Phb
Gene Detail

Symbol Name ID

Phb prohibitin MGI:97572

Feature Type

protein coding gene

Genetic Map

Chromosome 11

59.01 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:95666957-95680773 bp, + strand From VEGA annotation of GRCm38   13817 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Phb ± 2 cM)

Gene Tree: Phb

Human ortholog

PHB prohibitin NCBI Gene ID 5245
Human Synonyms: PHB1
Human Chr17:47481420-47492242 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human PHB (1)

Alleles and phenotypes

All alleles(20) : Targeted(8) Gene trapped(12)
 

Mice homozygous for a gene trapped allele exhibit early embryonic lethality while heterozygotes exhibit altered mammary gland development.

 

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	cellular response to interleukin-6, DNA biosynthetic process, ...
Component	cytoplasm, extrinsic to mitochondrial outer membrane, ...
Function	histone deacetylase binding, sequence-specific DNA binding RNA polymerase II transcription factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (12)    Tissues (3)   
Theiler Stages: 9

Assay Type	Results
Immunohistochemistry	9
In situ reporter (knock in)	3

cDNA source data(168)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(170) Genomic(1) cDNA(168) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000001749 (Evidence)
Ensembl Gene Model	ENSMUSG00000038845 (Evidence)
Entrez Gene	18673 (Evidence)
UniGene	263862
DFCI	TC1573277
Consensus CDS Project	CCDS25280.1
International Mouse Knockout Project Status	Phb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001749	VEGA Gene Model | MGI Sequence Detail	13817	C57BL/6J
transcript	OTTMUST00000003483	VEGA | MGI Sequence Detail	1799	Not Applicable
polypeptide	OTTMUSP00000001681	VEGA | MGI Sequence Detail	272	Not Applicable

All sequences(45) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(90 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001107	Band 7 protein
InterPro	IPR000163	Prohibitin
Protein Ontology	PR:000012631	prohibitin

References

(Earliest) J:3097 White JJ, et al., Assignment of the human prohibitin gene (PHB) to chromosome 17 and identification of a DNA polymorphism [published erratum appears in Genomics 1991 Nov;11(3):782]. Genomics. 1991 Sep;11(1):228-30
(Latest) J:191189 Lucas CR, et al., Prohibitins and the Cytoplasmic Domain of CD86 Cooperate To Mediate CD86 Signaling in B Lymphocytes. J Immunol. 2013 Jan 15;190(2):723-36
All references(52)

Other accession IDs

MGD-MRK-13290