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Prkcz
Gene Detail
Symbol

Name
ID
Prkcz
protein kinase C, zeta
MGI:97602
Synonyms
aPKCzeta, Pkcz, zetaPKC
Feature Type
protein coding gene
Genetic Map
Chromosome 4
86.17 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:155260129-155361361 bp, - strand
From VEGA annotation of GRCm38

  101233 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55681  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRKCZ
Protein SuperFamily: protein kinase C, zeta/iota types
Gene Tree: Prkcz

Human
homologs
PRKCZ, protein kinase C, zeta
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5590
neXtProt AC: NX_Q05513

Human Synonyms: PKC2, PKC-ZETA

Human Chr (Location): 1p36.33-p36.2; chr1:2050470-2185395 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(13) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Young, not mature, homozygous null mice have reduced B cell numbers and abnormal secondary lymph organ structure. Young mice have fewer Peyer's patches, poor delineation of B & T cell zones, and fewer follicles of small size. Spleens have less prominent B cell follicles and abnormal marginal zones.
 
Interactions
Prkcz interacts with 265 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (95 annotations)
Process actin cytoskeleton reorganization, activation of phospholipase D activity, ...
Component apical cortex, apical plasma membrane, ...
Function 14-3-3 protein binding, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (71 records)
Data Summary: Results (366)    Tissues (256)    Images (95)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 13
RNA in situ 268
Western blot 22
RT-PCR 63
cDNA source data(63)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PRKCZ ; Xenbase prkcz ; ZFIN prkcz    NEW 
Molecular
reagents
All nucleic(72) Genomic(1) cDNA(63) Primer pair(8)
Microarray probesets(10)
Other database
links
VEGA Gene Model OTTMUSG00000010601 (Evidence)
Ensembl Gene Model ENSMUSG00000029053 (Evidence)
Entrez Gene 18762 (Evidence)
UniGene 28561
DFCI TC1575193, TC1586314, TC1597109, TC1652770, TC1714309, TC1749885
DoTS DT.101361174, DT.40133926, DT.40151057, DT.491666, DT.524169, DT.87050703, DT.94187405
NIA Mouse Gene Index U025868, U320986
EC 2.7.11.13
Consensus CDS Project CCDS19026.1, CCDS19027.1
International Mouse Phenotyping Consortium Status Prkcz
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010601 VEGA Gene Model | MGI Sequence Detail 101233 C57BL/6J ±  kb
transcript OTTMUST00000024756 VEGA | MGI Sequence Detail 2641 Not Applicable 
polypeptide OTTMUSP00000011362 VEGA | MGI Sequence Detail 592 Not Applicable 

For the selected sequences
All sequences(91) RefSeq(10) UniProt(9)
Polymorphisms
SNPs within 2kb(930 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR020454 Diacylglycerol/phorbol-ester binding
InterPro IPR000270 PB1 domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR012233 Protein kinase C
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
InterPro IPR017892 Protein kinase, C-terminal
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000013235 protein kinase C zeta type
References
(Earliest) J:10128 Wada H, et al., Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a. Biochem Biophys Res Commun. 1989 Nov 30;165(1):533-8
(Latest) J:221970 Witkowski MT, et al., Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia. Leukemia. 2015 Jun;29(6):1301-11
All references(169)
Other
accession IDs
MGD-MRK-13334, MGI:2140186, MGI:2140684, MGI:2140714

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory