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Pnlip
Gene Detail
Symbol

Name
ID
Pnlip
pancreatic lipase
MGI:97722
Synonyms
1810007A24Rik, MGC:74173, pancreatic triglyceride lipase, PTL
Feature Type
protein coding gene
Genetic Map
Chromosome 19
54.46 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr19:58670365-58681786 bp, + strand
From Ensembl annotation of GRCm38

  11422 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30999  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: lipoprotein lipase, LIPH type
Gene Tree: Pnlip

Human
homologs
Human Homolog PNLIP, pancreatic lipase
NCBI Gene ID 5406
neXtProt AC  NX_P16233
Human Synonyms  PL, PNLIPD, PTL
Human Chr (Location)  10q26.1; chr10:116545916-116567855 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PNLIP
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix )
 
Homozygous null mice show impaired dietary cholesterol, triglyceride and retinyl ester absorption, resistance to diet-induced obesity, and insulin resistance.
 
Interactions
Pnlip interacts with 27 markers (Mir103-2, Mir107, Mir136, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process intestinal cholesterol absorption, lipid catabolic process, ...
Component extracellular region, extracellular space
Function carboxylic ester hydrolase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (98)    Tissues (96)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 98
cDNA source data(332)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(335) cDNA(334) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000046008 (Evidence)
Entrez Gene69060 (Evidence)
UniGene20407
DFCITC1571871, TC1595936
DoTSDT.526226, DT.91481871
NIA Mouse Gene IndexU052115
EC3.1.1.3
Consensus CDS ProjectCCDS29930.1
International Mouse Knockout Project StatusPnlip
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046008 Ensembl Gene Model | MGI Sequence Detail 11422 C57BL/6J ±  kb
transcript ENSMUST00000057270 Ensembl | MGI Sequence Detail 1485 Not Applicable 
polypeptide ENSMUSP00000056377 Ensembl | MGI Sequence Detail 465 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(60 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000734 Lipase
InterPro IPR008976 Lipase/lipooxygenase, PLAT/LH2
InterPro IPR013818 Lipase, N-terminal
InterPro IPR016272 Lipoprotein lipase, LIPH
InterPro IPR001024 Lipoxygenase, LH2
InterPro IPR002331 Pancreatic lipase
Protein Ontology PR:000012925 pancreatic triacylglycerol lipase
References
(Earliest) J:43376 Grusby MJ, et al., Cloning of an interleukin-4 inducible gene from cytotoxic T lymphocytes and its identification as a lipase. Cell. 1990 Feb 9;60(3):451-9
(Latest) J:214089 Hale MA, et al., The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis. Development. 2014 Aug;141(16):3123-33
All references(43)
Other
accession IDs
MGD-MRK-13544, MGI:1916310

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory