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Plat
Gene Detail
 Symbol
Name
ID
Plat
plasminogen activator, tissue
MGI:97610
Synonyms D8Ertd2e, MGC:18508, tPA, t-PA
Feature Type protein coding gene
Genetic Map
Chromosome 8
11.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(38)
Sequence Map
Chr8:22757744-22782847 bp, + strand
From Ensembl annotation of GRCm38

  25104 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:717  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tissue plasminogen activator
Gene Tree: Plat

Human
homologs
Human Homolog PLAT, plasminogen activator, tissue
NCBI Gene ID 5327
neXtProt AC  NX_P00750
Human Synonyms  TPA, T-PA
Human Chr (Location)  8p12; chr8:42174718-42207676 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PLAT
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit abnormal behavior, CNS synpatic transmission, and response to injury.
 
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process negative regulation of proteolysis, plasminogen activation, ...
Component apical part of cell, cell surface, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (97)    Tissues (85)    Images (8)
Theiler Stages: 11, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 74
Northern blot 11
RT-PCR 12
cDNA source data(97)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(105) Genomic(2) cDNA(98) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000031538 (Evidence)
Entrez Gene18791 (Evidence)
UniGene154660
DFCITC1572057
DoTSDT.101134740, DT.110885498, DT.490940, DT.94184788
NIA Mouse Gene IndexU009174
EC3.4.21.68
Consensus CDS ProjectCCDS22183.1
International Mouse Knockout Project StatusPlat
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031538 Ensembl Gene Model | MGI Sequence Detail 25104 C57BL/6J ±  kb
transcript ENSMUST00000033941 Ensembl | MGI Sequence Detail 2531 Not Applicable 
polypeptide ENSMUSP00000033941 Ensembl | MGI Sequence Detail 559 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(1)
Polymorphisms RFLP(8) : SNPs within 2kb(338 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR000083 Fibronectin, type I
InterPro IPR000001 Kringle
InterPro IPR018056 Kringle, conserved site
InterPro IPR013806 Kringle-like fold
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR026280 Tissue plasminogen activator
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000012825 tissue-type plasminogen activator
References (Earliest) J:8866 Rajput B, et al., Chromosomal assignments of genes for tissue plasminogen activator and urokinase in mouse. Somat Cell Mol Genet. 1987 Sep;13(5):581-6
(Latest) J:207065 Berta T, et al., Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1beta and ERK signaling in the spinal cord of mice. Neuroscience. 2013 Sep 5;247:376-85
All references(245)
Other
accession IDs
MGD-MRK-13346, MGI:1098659, MGI:2142697, MGI:2142776

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory