Pim1 MGI Mouse Gene Detail - MGI:97584 - proviral integration site 1

Symbol

Pim1
Name

proviral integration site 1
Synonyms

Pim-1

Feature Type

protein coding gene
IDs

MGI:97584
NCBI Gene: 18712
Gene Overview

MyGene.info: PIM1
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr17:29490785-29496111 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 15.38 cM
Mapping Data

82 experiments
Sequence Tags

D17Mit23, D17Mit30, D17Mit60, D17Mit61, D17Mit81

SNPs within 2kb

30 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

14

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97584	protein coding gene	Chr17:29490753-29496112 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023465	protein coding gene	Chr17:29030620-29036855 (+)
A/J	MGP_AJ_G0023423	protein coding gene	Chr17:28053598-28058549 (+)
AKR/J	MGP_AKRJ_G0023388	protein coding gene	Chr17:28280488-28285778 (+)
BALB/cJ	MGP_BALBcJ_G0023428	protein coding gene	Chr17:28293155-28299613 (+)
C3H/HeJ	MGP_C3HHeJ_G0023189	protein coding gene	Chr17:28656527-28661811 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023870	protein coding gene	Chr17:30168767-30175969 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021345	protein coding gene	Chr17:25354925-25360171 (+)
CAST/EiJ	MGP_CASTEiJ_G0022690	protein coding gene	Chr17:28639315-28642952 (+)
CBA/J	MGP_CBAJ_G0023164	protein coding gene	Chr17:31322085-31327032 (+)
DBA/2J	MGP_DBA2J_G0023294	protein coding gene	Chr17:27558039-27563318 (+)
FVB/NJ	MGP_FVBNJ_G0023264	protein coding gene	Chr17:27394377-27399884 (+)
LP/J	MGP_LPJ_G0023372	protein coding gene	Chr17:29286692-29292832 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023282	protein coding gene	Chr17:30637468-30643972 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023912	protein coding gene	Chr17:28735184-28740581 (+)
PWK/PhJ	MGP_PWKPhJ_G0022440	protein coding gene	Chr17:26399284-26404630 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022258	protein coding gene	Chr17:26722064-26727218 (+)
WSB/EiJ	MGP_WSBEiJ_G0022752	protein coding gene	Chr17:28699783-28706296 (+)

Human Ortholog

PIM1, Pim-1 proto-oncogene, serine/threonine kinase

Vertebrate Orthologs

10

Human Ortholog

PIM1, Pim-1 proto-oncogene, serine/threonine kinase
Orthology source: HomoloGene, HGNC
Synonyms

PIM
Links

HGNC:8986

NCBI Gene ID: 5292

neXtProt AC: NX_P11309

UniProt: P11309
Chr Location

6p21.2; chr6:37170146-37175428 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 11214
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: PIM1
Protein SuperFamily

proto-oncogene serine/threonine-protein kinase Pim-1
Gene Tree

Pim1

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Phenotype Summary

11 phenotypes from 4 alleles in 3 genetic backgrounds
14 phenotypes from multigenic genotypes
51 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Gene trapped

7
Targeted

5
Transgenic

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene have abnormally small erythrocytes but are otherwise phenotypically normal.

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All GO Annotations

43
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

670
Tissues

20
cDNA Data

11
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pim1

ZFIN pim1

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Pim1 interacts with 161 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

49
RefSeq

4
UniProt

5
CCDS

CCDS79520.1, CCDS89050.1

Ensembl

ENSMUSG00000024014 (Evidence)
NCBI Gene

18712

			Length	Strain/Species	Flank
genomic	18712	NCBI Gene Model \| MGI Sequence Detail	5327	C57BL/6J	± kb
transcript	NM_008842	RefSeq \| MGI Sequence Detail	2665	C57BL/6
polypeptide	P06803	UniProt \| EBI \| MGI Sequence Detail	313	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000012732 proto-oncogene serine/threonine-protein kinase Pim-1

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR017348 Serine/threonine-protein kinase pim-1/2/3

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All nucleic 36

Genomic 18

cDNA 12

Primer pair 2

Other 4

Microarray probesets 3

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MGD-MRK-13306, MGD-MRK-13310

Summaries

All 176

Developmental Gene Expression 9

Gene Ontology 8

Phenotypes 51
Earliest

J:7438 Cuypers HT, et al., Murine leukemia virus-induced T-cell lymphomagenesis: integration of proviruses in a distinct chromosomal region. Cell. 1984 May;37(1):141-50
Latest

J:298150 Zhang X, et al., Inhibition of PIM1 kinase attenuates bleomycin-induced pulmonary fibrosis in mice by modulating the ZEB1/E-cadherin pathway in alveolar epithelial cells. Mol Immunol. 2020 Sep;125:15-22

TSS for Pim1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143557	Chr17:29490468-29490475 (+)	-313 bp
Tssr143558	Chr17:29490606-29490616 (+)	-174 bp
Tssr143559	Chr17:29490637-29490655 (+)	-139 bp
Tssr143560	Chr17:29490688-29490700 (+)	-91 bp
Tssr143561	Chr17:29490752-29490767 (+)	-25 bp
Tssr143562	Chr17:29490775-29490799 (+)	2 bp
Tssr143563	Chr17:29490823-29490839 (+)	46 bp
Tssr143564	Chr17:29490846-29490862 (+)	69 bp
Tssr143565	Chr17:29490904-29490915 (+)	125 bp
Tssr143566	Chr17:29491343-29491357 (+)	565 bp
Tssr143567	Chr17:29491642-29491673 (+)	873 bp
Tssr143568	Chr17:29491725-29491738 (+)	947 bp
Tssr143569	Chr17:29491787-29491798 (+)	1,008 bp
Tssr143570	Chr17:29491800-29491805 (+)	1,018 bp
Tssr143571	Chr17:29492997-29493009 (+)	2,218 bp
Tssr143572	Chr17:29493037-29493105 (+)	2,286 bp
Tssr143573	Chr17:29493114-29493128 (+)	2,336 bp
Tssr143574	Chr17:29493132-29493143 (+)	2,353 bp
Tssr143575	Chr17:29493169-29493183 (+)	2,391 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 02/23/2021 MGI 6.16