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Prkcd
Gene Detail
 Symbol
Name
ID
Prkcd
protein kinase C, delta
MGI:97598
Synonyms D14Ertd420e, Pkcd, PKC[d], PKCdelta
Feature Type protein coding gene
Genetic Map
Chromosome 14
18.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr14:30595358-30626210 bp, - strand
From VEGA annotation of GRCm38

  30853 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55963  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: protein kinase C, delta/epsilon/eta/theta types
Gene Tree: Prkcd

Human
homologs
Human Homolog PRKCD, protein kinase C, delta
NCBI Gene ID 5580
neXtProt AC  NX_Q05655
Human Synonyms  CVID9, MAY1, nPKC-delta, PKCD
Human Chr (Location)  3p21.31; chr3:53161207-53192717 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PRKCD
Alleles
and
phenotypes
All alleles(9) : Gene trapped(2) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit decreased neutrophil cell numbers and activity, increased B cell numbers and proliferation, increased acute inflammation, and increased IgG1 and IgA serum levels.
 
Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (72 annotations)
Process apoptotic process, aspartate transport, ...
Component cell-cell junction, cytoplasm, ...
Function ATP binding, calcium-independent protein kinase C activity, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (160)    Tissues (96)    Images (39)
Theiler Stages: 2, 3, 5, 19, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 69
Western blot 30
RT-PCR 57
cDNA source data(74)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(78) cDNA(75) Primer pair(3)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000025129 (Evidence)
Ensembl Gene ModelENSMUSG00000021948 (Evidence)
Entrez Gene18753 (Evidence)
UniGene2314
DFCITC1578909, TC1590684, TC1595933, TC1687695
DoTSDT.101129641, DT.101400708, DT.101402781, DT.110745188, DT.110745213, DT.110745221, DT.492188, DT.97414946
NIA Mouse Gene IndexU035358, U131879
EC2.7.10.2, 2.7.11.13
PDB1PTQ, 1PTR, 3UEJ, 3UEY, 3UFF, 3UGD, 3UGI, 3UGL
Consensus CDS ProjectCCDS26895.1
International Mouse Knockout Project StatusPrkcd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025129 VEGA Gene Model | MGI Sequence Detail 30853 C57BL/6J ±  kb
transcript OTTMUST00000061813 VEGA | MGI Sequence Detail 2612 Not Applicable 
polypeptide OTTMUSP00000030403 VEGA | MGI Sequence Detail 700 Not Applicable 

For the selected sequences
All sequences(101) RefSeq(10) UniProt(11)
Polymorphisms RFLP(3) : SNPs within 2kb(164 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR020454 Diacylglycerol/phorbol-ester binding
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR027436 Protein kinase C, delta
InterPro IPR014376 Protein kinase C, delta/epsilon/eta/theta types
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR017892 Protein kinase, C-terminal
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000002341 protein kinase C delta type
References (Earliest) J:2328 Mizuno K, et al., Structure and properties of a ubiquitously expressed protein kinase C, nPKC delta. Eur J Biochem. 1991 Dec 18;202(3):931-40
(Latest) J:209809 Diehl SA, et al., G proteins Galphai1/3 are critical targets for Bordetella pertussis toxin-induced vasoactive amine sensitization. Infect Immun. 2014 Feb;82(2):773-82
All references(175)
Other
accession IDs
MGD-MRK-13330, MGI:1196301, MGI:2145627

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory