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Plaur Gene Detail
Summary
  • Symbol
    Plaur
  • Name
    plasminogen activator, urokinase receptor
  • Synonyms
    Cd87, uPAR, u-PAR, urokinase-type plasminogen activator receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:97612
    NCBI Gene: 18793
  • Gene Overview
    MyGene.info: PLAUR
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:24462484-24475968 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13485 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 10.92 cM, cytoband A3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PLAUR, plasminogen activator, urokinase receptor
  • Vertebrate Orthologs
    6
  • Human Ortholog
    PLAUR, plasminogen activator, urokinase receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD87, UPAR, U-PAR, URKR
  • Links
    NCBI Gene ID: 5329
    neXtProt AC: NX_Q03405
    UniProt: Q03405

  • Chr Location
    19q13.31; chr19:43646095-43670346 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 3 alleles in 7 genetic backgrounds
    2 phenotypes from multigenic genotypes
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele exhibit chronic inflammation, macrophage dysfunction, and reduced angiogenesis. Homozygotes for another null allele show neutrophil dysfunction, increased anxiety, loss of GABAergic neurons, myoclonus, and susceptibility to bacterial infection and PTZ -induced seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000058079 VEGA Gene Model | MGI Sequence Detail 13485 C57BL/6J ±  kb
    transcript OTTMUST00000142604 VEGA | MGI Sequence Detail 1506 Not Applicable  
    polypeptide OTTMUSP00000074385 VEGA | MGI Sequence Detail 327 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      152 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 2
      cDNA 34
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13348
    References
    more
    • Summaries
      All 131
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 7
      Phenotypes 73
    • Earliest
      J:2322 Kristensen P, et al., Two alternatively spliced mouse urokinase receptor mRNAs with different histological localization in the gastrointestinal tract. J Cell Biol. 1991 Dec;115(6):1763-71
    • Latest
      J:260798 Stavrou EX, et al., Factor XII and uPAR upregulate neutrophil functions to influence wound healing. J Clin Invest. 2018 Mar 1;128(3):944-959

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory