Prkch
Gene Detail

Symbol Name ID

Prkch protein kinase C, eta MGI:97600

Synonyms

Pkch

Feature Type

protein coding gene

Genetic Map

Chromosome 12

30.81 cM, cytoband C3-D1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr12:73584797-73778185 bp, + strand From VEGA annotation of GRCm38   193389 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:84384  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: protein kinase C, delta/epsilon/eta/theta types
Gene Tree: Prkch

Human homologs

Human Homolog		PRKCH, protein kinase C, eta
NCBI Gene ID		5583
neXtProt AC		NX_P24723
Human Synonyms		nPKC-eta, PKCL, PKC-L, PRKCL
Human Chr (Location)		14q23.1; chr14:61788515-62017698 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PRKCH

Alleles and phenotypes

All alleles(7) : Targeted(5) Gene trapped(2)
 

Homozygous mutation of this gene results in increased sensitivity to induced skin tumors, epidermal hyperplasia, and delayed wound healing.

 

Gene Ontology (GO) classifications

All GO classifications: (37 annotations)

Process	cell differentiation, intracellular signal transduction, ...
Component	cytoplasm, cytosol, ...
Function	ATP binding, calcium-independent protein kinase C activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (101)    Tissues (52)    Images (3)
Theiler Stages: 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Western blot	9
RT-PCR	92

cDNA source data(52)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(56) Genomic(2) cDNA(53) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000029341 (Evidence)
Ensembl Gene Model	ENSMUSG00000021108 (Evidence)
Entrez Gene	18755 (Evidence)
UniGene	341677
DFCI	TC1577683
DoTS	DT.101368989, DT.99853779
EC	2.7.11.13
Consensus CDS Project	CCDS25976.1
International Mouse Knockout Project Status	Prkch

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029341	VEGA Gene Model | MGI Sequence Detail	193389	C57BL/6J
transcript	OTTMUST00000072699	VEGA | MGI Sequence Detail	3545	Not Applicable
polypeptide	OTTMUSP00000037480	VEGA | MGI Sequence Detail	683	Not Applicable

All sequences(27) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(1061 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000961	AGC-kinase, C-terminal
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR008973	C2 calcium/lipid-binding domain, CaLB
InterPro	IPR018029	C2 membrane targeting protein
InterPro	IPR020454	Diacylglycerol/phorbol-ester binding
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR014376	Protein kinase C, delta/epsilon/eta/theta types
InterPro	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro	IPR017892	Protein kinase, C-terminal
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000002343	protein kinase C eta type

References

(Earliest) J:14175 Osada S, et al., A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin. J Biol Chem. 1990 Dec 25;265(36):22434-40
(Latest) J:186080 Fu G, et al., Protein kinase C eta is required for T cell activation and homeostatic proliferation. Sci Signal. 2011;4(202):ra84
All references(46)

Other accession IDs

MGD-MRK-13332