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Gene Detail
protein kinase C, zeta
Synonyms aPKCzeta, Pkcz, zetaPKC
Feature Type protein coding gene
Genetic Map
Chromosome 4
86.17 cM, cytoband E2
Detailed Genetic Map ± 1 cM

Mapping data(4)
Sequence Map
Chr4:155260129-155361361 bp, - strand
From VEGA annotation of GRCm38

  101233 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:55681  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: protein kinase C, zeta/iota types
Gene Tree: Prkcz

Human Homolog PRKCZ, protein kinase C, zeta
NCBI Gene ID 5590
neXtProt AC  NX_Q05513
Human Synonyms  PKC2, PKC-ZETA
Human Chr (Location)  1p36.33-p36.2; chr1:2050470-2185395 (+)  GRCh38
alleles, and
All mutations/alleles(20) : Gene trapped(13) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
Young, not mature, homozygous null mice have reduced B cell numbers and abnormal secondary lymph organ structure. Young mice have fewer Peyer's patches, poor delineation of B & T cell zones, and fewer follicles of small size. Spleens have less prominent B cell follicles and abnormal marginal zones.
Prkcz interacts with 265 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
All GO classifications: (97 annotations)
Process actin cytoskeleton reorganization, activation of phospholipase D activity, ...
Component apical cortex, apical plasma membrane, ...
Function 14-3-3 protein binding, ATP binding, ...
External Resources: FuncBase
Literature Summary: (60 records)
Data Summary: Results (366)    Tissues (256)    Images (95)
Theiler Stages: 2, 3, 4, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 13
RNA in situ 268
Western blot 22
cDNA source data(63)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(72) Genomic(1) cDNA(63) Primer pair(8)
Microarray probesets(10)
Other database
VEGA Gene ModelOTTMUSG00000010601 (Evidence)
Ensembl Gene ModelENSMUSG00000029053 (Evidence)
Entrez Gene18762 (Evidence)
DFCITC1575193, TC1586314, TC1597109, TC1652770, TC1714309, TC1749885
DoTSDT.101361174, DT.40133926, DT.40151057, DT.491666, DT.524169, DT.87050703, DT.94187405
NIA Mouse Gene IndexU025868, U320986
Consensus CDS ProjectCCDS19026.1, CCDS19027.1
International Mouse Knockout Project StatusPrkcz
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010601 VEGA Gene Model | MGI Sequence Detail 101233 C57BL/6J ±  kb
transcript OTTMUST00000024756 VEGA | MGI Sequence Detail 2641 Not Applicable 
polypeptide OTTMUSP00000011362 VEGA | MGI Sequence Detail 592 Not Applicable 

For the selected sequences
All sequences(91) RefSeq(10) UniProt(9)
Polymorphisms SNPs within 2kb(930 from dbSNP Build 137)
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR020454 Diacylglycerol/phorbol-ester binding
InterPro IPR000270 Phox/Bem1p
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR017892 Protein kinase, C-terminal
InterPro IPR012233 Protein kinase C, zeta/iota
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000013235 protein kinase C zeta type
References (Earliest) J:10128 Wada H, et al., Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a. Biochem Biophys Res Commun. 1989 Nov 30;165(1):533-8
(Latest) J:209809 Diehl SA, et al., G proteins Galphai1/3 are critical targets for Bordetella pertussis toxin-induced vasoactive amine sensitization. Infect Immun. 2014 Feb;82(2):773-82
All references(159)
accession IDs
MGD-MRK-13334, MGI:2140186, MGI:2140684, MGI:2140714

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory