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Prkcd Gene Detail
Summary
  • Symbol
    Prkcd
  • Name
    protein kinase C, delta
  • Synonyms
    D14Ertd420e, Pkcd, PKC[d], PKCdelta
  • Feature Type
    protein coding gene
  • IDs
    MGI:97598
    NCBI Gene: 18753
  • Gene Overview
    MyGene.info: PRKCD
Location & Maps
more
  • Sequence Map
    Chr14:30595358-30626210 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30853 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 18.82 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    PRKCD, protein kinase C delta
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PRKCD, protein kinase C delta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALPS3, CVID9, MAY1, nPKC-delta, PKCD
  • Links
    NCBI Gene ID: 5580
    neXtProt AC: NX_Q05655

  • Chr Location
    3p21.31; chr3:53161207-53192717 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PRKCD associations

Human Disease Mouse Models
       Autoimmune Lymphoproliferative Syndrome, Type III; ALPS3   OMIM: 615559
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    41 phenotypes from 5 alleles in 6 genetic backgrounds
    21 phenotypes from multigenic genotypes
    1 images
    70 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Gene trapped
    2
  • Targeted
    8
  • Transgenic
    1
  • Incidental Mutations
Mice homozygous for a null allele exhibit decreased neutrophil cell numbers and activity, increased B cell numbers and proliferation, increased acute inflammation, and increased IgG1 and IgA serum levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025129 VEGA Gene Model | MGI Sequence Detail 30853 C57BL/6J ±  kb
transcript OTTMUST00000061813 VEGA | MGI Sequence Detail 2612 Not Applicable  
polypeptide OTTMUSP00000030403 VEGA | MGI Sequence Detail 700 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    164 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 79
    cDNA 76
    Primer pair 3

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-13330, MGI:1196301, MGI:2145627
References
more
  • Summaries
    All 189
    Developmental Gene Expression 23
    Gene Ontology 15
    Phenotypes 70
  • Earliest
    J:2328 Mizuno K, et al., Structure and properties of a ubiquitously expressed protein kinase C, nPKC delta. Eur J Biochem. 1991 Dec 18;202(3):931-40
  • Latest
    J:230890 Shabrova E, et al., Retinol as a cofactor for PKCdelta-mediated impairment of insulin sensitivity in a mouse model of diet-induced obesity. FASEB J. 2016 Mar;30(3):1339-55

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory