Prkacb
Gene Detail

Symbol Name ID

Prkacb protein kinase, cAMP dependent, catalytic, beta MGI:97594

Synonyms

cAMP-dependent protein kinase C beta, Pkacb

Feature Type

protein coding gene

Genetic Map

Chromosome 3

72.28 cM, cytoband H3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr3:146729579-146812960 bp, - strand From VEGA annotation of GRCm38   83382 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:121718  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Prkacb

Human homologs

Human Homolog		PRKACB, protein kinase, cAMP-dependent, catalytic, beta
NCBI Gene ID		5567
neXtProt AC		NX_P22694
Human Synonyms		PKACB
Human Chr (Location)		1p31.1; chr1:84543745-84704181 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(23) : Targeted(3) Gene trapped(20)
 

Homozygotes for a targeted null mutation eliminating the Cbeta1 subunit exhibit impaired hippocampal plasticity, including failure of low frequency stimulation to produce lasting depression and the elimination of mossy fiber long term potentiation.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	adenylate cyclase-modulating G-protein coupled receptor signaling pathway, negative regulation of meiotic cell cycle, ...
Component	cAMP-dependent protein kinase complex, centrosome, ...
Function	ATP binding, cAMP-dependent protein kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (144)    Tissues (140)    Images (10)
Theiler Stages: 22, 23, 26, 28

Assay Type	Results
RNA in situ	94
RT-PCR	50

cDNA source data(201)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(210) Genomic(5) cDNA(202) Primer pair(3)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000016475 (Evidence)
Ensembl Gene Model	ENSMUSG00000005034 (Evidence)
Entrez Gene	18749 (Evidence)
UniGene	16766
DFCI	TC1579950, TC1614194, TC1638534, TC1641717
DoTS	DT.101276761, DT.103567270, DT.111048569, DT.536371, DT.91360853, DT.91406819
NIA Mouse Gene Index	U024745
EC	2.7.11.11
Consensus CDS Project	CCDS17906.1, CCDS51090.1, CCDS51091.1, CCDS51092.1
International Mouse Knockout Project Status	Prkacb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016475	VEGA Gene Model | MGI Sequence Detail	83382	C57BL/6J
transcript	OTTMUST00000039729	VEGA | MGI Sequence Detail	4001	Not Applicable
polypeptide	OTTMUSP00000017727	VEGA | MGI Sequence Detail	398	Not Applicable

All sequences(73) RefSeq(8) UniProt(5)

Polymorphisms

SNPs(471 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000961	AGC-kinase, C-terminal
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000013223	cAMP-dependent protein kinase catalytic subunit beta

References

(Earliest) J:35384 Uhler MD, et al., Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase [published erratum appears in J Biol Chem 1987 Apr 15;262(11):5431]. J Biol Chem. 1986 Nov 25;261(33):15360-3
(Latest) J:191730 Garcia-Haro L, et al., Glucose-dependent regulation of AMP-activated protein kinase in MIN6 beta cells is not affected by the protein kinase A pathway. FEBS Lett. 2012 Nov 30;586(23):4241-7
All references(57)

Other accession IDs

MGD-MRK-13325