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Polb Gene Detail
Summary
  • Symbol
    Polb
  • Name
    polymerase (DNA directed), beta
  • Synonyms
    A430088C08Rik, Pol beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:97740
    NCBI Gene: 18970
  • Gene Overview
    MyGene.info: POLB
Location & Maps
more
  • Sequence Map
    Chr8:22628126-22653435 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25310 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 11.42 cM
  • Mapping Data
    17 experiments
  • Sequence Tags
Homology
more
  • Human Ortholog
    POLB, DNA polymerase beta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    POLB, DNA polymerase beta
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 5423
    neXtProt AC: NX_P06746

  • Chr Location
    8p11.2; chr8:42338455-42371813 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Polb mouse models

Human Disease Mouse Models
       Systemic Lupus Erythematosus; SLE   OMIM: 152700 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    44 phenotypes from 5 alleles in 5 genetic backgrounds
    2 images
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Targeted
    7
  • Transgenic
    1
  • Incidental Mutations
Homozygotes for one knock-out allele die from E10.5 to birth and those for another one exhibit embryonic growth retardation, abnormal neurogenesis, and neonatal lethality due to respiratory failure. Hypomorphic allele mice develop systemic lupus erythematosus-like phentoypes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000060893 VEGA Gene Model | MGI Sequence Detail 25310 C57BL/6J ±  kb
transcript OTTMUST00000148815 VEGA | MGI Sequence Detail 1201 Not Applicable  
polypeptide OTTMUSP00000077310 VEGA | MGI Sequence Detail 335 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    41 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    Genomic 2
    cDNA 12
    Primer pair 4

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-13578, MGI:2444980
References
more
  • Summaries
    All 84
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 12
    Phenotypes 31
  • Earliest
    J:14794 Yamaguchi M, et al., Murine DNA polymerase beta gene: mapping of transcription initiation sites and the nucleotide sequence of the putative promoter region. Mol Cell Biol. 1987 May;7(5):2012-8
  • Latest
    J:224693 Lokanga RA, et al., Heterozygosity for a hypomorphic Polbeta mutation reduces the expansion frequency in a mouse model of the Fragile X-related disorders. PLoS Genet. 2015 Apr;11(4):e1005181

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory