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Pmch
Gene Detail
Symbol

Name
ID
Pmch
pro-melanin-concentrating hormone
MGI:97629
Synonyms
A230109K23Rik, MCH, melanin-concentrating hormone
Feature Type
protein coding gene
Genetic Map
Chromosome 10
43.70 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:88091072-88092375 bp, + strand
From VEGA annotation of GRCm38

  1304 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37653  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: PMCH
Protein SuperFamily: melanin-concentrating hormone
Gene Tree: Pmch

Human
homologs
PMCH, pro-melanin-concentrating hormone
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5367
neXtProt AC: NX_P20382

Human Synonyms: MCH, ppMCH

Human Chr (Location): 12q23.2; chr12:102196459-102197836 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene eat less than normal and display increased oxygen consumption, which together results in lower body weight.
 
Interactions
Pmch interacts with 30 markers (Mir27a, Mir141, Mir153, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process drinking behavior, feeding behavior, ...
Component cytosol, extracellular region, ...
Function hormone activity, melanin-concentrating hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (95)    Tissues (95)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 95
cDNA source data(20)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase pmch ; ZFIN pmch    NEW 
Molecular
reagents
All nucleic(23) Genomic(1) cDNA(21) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000035176 (Evidence)
Ensembl Gene Model ENSMUSG00000035383 (Evidence)
Entrez Gene 110312 (Evidence)
UniGene 391436
DoTS DT.40148247
NIA Mouse Gene Index U011855
Consensus CDS Project CCDS24105.1
International Mouse Phenotyping Consortium Status Pmch
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035176 VEGA Gene Model | MGI Sequence Detail 1304 C57BL/6J ±  kb
transcript OTTMUST00000089599 VEGA | MGI Sequence Detail 749 Not Applicable 
polypeptide OTTMUSP00000048991 VEGA | MGI Sequence Detail 165 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(3) : SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005456 Pre-pro melanin-concentrating hormone
Protein Ontology PR:000012901 pro-MCH
References
(Earliest) J:16566 Thompson RC, et al., Nucleotide sequence and tissue-specific expression of the rat melanin concentrating hormone gene. DNA Cell Biol. 1990 Nov;9(9):637-45
(Latest) J:221571 Sokolowski K, et al., Specification of select hypothalamic circuits and innate behaviors by the embryonic patterning gene dbx1. Neuron. 2015 Apr 22;86(2):403-16
All references(61)
Other
accession IDs
MGD-MRK-13369, MGI:1925014

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory