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Plcd1 Gene Detail
Summary
  • Symbol
    Plcd1
  • Name
    phospholipase C, delta 1
  • Synonyms
    PLC-delta 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97614
    NCBI Gene: 18799
  • Gene Overview
    MyGene.info: PLCD1
Location & Maps
more
  • Sequence Map
    Chr9:119071527-119093496 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21970 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PLCD1, phospholipase C delta 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PLCD1, phospholipase C delta 1
    Orthology source: HomoloGene
  • Synonyms
    NDNC3, PLC-III
  • Links
    NCBI Gene ID: 5333
    neXtProt AC: NX_P51178

  • Chr Location
    3p22-p21.3; chr3:38007496-38029663 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PLCD1 associations

Human Disease Mouse Models
       Nail Disorder, Nonsyndromic Congenital, 3; NDNC3   OMIM: 151600
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 2 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Endonuclease-mediated
    1
  • Gene trapped
    17
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Plcd1
  • Incidental Mutations
Mice homozygous for disruptions in this gene show reduced body size and various abnormalities of the skin and hair including alopecia, epidermal hyperplasia, enlarged sebaceous glands, various kinds of cysts, and skin tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000010660 Ensembl Gene Model | MGI Sequence Detail 21970 C57BL/6J ±  kb
transcript ENSMUST00000010804 Ensembl | MGI Sequence Detail 2651 Not Applicable  
polypeptide ENSMUSP00000010804 Ensembl | MGI Sequence Detail 756 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    179 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000012832 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
  • EC
  • InterPro Domains
    IPR028391 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
    IPR000008 C2 domain
    IPR018247 EF-Hand 1, calcium-binding site
    IPR002048 EF-hand domain
    IPR011992 EF-hand domain pair
    IPR011993 PH domain-like
    IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
    IPR001192 Phosphoinositide phospholipase C family
    IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domain
    IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
    IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
    IPR001849 Pleckstrin homology domain
Molecular
Reagents
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  • All nucleic 73
    cDNA 71
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-13352, MGI:2143300, MGI:2143410
References
more
  • Summaries
    All 51
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 26
  • Earliest
    J:30483 Hempel WM, et al., Expression of phospholipase C isozymes by murine B lymphocytes. J Immunol. 1991 Jun 1;146(11):3713-20
  • Latest
    J:202624 Kim NY, et al., PLC-delta1-Lf, a novel N-terminal extended phospholipase C-delta1. Gene. 2013 Oct 10;528(2):170-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory