Pim1 MGI Mouse Gene Detail - MGI:97584 - proviral integration site 1

Pim1 Gene Detail

Symbol

Pim1
Name

proviral integration site 1
Synonyms

Pim-1

Feature Type

protein coding gene
IDs

MGI:97584
NCBI Gene: 18712
Gene Overview

MyGene.info: PIM1

Sequence Map

Chr17:29490812-29496111 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

5300 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 15.38 cM
Mapping Data

82 experiments
Sequence Tags

D17Mit23, D17Mit30, D17Mit60, D17Mit61, D17Mit81

Human Ortholog

PIM1, Pim-1 proto-oncogene, serine/threonine kinase

Vertebrate Orthologs

10

Human Ortholog

PIM1, Pim-1 proto-oncogene, serine/threonine kinase
Orthology source: HomoloGene, HGNC
Synonyms

PIM
Links

HGNC:8986

NCBI Gene ID: 5292

neXtProt AC: NX_P11309

UniProt: P11309
Chr Location

6p21.2; chr6:37170146-37175428 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 11214
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: PIM1
Protein SuperFamily

proto-oncogene serine/threonine-protein kinase Pim-1
Gene Tree

Pim1

less

Phenotype Summary

11 phenotypes from 4 alleles in 3 genetic backgrounds
14 phenotypes from multigenic genotypes
45 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Gene trapped

7
Targeted

5
Transgenic

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

9 strains or lines available

Mice homozygous for disruptions in this gene have abnormally small erythrocytes but are otherwise phenotypically normal.

less

All GO Annotations

30
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

39
Tissues

20
cDNA Data

10
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pim1

ZFIN pim1

less

Pim1 interacts with 161 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

less

All Sequences

21
RefSeq

2
UniProt

4
CCDS

CCDS79520.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000046297	VEGA Gene Model \| MGI Sequence Detail	5300	C57BL/6J	± kb
transcript	OTTMUST00000120691	VEGA \| MGI Sequence Detail	2638	Not Applicable
polypeptide	OTTMUSP00000066746	VEGA \| MGI Sequence Detail	313	Not Applicable

less

SNPs within 2kb

30 from dbSNP Build 142

PCR

1
RFLP

14

less

UniProt

4 Sequences
Protein Ontology

PR:000012732 proto-oncogene serine/threonine-protein kinase Pim-1

(term hierarchy)
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain

IPR008271 Serine/threonine-protein kinase, active site

IPR017348 Serine/threonine-protein kinase pim-1/2/3

less

All nucleic 34

Genomic 17

cDNA 11

Primer pair 2

Other 4

Microarray probesets 3

less

MGD-MRK-13306, MGD-MRK-13310

Summaries

All 160

Developmental Gene Expression 8

Gene Ontology 5

Phenotypes 45
Earliest

J:7438 Cuypers HT, et al., Murine leukemia virus-induced T-cell lymphomagenesis: integration of proviruses in a distinct chromosomal region. Cell. 1984 May;37(1):141-50
Latest

J:234793 Uras IZ, et al., Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6. Blood. 2016 Jun 9;127(23):2890-902

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 07/11/2017 MGI 6.10