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Phb
Gene Detail
Symbol

Name
ID
Phb
prohibitin
MGI:97572
Feature Type
protein coding gene
Genetic Map
Chromosome 11
59.01 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:95666957-95680773 bp, + strand
From VEGA annotation of GRCm38

  13817 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1980  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PHB
Gene Tree: Phb

Human
homologs
PHB, prohibitin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5245
neXtProt AC: NX_P35232

Human Synonyms: HEL-215, HEL-S-54e, PHB1

Human Chr (Location): 17q21; chr17:49404048-49414905 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PHB

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(8) Targeted(10)
Genomic Mutations involving Phb (2)
 
Mice homozygous for a gene trapped allele exhibit early embryonic lethality while heterozygotes exhibit altered mammary gland development.
 
Interactions
Phb interacts with 148 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (53 annotations)
Process cellular response to interleukin-6, DNA biosynthetic process, ...
Component cell surface, cytoplasm, ...
Function complement component C3a binding, complement component C3b binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (12)    Tissues (3)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 9
In situ reporter (knock in) 3
cDNA source data(168)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase phb ; ZFIN phb    NEW 
Molecular
reagents
All nucleic(170) Genomic(1) cDNA(168) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000001749 (Evidence)
Ensembl Gene Model ENSMUSG00000038845 (Evidence)
Entrez Gene 18673 (Evidence)
UniGene 263862
DFCI TC1573277
Consensus CDS Project CCDS25280.1
International Mouse Phenotyping Consortium Status Phb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001749 VEGA Gene Model | MGI Sequence Detail 13817 C57BL/6J ±  kb
transcript OTTMUST00000003483 VEGA | MGI Sequence Detail 1799 Not Applicable 
polypeptide OTTMUSP00000001681 VEGA | MGI Sequence Detail 272 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(149 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001107 Band 7 protein
InterPro IPR000163 Prohibitin
Protein Ontology PR:000012631 prohibitin
References
(Earliest) J:3097 White JJ, et al., Assignment of the human prohibitin gene (PHB) to chromosome 17 and identification of a DNA polymorphism [published erratum appears in Genomics 1991 Nov;11(3):782]. Genomics. 1991 Sep;11(1):228-30
(Latest) J:211408 Savulescu D, et al., Gonadotropin-releasing hormone-regulated prohibitin mediates apoptosis of the gonadotrope cells. Mol Endocrinol. 2013 Nov;27(11):1856-70
All references(49)
Other
accession IDs
MGD-MRK-13290

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory