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Prkcz Gene Detail
Summary
  • Symbol
    Prkcz
  • Name
    protein kinase C, zeta
  • Synonyms
    aPKCzeta, Pkcz, zetaPKC
  • Feature Type
    protein coding gene
  • IDs
    MGI:97602
    NCBI Gene: 18762
Location & Maps
more
  • Sequence Map
    Chr4:155260129-155361361 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      101233 bp   ±  kb flank

  • Genome Browsers
Homology
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  • Human Ortholog
    PRKCZ, protein kinase C zeta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRKCZ, protein kinase C zeta
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PKC2, PKC-ZETA
  • Links
    NCBI Gene ID: 5590
    neXtProt AC: NX_Q05513

  • Chr Location
    1p36.33-p36.2; chr1:2050470-2185395 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 5 alleles in 5 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Gene trapped
    13
  • Targeted
    7
  • Incidental Mutations
Young, not mature, homozygous null mice have reduced B cell numbers and abnormal secondary lymph organ structure. Young mice have fewer Peyer's patches, poor delineation of B & T cell zones, and fewer follicles of small size. Spleens have less prominent B cell follicles and abnormal marginal zones.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010601 VEGA Gene Model | MGI Sequence Detail 101233 C57BL/6J ±  kb
transcript OTTMUST00000024756 VEGA | MGI Sequence Detail 2641 Not Applicable  
polypeptide OTTMUSP00000011362 VEGA | MGI Sequence Detail 592 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    930 from dbSNP Build 137
Protein
Information
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Molecular
Reagents
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  • All nucleic 72
    Genomic 1
    cDNA 63
    Primer pair 8

    Microarray probesets 10
Other
Accession IDs
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MGD-MRK-13334, MGI:2140186, MGI:2140684, MGI:2140714
References
more
  • Summaries
    All 173
    Developmental Gene Expression 74
    Gene Ontology 19
    Phenotypes 32
  • Earliest
    J:10128 Wada H, et al., Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a. Biochem Biophys Res Commun. 1989 Nov 30;165(1):533-8
  • Latest
    J:223384 Abdelhamed ZA, et al., The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway. Dis Model Mech. 2015 Jun;8(6):527-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory