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Phb Gene Detail
Summary
  • Symbol
    Phb
  • Name
    prohibitin
  • Feature Type
    protein coding gene
  • IDs
    MGI:97572
    NCBI Gene: 18673
  • Gene Overview
    MyGene.info: PHB
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr11:95666957-95680773 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 59.01 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    149 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97572
protein coding gene Chr11:95666957-95680773 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018986
protein coding gene Chr11:97879296-97898120 (+)
A/J MGP_AJ_G0018954
protein coding gene Chr11:93934185-93950435 (+)
AKR/J MGP_AKRJ_G0018924
protein coding gene Chr11:96837788-96853493 (+)
BALB/cJ MGP_BALBcJ_G0018927
protein coding gene Chr11:94414310-94429240 (+)
C3H/HeJ MGP_C3HHeJ_G0018741
protein coding gene Chr11:96962514-96979360 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019379
protein coding gene Chr11:100954387-100972683 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017010
protein coding gene Chr11:91416715-91428169 (+)
CAST/EiJ MGP_CASTEiJ_G0018295
protein coding gene Chr11:97777278-97791275 (+)
CBA/J MGP_CBAJ_G0018712
protein coding gene Chr11:105080579-105099736 (+)
DBA/2J MGP_DBA2J_G0018820
protein coding gene Chr11:93503982-93519500 (+)
FVB/NJ MGP_FVBNJ_G0018809
protein coding gene Chr11:92976758-92995391 (+)
LP/J MGP_LPJ_G0018890
protein coding gene Chr11:98452214-98466025 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018836
protein coding gene Chr11:105108808-105127558 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019419
protein coding gene Chr11:97111182-97130973 (+)
PWK/PhJ MGP_PWKPhJ_G0018066
protein coding gene Chr11:94443137-94457734 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017855
protein coding gene Chr11:96798862-96820944 (+)
WSB/EiJ MGP_WSBEiJ_G0018344
protein coding gene Chr11:97026248-97046112 (+)



Homology
more
  • Human Ortholog
    PHB, prohibitin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PHB, prohibitin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HEL-215, HEL-S-54e, PHB1
  • Links
    NCBI Gene ID: 5245
    neXtProt AC: NX_P35232
    UniProt: P35232

  • Chr Location
    17q21.33; chr17:49404048-49414905 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1980
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PHB
  • Gene Tree
    Phb
Human Diseases
more
  • Diseases
    1 with human PHB associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 6 alleles in 3 genetic backgrounds
    41 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit early embryonic lethality while heterozygotes exhibit altered mammary gland development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18673 NCBI Gene Model | MGI Sequence Detail 13817 C57BL/6J ±  kb
    transcript NM_008831 RefSeq | MGI Sequence Detail 1815 C57BL/6  
    polypeptide P67778 UniProt | EBI | MGI Sequence Detail 272 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 171
      Genomic 1
      cDNA 169
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13290
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 4
      Diseases 2
      Gene Ontology 13
      Phenotypes 21
    • Earliest
      J:3097 White JJ, et al., Assignment of the human prohibitin gene (PHB) to chromosome 17 and identification of a DNA polymorphism [published erratum appears in Genomics 1991 Nov;11(3):782]. Genomics. 1991 Sep;11(1):228-30
    • Latest
      J:242981 Ande SR, et al., Prohibitin-induced obesity leads to anovulation and polycystic ovary in mice. Biol Open. 2017 Jun 15;6(6):825-831

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory