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Pnlip Gene Detail
Summary
  • Symbol
    Pnlip
  • Name
    pancreatic lipase
  • Synonyms
    1810007A24Rik, MGC:74173, pancreatic triglyceride lipase, PTL
  • Feature Type
    protein coding gene
  • IDs
    MGI:97722
    NCBI Gene: 69060
Location & Maps
more
  • Sequence Map
    Chr19:58670365-58681786 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11422 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PNLIP, pancreatic lipase
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PNLIP, pancreatic lipase
    Orthology source: HomoloGene
  • Synonyms
    PL, PNLIPD, PTL
  • Links
    NCBI Gene ID: 5406
    neXtProt AC: NX_P16233

  • Chr Location
    10q26.1; chr10:116545916-116567855 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PNLIP associations

Human Disease Mouse Models
       Pancreatic Lipase Deficiency; PNLIPD   OMIM: 614338
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous null mice show impaired dietary cholesterol, triglyceride and retinyl ester absorption, resistance to diet-induced obesity, and insulin resistance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046008 Ensembl Gene Model | MGI Sequence Detail 11422 C57BL/6J ±  kb
transcript ENSMUST00000057270 Ensembl | MGI Sequence Detail 1485 Not Applicable  
polypeptide ENSMUSP00000056377 Ensembl | MGI Sequence Detail 465 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    60 from dbSNP Build 137
  • RFLP
Protein
Information
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Molecular
Reagents
less
  • All nucleic 335
    cDNA 334
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-13544, MGI:1916310
References
more
  • Summaries
    All 40
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:43376 Grusby MJ, et al., Cloning of an interleukin-4 inducible gene from cytotoxic T lymphocytes and its identification as a lipase. Cell. 1990 Feb 9;60(3):451-9
  • Latest
    J:214089 Hale MA, et al., The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis. Development. 2014 Aug;141(16):3123-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory