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Por Gene Detail
Summary
  • Symbol
    Por
  • Name
    P450 (cytochrome) oxidoreductase
  • Synonyms
    4933424M13Rik, CPR, CYPOR, NADH cytochrome P450 oxydoreductase
  • Feature Type
    protein coding gene
  • IDs
    MGI:97744
    NCBI Gene: 18984
Location & Maps
more
  • Sequence Map
    Chr5:135670033-135735326 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      65294 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    POR, P450 (cytochrome) oxidoreductase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    POR, P450 (cytochrome) oxidoreductase
    Orthology source: HomoloGene
  • Synonyms
    CPR, CYPOR, P450R
  • Links
    NCBI Gene ID: 5447
    neXtProt AC: NX_P16435

  • Chr Location
    7q11.2; chr7:75915102-75986855 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 725
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: POR
  • Protein SuperFamily
  • Gene Tree
    Por
Human Diseases
more
  • Diseases
    3 with human POR associations
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    57 phenotypes from 6 alleles in 7 genetic backgrounds
    14 phenotypes from multigenic genotypes
    4 images
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit defects of the neural tube, eye, heart, and limbs, retarded growth, and prenatal lethality. Liver-specific knockouts exhibit increased liver weight, hepatic lipidosis, and impaired drug metabolism.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029621 VEGA Gene Model | MGI Sequence Detail 65294 C57BL/6J ±  kb
transcript OTTMUST00000073476 VEGA | MGI Sequence Detail 2636 Not Applicable  
polypeptide OTTMUSP00000038028 VEGA | MGI Sequence Detail 678 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    415 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000013030 NADPH--cytochrome P450 reductase
  • EC
  • InterPro Domains
    IPR003097 FAD-binding, type 1
    IPR017927 Ferredoxin reductase-type FAD-binding domain
    IPR001094 Flavodoxin-like
    IPR008254 Flavodoxin/nitric oxide synthase
    IPR029039 Flavoprotein-like domain
    IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
    IPR023208 NADPH-cytochrome P450 reductase
    IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain-3
    IPR001433 Oxidoreductase FAD/NAD(P)-binding
    IPR017938 Riboflavin synthase-like beta-barrel
Molecular
Reagents
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  • All nucleic 189
    cDNA 187
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-13585, MGI:1921707
References
more
  • Summaries
    All 86
    Developmental Gene Expression 13
    Diseases 1
    Gene Ontology 6
    Phenotypes 42
  • Earliest
    J:6737 Gonzalez FJ, et al., Cloning of DNA complementary to rat liver NADPH-cytochrome c (P-450) oxidoreductase and cytochrome P-450b mRNAs. Evidence that phenobarbital augments transcription of specific genes. J Biol Chem. 1982 May 25;257(10):5962-8
  • Latest
    J:218526 Henderson CJ, et al., Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability. Biochem J. 2015 Feb 1;465(3):479-88

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory