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Pim1 Gene Detail
Summary
  • Symbol
    Pim1
  • Name
    proviral integration site 1
  • Synonyms
    Pim-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97584
    NCBI Gene: 18712
  • Gene Overview
    MyGene.info: PIM1
Location & Maps
more
  • Sequence Map
    Chr17:29490812-29496111 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      5300 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 15.38 cM
  • Mapping Data
    82 experiments
  • Sequence Tags
    D17Mit23, D17Mit30, D17Mit60, D17Mit61, D17Mit81
Homology
more
  • Human Ortholog
    PIM1, Pim-1 proto-oncogene, serine/threonine kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PIM1, Pim-1 proto-oncogene, serine/threonine kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PIM
  • Links
    NCBI Gene ID: 5292
    neXtProt AC: NX_P11309

  • Chr Location
    6p21.2; chr6:37170146-37175428 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 4 alleles in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Gene trapped
    7
  • Targeted
    5
  • Transgenic
    2
  • Incidental Mutations
    Mutagenetix , APF
Mice homozygous for disruptions in this gene have abnormally small erythrocytes but are otherwise phenotypically normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    24
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    39
  • Tissues
    20
  • cDNA Data
    10
  • Literature Summary
    8
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046297 VEGA Gene Model | MGI Sequence Detail 5300 C57BL/6J ±  kb
transcript OTTMUST00000120691 VEGA | MGI Sequence Detail 2638 Not Applicable  
polypeptide OTTMUSP00000066746 VEGA | MGI Sequence Detail 313 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    30 from dbSNP Build 142
  • PCR
    1
  • RFLP
    14
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000012732 proto-oncogene serine/threonine-protein kinase Pim-1
  • InterPro Domains
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
    IPR017348 Serine/threonine-protein kinase pim-1/2/3
Molecular
Reagents
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  • All nucleic 34
    Genomic 17
    cDNA 11
    Primer pair 2
    Other 4

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13306, MGD-MRK-13310
References
more
  • Summaries
    All 145
    Developmental Gene Expression 8
    Gene Ontology 5
    Phenotypes 45
  • Earliest
    J:7438 Cuypers HT, et al., Murine leukemia virus-induced T-cell lymphomagenesis: integration of proviruses in a distinct chromosomal region. Cell. 1984 May;37(1):141-50
  • Latest
    J:223691 Cen B, et al., The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling. Mol Cell Biol. 2014 Jul;34(13):2517-32
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory