About   Help   FAQ
Prkacb Gene Detail
Summary
  • Symbol
    Prkacb
  • Name
    protein kinase, cAMP dependent, catalytic, beta
  • Synonyms
    cAMP-dependent protein kinase C beta, Pkacb
  • Feature Type
    protein coding gene
  • IDs
    MGI:97594
    NCBI Gene: 18749
  • Gene Overview
    MyGene.info: PRKACB
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:146729574-146812990 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      83417 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 72.28 cM, cytoband H3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PRKACB, protein kinase cAMP-activated catalytic subunit beta
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PRKACB, protein kinase cAMP-activated catalytic subunit beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PKACB, PKA C-beta
  • Links
    NCBI Gene ID: 5567
    neXtProt AC: NX_P22694
    UniProt: P22694

  • Chr Location
    1p31.1; chr1:84077975-84238498 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotypes from multigenic genotypes
    2 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation eliminating the Cbeta1 subunit exhibit impaired hippocampal plasticity, including failure of low frequency stimulation to produce lasting depression and the elimination of mossy fiber long term potentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016475 VEGA Gene Model | MGI Sequence Detail 83417 C57BL/6J ±  kb
    transcript OTTMUST00000039729 VEGA | MGI Sequence Detail 4001 Not Applicable  
    polypeptide OTTMUSP00000017727 VEGA | MGI Sequence Detail 398 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      503 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 235
      Genomic 6
      cDNA 226
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13325
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 6
      Phenotypes 19
    • Earliest
      J:35384 Uhler MD, et al., Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase [published erratum appears in J Biol Chem 1987 Apr 15;262(11):5431]. J Biol Chem. 1986 Nov 25;261(33):15360-3
    • Latest
      J:248981 Li J, et al., PKA-mediated Gli2 and Gli3 phosphorylation is inhibited by Hedgehog signaling in cilia and reduced in Talpid3 mutant. Dev Biol. 2017 Sep 1;429(1):147-157

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory