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Plat
Gene Detail
Symbol

Name
ID
Plat
plasminogen activator, tissue
MGI:97610
Synonyms
D8Ertd2e, MGC:18508, tPA, t-PA
Feature Type
protein coding gene
Genetic Map
Chromosome 8
11.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(38)
Sequence Map
Chr8:22757744-22782847 bp, + strand
From Ensembl annotation of GRCm38

  25104 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:717  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PLAT
Protein SuperFamily: tissue plasminogen activator
Gene Tree: Plat

Human
homologs
PLAT, plasminogen activator, tissue
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5327
neXtProt AC: NX_P00750

Human Synonyms: TPA, T-PA

Human Chr (Location): 8p12; chr8:42174718-42207676 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PLAT

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit abnormal behavior, CNS synpatic transmission, and response to injury.
 
Interactions
Plat interacts with 132 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process negative regulation of proteolysis, plasminogen activation, ...
Component apical part of cell, cell surface, ...
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (97)    Tissues (85)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 74
Northern blot 11
RT-PCR 12
cDNA source data(97)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase plat    NEW 
Molecular
reagents
All nucleic(105) Genomic(2) cDNA(98) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000031538 (Evidence)
Entrez Gene 18791 (Evidence)
UniGene 154660
DFCI TC1572057
DoTS DT.101134740, DT.110885498, DT.490940, DT.94184788
NIA Mouse Gene Index U009174
EC 3.4.21.68
Consensus CDS Project CCDS22183.1
International Mouse Phenotyping Consortium Status Plat
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031538 Ensembl Gene Model | MGI Sequence Detail 25104 C57BL/6J ±  kb
transcript ENSMUST00000033941 Ensembl | MGI Sequence Detail 2531 Not Applicable 
polypeptide ENSMUSP00000033941 Ensembl | MGI Sequence Detail 559 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(8) : SNPs within 2kb(338 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 EGF-like domain
InterPro IPR000083 Fibronectin, type I
InterPro IPR000001 Kringle
InterPro IPR018056 Kringle, conserved site
InterPro IPR013806 Kringle-like fold
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR009003 Peptidase S1, PA clan
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR001254 Serine proteases, trypsin domain
InterPro IPR026280 Tissue plasminogen activator
Protein Ontology PR:000012825 tissue-type plasminogen activator
References
(Earliest) J:8866 Rajput B, et al., Chromosomal assignments of genes for tissue plasminogen activator and urokinase in mouse. Somat Cell Mol Genet. 1987 Sep;13(5):581-6
(Latest) J:222043 Hijazi N, et al., Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice. Blood. 2015 Apr 16;125(16):2558-67
All references(251)
Other
accession IDs
MGD-MRK-13346, MGI:1098659, MGI:2142697, MGI:2142776

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory