Prkcd MGI Mouse Gene Detail - MGI:97598 - protein kinase C, delta

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Prkcd Gene Detail

Symbol

Prkcd
Name

protein kinase C, delta
Synonyms

D14Ertd420e, Pkcd, PKC[d], PKCdelta

Feature Type

protein coding gene
IDs

MGI:97598
NCBI Gene: 18753
Alliance

genome feature page
Transcription Start Sites

27 TSS

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Sequence Map

Chr14:30317311-30348167 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 18.82 cM
Mapping Data

9 experiments

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SNPs within 2kb

759 from dbSNP Build 142
Strain Annotations

19
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_97598	protein coding gene	Chr14:30317310-30348637 (-)
129S1/SvImJ	ENSMUSG00200037357	protein coding gene	Chr14:22138984-22169837 (-)
A/J	ENSMUSG00195012140	protein coding gene	Chr14:23216156-23247005 (-)
AKR/J	ENSMUSG00220031968	protein coding gene	Chr14:22328550-22359392 (-)
BALB/cJ	ENSMUSG00180025477	protein coding gene	Chr14:22304767-22335607 (-)
C3H/HeJ	ENSMUSG00175034160	protein coding gene	Chr14:22372045-22402892 (-)
C57BL/6NJ	ENSMUSG00215026375	protein coding gene	Chr14:22608727-22639589 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019052	protein coding gene	Chr14:22903704-22934171 (-)
CAST/EiJ	ENSTCUG00005023444	protein coding gene	Chr14:22445075-22476070 (-)
CBA/J	ENSMUSG00210033699	protein coding gene	Chr14:22615026-22645867 (-)
DBA/2J	ENSMUSG00185040459	protein coding gene	Chr14:26882746-26913604 (-)
FVB/NJ	ENSMUSG00205025151	protein coding gene	Chr14:22474054-22504887 (-)
JF1/MsJ	ENSUMUG00000031442	protein coding gene	Chr14:34139419-34170434 (-)
LP/J	ENSMUSG00230035693	protein coding gene	Chr14:34163010-34193866 (-)
NOD/ShiLtJ	ENSMUSG00190017675	protein coding gene	Chr14:22628615-22659448 (-)
NZO/HlLtJ	ENSMUSG00225037259	protein coding gene	Chr14:28503284-28534122 (-)
PWK/PhJ	ENSLUMG00010019782	protein coding gene	Chr14:10732068-10763170 (-)
SPRET/EiJ	ENSMSPG00010033395	protein coding gene	Chr14:24282899-24313483 (-)
WSB/EiJ	ENSIUOG00005012339	protein coding gene	Chr14:22433099-22464011 (-)

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Human Ortholog

PRKCD, protein kinase C delta

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRKCD, protein kinase C delta
Synonyms

ALPS3, CVID9, MAY1, nPKC-delta, PKCD
Links

HGNC:9399

NCBI Gene ID: 5580

UniProt: Q05655
Chr Location

3p21.1; chr3:53156009-53192717 (+) GRCh38

MGI Vertebrate Homology

Prkcd stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PRKCD
Protein SuperFamily

PKC_delta
Gene Tree

Prkcd

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Diseases

2 with human PRKCD associations

				Human Disease	Mouse Models
				autoimmune lymphoproliferative syndrome type 3 IDs autoimmune lymphoproliferative syndrome type 3 DOID:0110119 OMIM:615559
				steatotic liver disease IDs steatotic liver disease DOID:9452 DOID:9451 ICD10CM:K70.0 ICD9CM:571.0 MESH:D005234 MESH:D005235 NCI:C197833 OMIM:228100 UMLS_CUI:C0015695 UMLS_CUI:C0015696

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

45 phenotypes from 7 alleles in 8 genetic backgrounds
21 phenotypes from multigenic genotypes
1 images
117 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Chemically induced (ENU)

2
Endonuclease-mediated

10
Gene trapped

2
Targeted

12
Transgenic

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

53 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit decreased neutrophil cell numbers and activity, increased B cell numbers and proliferation, increased acute inflammation, and increased IgG1 and IgA serum levels.

