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Pim1 Gene Detail
Summary
  • Symbol
    Pim1
  • Name
    proviral integration site 1
  • Synonyms
    Pim-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97584
    NCBI Gene: 18712
  • Gene Overview
    MyGene.info: PIM1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr17:29490812-29496111 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      5300 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 15.38 cM
  • Mapping Data
    82 experiments
  • Sequence Tags
    D17Mit23, D17Mit30, D17Mit60, D17Mit61, D17Mit81
Homology
more
  • Human Ortholog
    PIM1, Pim-1 proto-oncogene, serine/threonine kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PIM1, Pim-1 proto-oncogene, serine/threonine kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PIM
  • Links
    NCBI Gene ID: 5292
    neXtProt AC: NX_P11309
    UniProt: P11309

  • Chr Location
    6p21.2; chr6:37170146-37175428 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 4 alleles in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have abnormally small erythrocytes but are otherwise phenotypically normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    28
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    39
  • Tissues
    20
  • cDNA Data
    11
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000046297 VEGA Gene Model | MGI Sequence Detail 5300 C57BL/6J ±  kb
    transcript OTTMUST00000120691 VEGA | MGI Sequence Detail 2638 Not Applicable  
    polypeptide OTTMUSP00000066746 VEGA | MGI Sequence Detail 313 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      30 from dbSNP Build 142
    • PCR
      1
    • RFLP
      14
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 18
      cDNA 12
      Primer pair 2
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13306, MGD-MRK-13310
    References
    more
    • Summaries
      All 171
      Developmental Gene Expression 9
      Gene Ontology 5
      Phenotypes 48
    • Earliest
      J:7438 Cuypers HT, et al., Murine leukemia virus-induced T-cell lymphomagenesis: integration of proviruses in a distinct chromosomal region. Cell. 1984 May;37(1):141-50
    • Latest
      J:265434 Daenthanasanmak A, et al., PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity. J Clin Invest. 2018 Jul 2;128(7):2787-2801
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/09/2018
    MGI 6.12     		The Jackson Laboratory