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Plcd1
Gene Detail
 Symbol
Name
ID
Plcd1
phospholipase C, delta 1
MGI:97614
Synonyms PLC-delta 1
Feature Type protein coding gene
Genetic Map
Chromosome 9
71.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr9:119071527-119093496 bp, - strand
From NCBI annotation of GRCm38

  21970 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21252  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1
Gene Tree: Plcd1

Human
homologs
Human Homolog PLCD1, phospholipase C, delta 1
NCBI Gene ID 5333
neXtProt AC  NX_P51178
Human Synonyms  NDNC3, PLC-III
Human Chr (Location)  3p22-p21.3; chr3:38007496-38029663 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PLCD1
Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(17) Spontaneous(1) Targeted(4)
Genomic Mutations involving Plcd1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene show reduced body size and various abnormalities of the skin and hair including alopecia, epidermal hyperplasia, enlarged sebaceous glands, various kinds of cysts, and skin tumors.
 
Interactions
Plcd1 interacts with 42 markers (Mir124a-1, Mir124a-2, Mir124a-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process angiogenesis, cytosolic calcium ion homeostasis, ...
Component cytoplasm, cytosol, ...
Function calcium ion binding, GTPase activating protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (331)    Tissues (148)    Images (40)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 331
cDNA source data(71)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(73) cDNA(71) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000010660 (Evidence)
Entrez Gene18799 (Evidence)
UniGene23963
DFCITC1577651, TC1695092
DoTSDT.101736163, DT.531486, DT.97370879
NIA Mouse Gene IndexU031421
EC3.1.4.11
Consensus CDS ProjectCCDS23607.1
International Mouse Knockout Project StatusPlcd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18799 NCBI Gene Model | MGI Sequence Detail 21970 C57BL/6J ±  kb
transcript NR_121571 RefSeq | MGI Sequence Detail 2715 C57BL/6 
polypeptide Q8R3B1 UniProt | EBI | MGI Sequence Detail 756 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(8) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(179 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR001192 Phosphoinositide phospholipase C
InterPro IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
InterPro IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
InterPro IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
InterPro IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000012832 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
Graphical View of Protein Domain Structure
References (Earliest) J:30483 Hempel WM, et al., Expression of phospholipase C isozymes by murine B lymphocytes. J Immunol. 1991 Jun 1;146(11):3713-20
(Latest) J:202624 Kim NY, et al., PLC-delta1-Lf, a novel N-terminal extended phospholipase C-delta1. Gene. 2013 Oct 10;528(2):170-7
All references(53)
Other
accession IDs
MGD-MRK-13352, MGI:2143300, MGI:2143410

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory