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Prkacb Gene Detail
Summary
  • Symbol
    Prkacb
  • Name
    protein kinase, cAMP dependent, catalytic, beta
  • Synonyms
    cAMP-dependent protein kinase C beta, Pkacb
  • Feature Type
    protein coding gene
  • IDs
    MGI:97594
    NCBI Gene: 18749
  • Gene Overview
    MyGene.info: PRKACB
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:146729579-146812946 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 72.28 cM, cytoband H3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    503 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97594
protein coding gene Chr3:146729574-146812990 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027979
protein coding gene Chr3:150264697-150351041 (-)
A/J MGP_AJ_G0027938
protein coding gene Chr3:144862254-144946687 (-)
AKR/J MGP_AKRJ_G0027904
protein coding gene Chr3:148739838-148827749 (-)
BALB/cJ MGP_BALBcJ_G0027950
protein coding gene Chr3:144685193-144770788 (-)
C3H/HeJ MGP_C3HHeJ_G0027680
protein coding gene Chr3:149101237-149188941 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028393
protein coding gene Chr3:155301472-155392324 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025731
protein coding gene Chr3:139917727-139998494 (-)
CAST/EiJ MGP_CASTEiJ_G0027133
protein coding gene Chr3:149087613-149171895 (-)
CBA/J MGP_CBAJ_G0027655
protein coding gene Chr3:160807935-160897380 (-)
DBA/2J MGP_DBA2J_G0027795
protein coding gene Chr3:144017053-144101030 (-)
FVB/NJ MGP_FVBNJ_G0027762
protein coding gene Chr3:141427785-141510901 (-)
LP/J MGP_LPJ_G0027906
protein coding gene Chr3:151645117-151734348 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027795
protein coding gene Chr3:169076497-169161948 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028452
protein coding gene Chr3:148317001-148405175 (-)
PWK/PhJ MGP_PWKPhJ_G0026856
protein coding gene Chr3:143881812-143966227 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026684
protein coding gene Chr3:146479088-146618143 (-)
WSB/EiJ MGP_WSBEiJ_G0027213
protein coding gene Chr3:149303196-149391748 (-)



Homology
more
  • Human Ortholog
    PRKACB, protein kinase cAMP-activated catalytic subunit beta
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PRKACB, protein kinase cAMP-activated catalytic subunit beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PKACB, PKA C-beta
  • Links
    NCBI Gene ID: 5567
    neXtProt AC: NX_P22694
    UniProt: P22694

  • Chr Location
    1p31.1; chr1:84077975-84238498 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotypes from multigenic genotypes
    2 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation eliminating the Cbeta1 subunit exhibit impaired hippocampal plasticity, including failure of low frequency stimulation to produce lasting depression and the elimination of mossy fiber long term potentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18749 NCBI Gene Model | MGI Sequence Detail 83368 C57BL/6J ±  kb
    transcript NM_011100 RefSeq | MGI Sequence Detail 4341 C57BL/6  
    polypeptide P68181 UniProt | EBI | MGI Sequence Detail 351 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 235
      Genomic 6
      cDNA 226
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13325
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 7
      Phenotypes 20
    • Earliest
      J:35384 Uhler MD, et al., Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase [published erratum appears in J Biol Chem 1987 Apr 15;262(11):5431]. J Biol Chem. 1986 Nov 25;261(33):15360-3
    • Latest
      J:272374 Moen LV, et al., Ablation of the Cbeta2 subunit of PKA in immune cells leads to increased susceptibility to systemic inflammation in mice. Eur J Immunol. 2017 Nov;47(11):1880-1889

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    09/10/2019
    MGI 6.14
    The Jackson Laboratory