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Prkacb
Gene Detail
Symbol

Name
ID
Prkacb
protein kinase, cAMP dependent, catalytic, beta
MGI:97594
Synonyms
cAMP-dependent protein kinase C beta, Pkacb
Feature Type
protein coding gene
Genetic Map
Chromosome 3
72.28 cM, cytoband H3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:146729579-146812960 bp, - strand
From VEGA annotation of GRCm38

  83382 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:121718  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: PRKACB
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Prkacb

Human
homologs
PRKACB, protein kinase, cAMP-dependent, catalytic, beta
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5567
neXtProt AC: NX_P22694

Human Synonyms: PKACB, PKA C-beta

Human Chr (Location): 1p31.1; chr1:84077975-84238498 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(20) Targeted(4)
Genomic Mutations involving Prkacb (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation eliminating the Cbeta1 subunit exhibit impaired hippocampal plasticity, including failure of low frequency stimulation to produce lasting depression and the elimination of mossy fiber long term potentiation.
 
Phenotype Images(2)
Interactions
Prkacb interacts with 358 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Expression
Literature Summary: (6 records)
Data Summary: Results (144)    Tissues (141)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 50
cDNA source data(225)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase prkacb    NEW 
Molecular
reagents
All nucleic(234) Genomic(5) cDNA(226) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000016475 (Evidence)
Ensembl Gene Model ENSMUSG00000005034 (Evidence)
Entrez Gene 18749 (Evidence)
UniGene 16766
DFCI TC1579950, TC1614194, TC1638534, TC1641717
DoTS DT.101276761, DT.103567270, DT.111048569, DT.536371, DT.91360853, DT.91406819
NIA Mouse Gene Index U024745
EC 2.7.11.11
Consensus CDS Project CCDS17906.1, CCDS51090.1, CCDS51091.1, CCDS51092.1
International Mouse Phenotyping Consortium Status Prkacb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016475 VEGA Gene Model | MGI Sequence Detail 83382 C57BL/6J ±  kb
transcript OTTMUST00000039729 VEGA | MGI Sequence Detail 4001 Not Applicable 
polypeptide OTTMUSP00000017727 VEGA | MGI Sequence Detail 398 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(8) UniProt(6)
Polymorphisms
SNPs within 2kb(507 from dbSNP Build 137)    SNPs within 2kb including multiple locations(513)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000013223 cAMP-dependent protein kinase catalytic subunit beta
References
(Earliest) J:35384 Uhler MD, et al., Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase [published erratum appears in J Biol Chem 1987 Apr 15;262(11):5431]. J Biol Chem. 1986 Nov 25;261(33):15360-3
(Latest) J:191730 Garcia-Haro L, et al., Glucose-dependent regulation of AMP-activated protein kinase in MIN6 beta cells is not affected by the protein kinase A pathway. FEBS Lett. 2012 Nov 30;586(23):4241-7
All references(55)
Other
accession IDs
MGD-MRK-13325

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory