Serpinb2
Gene Detail

Symbol Name ID

Serpinb2 serine (or cysteine) peptidase inhibitor, clade B, member 2 MGI:97609

Synonyms

ovalbumin, PAI-2, Planh2

Feature Type

protein coding gene

Genetic Map

Chromosome 1

50.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:107511423-107535478 bp, + strand From VEGA annotation of GRCm38   24056 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20571  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog; 1 chicken

Protein SuperFamily: serpin
Gene Tree: Serpinb2

Human homologs

Human Homolog		SERPINB2, serpin peptidase inhibitor, clade B (ovalbumin), member 2
NCBI Gene ID		5055
neXtProt AC		NX_P05120
Human Synonyms		HsT1201, PAI, PAI2, PAI-2, PLANH2
Human Chr (Location)		18q21.3; chr18:61554939-61571124 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous inactivation of this gene leads to a slight to mild reduction in platelet, lymphocyte, neutrophil, and monocyte cell number.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	negative regulation of endopeptidase activity, negative regulation of peptidase activity, ...
Component	cytoplasm, extracellular region
Function	peptidase inhibitor activity, serine-type endopeptidase inhibitor activity

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (23)    Tissues (21)    Images (1)
Theiler Stages: 1, 2, 3, 4, 11, 13, 15, 17, 19, 20, 21, 22, 28

Assay Type	Results
RNA in situ	2
RT-PCR	21

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) Genomic(2) cDNA(15) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021001 (Evidence)
Ensembl Gene Model	ENSMUSG00000062345 (Evidence)
Entrez Gene	18788 (Evidence)
UniGene	271870
DFCI	TC1583425, TC1700163
DoTS	DT.101263878, DT.60105012
NIA Mouse Gene Index	U000690
Consensus CDS Project	CCDS15219.1
International Mouse Knockout Project Status	Serpinb2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021001	VEGA Gene Model | MGI Sequence Detail	24056	C57BL/6J
transcript	OTTMUST00000049648	VEGA | MGI Sequence Detail	1970	Not Applicable
polypeptide	OTTMUSP00000023037	VEGA | MGI Sequence Detail	415	Not Applicable

All sequences(52) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(100 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023795	Protease inhibitor I4, serpin, conserved site
InterPro	IPR015556	Protease inhibitor I4, serpin, plasminogen activator inhibitor-2
InterPro	IPR023796	Serpin domain
InterPro	IPR000215	Serpin family
Protein Ontology	PR:000030198	plasminogen activator inhibitor 2

References

(Earliest) J:32475 Belin D, et al., Facultative polypeptide translocation allows a single mRNA to encode the secreted and cytosolic forms of plasminogen activators inhibitor 2. EMBO J. 1989 Nov;8(11):3287-94
(Latest) J:179973 Delhase M, et al., TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. Proc Natl Acad Sci U S A. 2011 Dec 27;
All references(49)

Other accession IDs

MGD-MRK-13345