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Por
Gene Detail
 Symbol
Name
ID
Por
P450 (cytochrome) oxidoreductase
MGI:97744
Synonyms 4933424M13Rik, CPR, CYPOR, NADH cytochrome P450 oxydoreductase
Feature Type protein coding gene
Genetic Map
Chromosome 5
75.34 cM, cytoband G1
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr5:135670033-135735326 bp, + strand
From VEGA annotation of GRCm38

  65294 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:725  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: P450R
Gene Tree: Por

Human
homologs
Human Homolog POR, P450 (cytochrome) oxidoreductase
NCBI Gene ID 5447
neXtProt AC  NX_P16435
Human Synonyms  CPR, CYPOR, P450R
Human Chr (Location)  7q11.2; chr7:75915102-75986855 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human POR
Mutations,
alleles, and
phenotypes
All mutations/alleles(79) : Gene trapped(71) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit defects of the neural tube, eye, heart, and limbs, retarded growth, and prenatal lethality. Liver-specific knockouts exhibit increased liver weight, hepatic lipidosis, and impaired drug metabolism.
 
Phenotype Images(4)
Interactions
Por interacts with 91 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process cellular organofluorine metabolic process, demethylation, ...
Component cytosol, endoplasmic reticulum, ...
Function cytochrome-b5 reductase activity, acting on NAD(P)H, electron carrier activity, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (256)    Tissues (164)    Images (44)
Theiler Stages: 4, 22, 23, 26, 28
Assay TypeResults
RNA in situ 254
RT-PCR 2
cDNA source data(183)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(189) cDNA(187) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000029621 (Evidence)
Ensembl Gene ModelENSMUSG00000005514 (Evidence)
Entrez Gene18984 (Evidence)
UniGene3863
DFCITC1576420, TC1765981
DoTSDT.101709390, DT.534100
NIA Mouse Gene IndexU006288
EC1.6.2.4
Consensus CDS ProjectCCDS39318.1
International Mouse Knockout Project StatusPor
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029621 VEGA Gene Model | MGI Sequence Detail 65294 C57BL/6J ±  kb
transcript OTTMUST00000073476 VEGA | MGI Sequence Detail 2636 Not Applicable 
polypeptide OTTMUSP00000038028 VEGA | MGI Sequence Detail 678 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(6) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(415 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003097 FAD-binding, type 1
InterPro IPR017927 Ferredoxin reductase-type FAD-binding domain
InterPro IPR001094 Flavodoxin
InterPro IPR008254 Flavodoxin/nitric oxide synthase
InterPro IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
InterPro IPR023208 NADPH-cytochrome P450 reductase
InterPro IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain-3
InterPro IPR001433 Oxidoreductase FAD/NAD(P)-binding
InterPro IPR017938 Riboflavin synthase-like beta-barrel
Protein Ontology PR:000013030 NADPH--cytochrome P450 reductase
References (Earliest) J:6737 Gonzalez FJ, et al., Cloning of DNA complementary to rat liver NADPH-cytochrome c (P-450) oxidoreductase and cytochrome P-450b mRNAs. Evidence that phenobarbital augments transcription of specific genes. J Biol Chem. 1982 May 25;257(10):5962-8
(Latest) J:211581 Kunne C, et al., FXR-dependent reduction of hepatic steatosis in a bile salt deficient mouse model. Biochim Biophys Acta. 2014 May;1842(5):739-46
All references(89)
Other
accession IDs
MGD-MRK-13585, MGI:1921707

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory