Plcd1
Gene Detail

Symbol Name ID

Plcd1 phospholipase C, delta 1 MGI:97614

Synonyms

PLC-delta 1

Feature Type

protein coding gene

Genetic Map

Chromosome 9

71.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr9:119071527-119093496 bp, - strand From NCBI annotation of GRCm38   21970 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21252  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1
Gene Tree: Plcd1

Human homologs

Human Homolog		PLCD1, phospholipase C, delta 1
NCBI Gene ID		5333
neXtProt AC		NX_P51178
Human Synonyms		NDNC3, PLC-III
Human Chr (Location)		3p22-p21.3; chr3:38048987-38071154 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PLCD1

Alleles and phenotypes

All alleles(20) : Targeted(3) Gene trapped(17)
 

Mice homozygous for disruptions in this gene show reduced body size and various abnormalities of the skin and hair including alopecia, epidermal hyperplasia, enlarged sebaceous glands, various kinds of cysts, and skin tumors.

 

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	angiogenesis, elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway, ...
Component	cytoplasm, cytosol, ...
Function	calcium ion binding, GTPase activating protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (331)    Tissues (148)    Images (40)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	331

cDNA source data(71)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(73) cDNA(71) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000010660 (Evidence)
Entrez Gene	18799 (Evidence)
UniGene	23963
DFCI	TC1577651
DoTS	DT.101736163, DT.531486
NIA Mouse Gene Index	U031421
EC	3.1.4.11
Consensus CDS Project	CCDS23607.1
International Mouse Knockout Project Status	Plcd1

Sequences

Length	Strain/Species
genomic	18799	NCBI Gene Model | MGI Sequence Detail	21970	C57BL/6J
transcript	NM_019676	RefSeq | MGI Sequence Detail	2651	C57BL/6
polypeptide	Q8R3B1	UniProt | EBI | MGI Sequence Detail	756	Not Applicable

All sequences(26) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(76 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR008973	C2 calcium/lipid-binding domain, CaLB
InterPro	IPR018029	C2 membrane targeting protein
InterPro	IPR002048	Calcium-binding EF-hand
InterPro	IPR018247	EF-Hand 1, calcium-binding site
InterPro	IPR018249	EF-HAND 2
InterPro	IPR011992	EF-hand-like domain
InterPro	IPR001192	Phosphoinositide phospholipase C
InterPro	IPR000909	Phospholipase C, phosphatidylinositol-specific , X domain
InterPro	IPR001711	Phospholipase C, phosphatidylinositol-specific, Y domain
InterPro	IPR015359	Phospholipase C, phosphoinositol-specific, EF-hand-like
InterPro	IPR017946	PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
Protein Ontology	PR:000012832	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

Graphical View of Protein Domain Structure

References

(Earliest) J:30483 Hempel WM, et al., Expression of phospholipase C isozymes by murine B lymphocytes. J Immunol. 1991 Jun 1;146(11):3713-20
(Latest) J:186749 Hirata M, et al., Genetic defect in phospholipase Cdelta1 protects mice from obesity by regulating thermogenesis and adipogenesis. Diabetes. 2011 Jul;60(7):1926-37
All references(49)

Other accession IDs

MGD-MRK-13352, MGI:2143300, MGI:2143410