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All GO Annotations

167
GO References

22

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

895
Tissues

176
cDNA Data

76
Literature Summary

31

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prkcd

ZFIN prkcda

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All Sequences

98
RefSeq

14
UniProt

15
CCDS

CCDS26895.1, CCDS79285.1

Ensembl

ENSMUSG00000021948 (Evidence)
NCBI Gene

18753

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000021948	Ensembl Gene Model \| MGI Sequence Detail	30857	C57BL/6J	± kb
	transcript	ENSMUST00000022521	Ensembl \| MGI Sequence Detail	2612	Not Applicable
	polypeptide	ENSMUSP00000022521	Ensembl \| MGI Sequence Detail	700	Not Applicable

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UniProt

15 Sequences
Protein Ontology

PR:000002341 protein kinase C delta type

(term hierarchy)
PDB

1PTQ, 1PTR, 3UEJ, 3UEY, 3UFF, 3UGD, 3UGI, 3UGL
EC

2.7.10.2, 2.7.11.1, 2.7.11.13
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR046349 C1-like domain superfamily

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR020454 Diacylglycerol/phorbol-ester binding

IPR017441 Protein kinase, ATP binding site

IPR027436 Protein kinase C, delta

IPR014376 Protein kinase C, delta/epsilon/eta/theta types

IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

IPR017892 Protein kinase, C-terminal

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

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All nucleic 81

cDNA 77

Primer pair 3

Other 1

Antibodies 7

Microarray probesets 6

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MGD-MRK-13330, MGI:1196301, MGI:2145627

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Summaries

All 309

Developmental Gene Expression 31

Gene Ontology 22

Phenotypes 117
Earliest

J:2328 Mizuno K, et al., Structure and properties of a ubiquitously expressed protein kinase C, nPKC delta. Eur J Biochem. 1991 Dec 18;202(3):931-40
Latest

J:371487 Tseng CS, et al., A developmental gradient of COUP-TFI expression regulates the relative size of hippocampus dorsal and ventral subregions. PLoS Biol. 2025 Aug;23(8):e3003355

TSS for Prkcd:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr127888	Chr14:30348367-30348384 (-)	-209 bp
Tssr127887	Chr14:30348153-30348177 (-)	2 bp
Tssr127886	Chr14:30347852-30347894 (-)	294 bp
Tssr127885	Chr14:30347407-30347439 (-)	744 bp
Tssr127884	Chr14:30347275-30347296 (-)	881 bp
Tssr127883	Chr14:30347100-30347115 (-)	1,059 bp
Tssr127882	Chr14:30347083-30347094 (-)	1,078 bp
Tssr127881	Chr14:30347052-30347062 (-)	1,110 bp
Tssr127880	Chr14:30346990-30347019 (-)	1,162 bp
Tssr127879	Chr14:30344118-30344125 (-)	4,045 bp
Tssr127878	Chr14:30340090-30340092 (-)	8,076 bp
Tssr127877	Chr14:30338808-30338818 (-)	9,354 bp
Tssr127876	Chr14:30331102-30331134 (-)	17,049 bp
Tssr127875	Chr14:30329780-30329781 (-)	18,386 bp
Tssr127874	Chr14:30329765-30329778 (-)	18,395 bp
Tssr127873	Chr14:30329736-30329761 (-)	18,418 bp
Tssr4363	Chr14:30329726-30329731 (-)	18,438 bp
Tssr127872	Chr14:30328654-30328670 (-)	19,505 bp
Tssr4362	Chr14:30327798-30327866 (-)	20,335 bp
Tssr127871	Chr14:30327123-30327132 (-)	21,039 bp
Tssr127870	Chr14:30326893-30326940 (-)	21,250 bp
Tssr127869	Chr14:30321443-30321457 (-)	26,717 bp
Tssr127868	Chr14:30321374-30321389 (-)	26,785 bp
Tssr127867	Chr14:30321321-30321340 (-)	26,836 bp
Tssr127866	Chr14:30318499-30318503 (-)	29,666 bp
Tssr127865	Chr14:30317705-30317739 (-)	30,445 bp
Tssr127864	Chr14:30317666-30317684 (-)	30,492 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24