About   Help   FAQ
Prkch
Gene Detail
Symbol

Name
ID
Prkch
protein kinase C, eta
MGI:97600
Synonyms
Pkch
Feature Type
protein coding gene
Genetic Map
Chromosome 12
30.81 cM, cytoband C3-D1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:73584797-73778185 bp, + strand
From VEGA annotation of GRCm38

  193389 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:84384  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRKCH
Protein SuperFamily: protein kinase C, delta/epsilon/eta/theta types
Gene Tree: Prkch

Human
homologs
PRKCH, protein kinase C, eta
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5583
neXtProt AC: NX_P24723

Human Synonyms: nPKC-eta, PKCL, PKC-L, PRKCL

Human Chr (Location): 14q23.1; chr14:61321443-61550980 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PRKCH

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in increased sensitivity to induced skin tumors, epidermal hyperplasia, and delayed wound healing.
 
Interactions
Prkch interacts with 180 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process cell differentiation, intracellular signal transduction, ...
Component cell-cell junction, cytoplasm, ...
Function ATP binding, calcium-independent protein kinase C activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (104)    Tissues (55)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 12
RT-PCR 92
cDNA source data(52)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PRKCH ; Xenbase prkch    NEW 
Molecular
reagents
All nucleic(56) Genomic(2) cDNA(53) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000029341 (Evidence)
Ensembl Gene Model ENSMUSG00000021108 (Evidence)
Entrez Gene 18755 (Evidence)
UniGene 341677
DFCI TC1577683
DoTS DT.101368989, DT.99853779
EC 2.7.11.13
Consensus CDS Project CCDS25976.1
International Mouse Phenotyping Consortium Status Prkch
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029341 VEGA Gene Model | MGI Sequence Detail 193389 C57BL/6J ±  kb
transcript OTTMUST00000072699 VEGA | MGI Sequence Detail 3545 Not Applicable 
polypeptide OTTMUSP00000037480 VEGA | MGI Sequence Detail 683 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(1452 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR020454 Diacylglycerol/phorbol-ester binding
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR014376 Protein kinase C, delta/epsilon/eta/theta types
InterPro IPR027431 Protein kinase C, eta
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR017892 Protein kinase, C-terminal
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000002343 protein kinase C eta type
References
(Earliest) J:14175 Osada S, et al., A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin. J Biol Chem. 1990 Dec 25;265(36):22434-40
(Latest) J:209959 Kong KF, et al., Protein kinase C-eta controls CTLA-4-mediated regulatory T cell function. Nat Immunol. 2014 May;15(5):465-72
All references(47)
Other
accession IDs
MGD-MRK-13332

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory