH-cytochrome c (P-450) oxidoreductase and cytochrome P-450b mRNAs. Evidence that phenobarbital augments transcription of specific genes. J Biol Chem. 1982 May 25;257(10):5962-8
(Latest) J:192427 Fang C, et al., Neurobehavioral abnormalities in a brain-specific NADPH-cytochrome P450 reductase knockout mouse model. Neuroscience. 2012 Aug 30;218:170-80
All references(81)

Other accession IDs

MGD-MRK-13585, MGI:1921707