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Plk1
Gene Detail
Symbol

Name
ID
Plk1
polo-like kinase 1
MGI:97621
Synonyms
Plk, STPK13
Feature Type
protein coding gene
Genetic Map
Chromosome 7
65.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr7:122159437-122169875 bp, + strand
From NCBI annotation of GRCm38

  10439 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3690  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PLK1
Gene Tree: Plk1

Human
homologs
PLK1, polo-like kinase 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5347
neXtProt AC: NX_P53350

Human Synonyms: PLK, STPK13

Human Chr (Location): 16p12.2; chr16:23678822-23690367 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(13) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display lethality before implantation, embryonic growth arrest, and impaired mitosis. Mice heterozygous for a null mutation display increased tumor incidence and increased incidence of aneuploidy.
 
Interactions
Plk1 interacts with 79 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (74 annotations)
Process activation of APC-Cdc20 complex activity, cell cycle, ...
Component centrosome, chromatin, ...
Function anaphase-promoting complex binding, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (118)    Tissues (105)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 106
Western blot 3
RT-PCR 9
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase plk1 ; ZFIN plk1    NEW 
Molecular
reagents
All nucleic(30) Genomic(7) cDNA(20) Primer pair(3)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000030867 (Evidence)
Entrez Gene 18817 (Evidence)
DFCI TC1572403, TC1649209
DoTS DT.101267993, DT.101392533, DT.493889, DT.97381715, DT.97391332
NIA Mouse Gene Index U008728, U048404
EC 2.7.11.21
Consensus CDS Project CCDS21812.1
International Mouse Phenotyping Consortium Status Plk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18817 NCBI Gene Model | MGI Sequence Detail 10439 C57BL/6J ±  kb
transcript NM_011121 RefSeq | MGI Sequence Detail 2203 C57BL/6 
polypeptide Q07832 UniProt | EBI | MGI Sequence Detail 603 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(168 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000959 POLO box duplicated domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000012870 serine/threonine-protein kinase PLK1
Graphical View of Protein Domain Structure
References
(Earliest) J:12876 Clay FJ, et al., Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila. Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):4882-6
(Latest) J:216866 Kim J, et al., Meikin is a conserved regulator of meiosis-I-specific kinetochore function. Nature. 2014 Dec 24;
All references(77)
Other
accession IDs
MGD-MRK-13361

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory