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Serpinb2
Gene Detail
 Symbol
Name
ID
Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
MGI:97609
Synonyms ovalbumin, PAI-2, Planh2
Feature Type protein coding gene
Genetic Map
Chromosome 1
50.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:107511423-107535478 bp, + strand
From VEGA annotation of GRCm38

  24056 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20571  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: serpin
Gene Tree: Serpinb2

Human
homologs
Human Homolog SERPINB2, serpin peptidase inhibitor, clade B (ovalbumin), member 2
NCBI Gene ID 5055
neXtProt AC  NX_P05120
Human Synonyms  HsT1201, PAI, PAI2, PAI-2, PLANH2
Human Chr (Location)  18q21.3; chr18:63887705-63903890 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to a slight to mild reduction in platelet, lymphocyte, neutrophil, and monocyte cell number.
 
Interactions
Serpinb2 interacts with 124 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process negative regulation of apoptotic process, negative regulation of endopeptidase activity, ...
Component cytoplasm, extracellular region, ...
Function peptidase inhibitor activity, serine-type endopeptidase inhibitor activity
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (20)    Tissues (18)    Images (1)
Theiler Stages: 1, 2, 3, 4, 11, 13, 15, 17, 19, 20, 21, 22, 28
Assay TypeResults
RNA in situ 2
RT-PCR 18
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(2) cDNA(15) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021001 (Evidence)
Ensembl Gene ModelENSMUSG00000062345 (Evidence)
Entrez Gene18788 (Evidence)
UniGene271870
DFCITC1583425, TC1700163
DoTSDT.101263878, DT.60105012
NIA Mouse Gene IndexU000690
Consensus CDS ProjectCCDS15219.1
International Mouse Knockout Project StatusSerpinb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021001 VEGA Gene Model | MGI Sequence Detail 24056 C57BL/6J ±  kb
transcript OTTMUST00000049648 VEGA | MGI Sequence Detail 1970 Not Applicable 
polypeptide OTTMUSP00000023037 VEGA | MGI Sequence Detail 415 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(245 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023795 Protease inhibitor I4, serpin, conserved site
InterPro IPR015556 Protease inhibitor I4, serpin, plasminogen activator inhibitor-2
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000030198 plasminogen activator inhibitor 2
References (Earliest) J:32475 Belin D, et al., Facultative polypeptide translocation allows a single mRNA to encode the secreted and cytosolic forms of plasminogen activators inhibitor 2. EMBO J. 1989 Nov;8(11):3287-94
(Latest) J:204777 Zhao A, et al., SerpinB2 is critical to Th2 immunity against enteric nematode infection. J Immunol. 2013 Jun 1;190(11):5779-87
All references(52)
Other
accession IDs
MGD-MRK-13345

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory