Plat
Gene Detail

Symbol Name ID

Plat plasminogen activator, tissue MGI:97610

Synonyms

D8Ertd2e, MGC:18508, tPA, t-PA

Feature Type

protein coding gene

Genetic Map

Chromosome 8

11.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(38)

Sequence Map

Chr8:22757744-22782847 bp, + strand From Ensembl annotation of GRCm38   25104 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:717  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tissue plasminogen activator
Gene Tree: Plat

Human homologs

Human Homolog		PLAT, plasminogen activator, tissue
NCBI Gene ID		5327
neXtProt AC		NX_P00750
Human Synonyms		TPA, T-PA
Human Chr (Location)		8p12; chr8:42032236-42065194 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PLAT

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a knock-out allele exhibit abnormal behavior, CNS synpatic transmission, and response to injury.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	negative regulation of proteolysis, plasminogen activation, ...
Component	apical part of cell, cell surface, ...
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (24 records)
Data Summary: Results (61)    Tissues (49)    Images (6)
Theiler Stages: 11, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	38
Northern blot	11
RT-PCR	12

cDNA source data(97)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(105) Genomic(2) cDNA(98) Primer pair(4) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000031538 (Evidence)
Entrez Gene	18791 (Evidence)
UniGene	154660
DFCI	TC1572057
DoTS	DT.101134740, DT.110885498, DT.490940, DT.94184788
NIA Mouse Gene Index	U009174
EC	3.4.21.68
Consensus CDS Project	CCDS22183.1
International Mouse Knockout Project Status	Plat

Sequences

Length	Strain/Species
genomic	ENSMUSG00000031538	Ensembl Gene Model | MGI Sequence Detail	25104	C57BL/6J
transcript	ENSMUST00000033941	Ensembl | MGI Sequence Detail	2531	Not Applicable
polypeptide	ENSMUSP00000033941	Ensembl | MGI Sequence Detail	559	Not Applicable

All sequences(30) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(8) : SNPs(287 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016060	Complement control module
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR000083	Fibronectin, type I
InterPro	IPR000001	Kringle
InterPro	IPR018056	Kringle, conserved site
InterPro	IPR013806	Kringle-like fold
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
InterPro	IPR026280	Tissue plasminogen activator
Protein Ontology	PR:000012825	tissue-type plasminogen activator

References

(Earliest) J:8866 Rajput B, et al., Chromosomal assignments of genes for tissue plasminogen activator and urokinase in mouse. Somat Cell Mol Genet. 1987 Sep;13(5):581-6
(Latest) J:190524 Shalom-Barak T, et al., Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
All references(238)

Other accession IDs

MGD-MRK-13346, MGI:1098659, MGI:2142697, MGI:2142776