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Plaur
Gene Detail
Symbol

Name
ID
Plaur
plasminogen activator, urokinase receptor
MGI:97612
Synonyms
Cd87, uPAR, u-PAR, urokinase-type plasminogen activator receptor
Feature Type
protein coding gene
Genetic Map
Chromosome 7
10.92 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:24462500-24475873 bp, + strand
From NCBI annotation of GRCm38

  13374 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48120  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: urokinase plasminogen activator surface receptor
Gene Tree: Plaur

Human
homologs
Human Homolog PLAUR, plasminogen activator, urokinase receptor
NCBI Gene ID 5329
neXtProt AC  NX_Q03405
Human Synonyms  CD87, UPAR, U-PAR, URKR
Human Chr (Location)  19q13; chr19:43646095-43670346 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix )
 
Homozygotes for a null allele exhibit chronic inflammation, macrophage dysfunction, and reduced angiogenesis. Homozygotes for another null allele show neutrophil dysfunction, increased anxiety, loss of GABAergic neurons, myoclonus, and susceptibility to bacterial infection and PTZ -induced seizures.
 
Interactions
Plaur interacts with 54 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (29)    Tissues (24)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 15
RT-PCR 14
cDNA source data(33)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) Genomic(2) cDNA(34) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000046223 (Evidence)
Entrez Gene18793 (Evidence)
UniGene1359
DFCITC1581513, TC1588678, TC1653385
DoTSDT.101400634, DT.94308654, DT.97412079
NIA Mouse Gene IndexU007797
PDB3LAQ
Consensus CDS ProjectCCDS20950.1
International Mouse Knockout Project StatusPlaur
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18793 NCBI Gene Model | MGI Sequence Detail 13374 C57BL/6J ±  kb
transcript NM_011113 RefSeq | MGI Sequence Detail 1396 Not Specified 
polypeptide P35456 UniProt | EBI | MGI Sequence Detail 327 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(10) UniProt(5)
Polymorphisms
SNPs within 2kb(113 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001526 CD59 antigen
InterPro IPR018363 CD59 antigen, conserved site
InterPro IPR016054 Ly-6 antigen / uPA receptor -like
Protein Ontology PR:000001969 urokinase plasminogen activator surface receptor
Graphical View of Protein Domain Structure
References
(Earliest) J:2322 Kristensen P, et al., Two alternatively spliced mouse urokinase receptor mRNAs with different histological localization in the gastrointestinal tract. J Cell Biol. 1991 Dec;115(6):1763-71
(Latest) J:210232 Fleetwood AJ, et al., Urokinase plasminogen activator is a central regulator of macrophage three-dimensional invasion, matrix degradation, and adhesion. J Immunol. 2014 Apr 15;192(8):3540-7
All references(114)
Other
accession IDs
MGD-MRK-13348

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory