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Pkm Gene Detail
Summary
  • Symbol
    Pkm
  • Name
    pyruvate kinase, muscle
  • Synonyms
    Pk-2, Pk3, Pk-3, Pkm2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97591
    NCBI Gene: 18746
  • Gene Overview
    MyGene.info: PKM
Location & Maps
more
  • Sequence Map
    Chr9:59656368-59679375 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23008 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 32.03 cM
  • Mapping Data
    14 experiments
Homology
more
  • Human Ortholog
    PKM, pyruvate kinase, muscle
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PKM, pyruvate kinase, muscle
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CTHBP, HEL-S-30, OIP3, PK3, PKM2, TCB, THBP1
  • Links
    NCBI Gene ID: 5315
    neXtProt AC: NX_P14618

  • Chr Location
    15q22; chr15:72199029-72231812 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous allele exhibit prenatal lethality around the time of implanatation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18746 NCBI Gene Model | MGI Sequence Detail 23008 C57BL/6J ±  kb
transcript NM_001253883 RefSeq | MGI Sequence Detail 2432 Not Specified  
polypeptide P52480 UniProt | EBI | MGI Sequence Detail 531 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    170 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 39
    cDNA 33
    Primer pair 6

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-13319, MGD-MRK-13320, MGD-MRK-13322, MGI:2143183, MGI:2143184, MGI:2144733
References
more
  • Summaries
    All 78
    Developmental Gene Expression 14
    Gene Ontology 14
    Phenotypes 17
  • Earliest
    J:5994 Lalley PA, et al., Conservation of autosomal gene synteny groups in mouse and man. Nature. 1978 Jul 13;274(5667):160-3
  • Latest
    J:232562 Dayton TL, et al., Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma. Genes Dev. 2016 May 1;30(9):1020-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory