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Pmch
Gene Detail
Symbol

Name
ID
Pmch
pro-melanin-concentrating hormone
MGI:97629
Synonyms
A230109K23Rik, MCH, melanin-concentrating hormone
Feature Type
protein coding gene
Genetic Map
Chromosome 10
43.70 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:88091072-88092375 bp, + strand
From VEGA annotation of GRCm38

  1304 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37653  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: melanin-concentrating hormone
Gene Tree: Pmch

Human
homologs
Human Homolog PMCH, pro-melanin-concentrating hormone
NCBI Gene ID 5367
neXtProt AC  NX_P20382
Human Synonyms  MCH
Human Chr (Location)  12q23.2; chr12:102196459-102197836 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene eat less than normal and display increased oxygen consumption, which together results in lower body weight.
 
Interactions
Pmch interacts with 30 markers (Mir27a, Mir141, Mir153, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process drinking behavior, feeding behavior, ...
Component cell, cytosol, ...
Function hormone activity, melanin-concentrating hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (95)    Tissues (95)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 95
cDNA source data(20)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(1) cDNA(21) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000035176 (Evidence)
Ensembl Gene ModelENSMUSG00000035383 (Evidence)
Entrez Gene110312 (Evidence)
UniGene391436
DoTSDT.40148247
NIA Mouse Gene IndexU011855
Consensus CDS ProjectCCDS24105.1
International Mouse Knockout Project StatusPmch
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035176 VEGA Gene Model | MGI Sequence Detail 1304 C57BL/6J ±  kb
transcript OTTMUST00000089599 VEGA | MGI Sequence Detail 749 Not Applicable 
polypeptide OTTMUSP00000048991 VEGA | MGI Sequence Detail 165 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(3) : SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005456 Pre-pro melanin-concentrating hormone
Protein Ontology PR:000012901 pro-MCH
References
(Earliest) J:16566 Thompson RC, et al., Nucleotide sequence and tissue-specific expression of the rat melanin concentrating hormone gene. DNA Cell Biol. 1990 Nov;9(9):637-45
(Latest) J:194049 Johansson PA, et al., The transcription factor Otx2 regulates choroid plexus development and function. Development. 2013 Mar;140(5):1055-66
All references(60)
Other
accession IDs
MGD-MRK-13369, MGI:1925014

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory