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Plk1 Gene Detail
Summary
  • Symbol
    Plk1
  • Name
    polo-like kinase 1
  • Synonyms
    Plk, STPK13
  • Feature Type
    protein coding gene
  • IDs
    MGI:97621
    NCBI Gene: 18817
  • Gene Overview
    MyGene.info: PLK1
Location & Maps
more
  • Sequence Map
    Chr7:122159439-122169873 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10435 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PLK1, polo like kinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLK1, polo like kinase 1
    Orthology source: HomoloGene
  • Synonyms
    PLK, STPK13
  • Links
    NCBI Gene ID: 5347
    neXtProt AC: NX_P53350

  • Chr Location
    16p12.2; chr16:23678822-23690367 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3690
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PLK1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Gene trapped
    13
  • Targeted
    3
  • Incidental Mutations
Mice homozygous for a null mutation display lethality before implantation, embryonic growth arrest, and impaired mitosis. Mice heterozygous for a null mutation display increased tumor incidence and increased incidence of aneuploidy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058103 VEGA Gene Model | MGI Sequence Detail 10435 C57BL/6J ±  kb
transcript OTTMUST00000142667 VEGA | MGI Sequence Detail 2199 Not Applicable  
polypeptide OTTMUSP00000074412 VEGA | MGI Sequence Detail 603 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    168 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 30
    Genomic 7
    cDNA 20
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-13361
References
more
  • Summaries
    All 77
    Developmental Gene Expression 19
    Gene Ontology 10
    Phenotypes 8
  • Earliest
    J:12876 Clay FJ, et al., Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila. Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):4882-6
  • Latest
    J:229046 Solc P, et al., Multiple requirements of PLK1 during mouse oocyte maturation. PLoS One. 2015;10(2):e0116783

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory