About   Help   FAQ
Pgm3 Gene Detail
Summary
  • Symbol
    Pgm3
  • Name
    phosphoglucomutase 3
  • Synonyms
    2810473H05Rik, GlcNAc-P mutase, Pgm-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:97566
    NCBI Gene: 109785
  • Gene Overview
    MyGene.info: PGM3
Location & Maps
more
  • Sequence Map
    Chr9:86554377-86571842 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17466 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 46.58 cM, cytoband E3.2
  • Mapping Data
    24 experiments
Homology
more
  • Human Ortholog
    PGM3, phosphoglucomutase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PGM3, phosphoglucomutase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AGM1, IMD23, PAGM, PGM 3
  • Links
    NCBI Gene ID: 5238
    neXtProt AC: NX_O95394

  • Chr Location
    6q14.1-q15; chr6:83151972-83193936 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PGM3 associations

Human Disease Mouse Models
       Immunodeficiency 23; IMD23   OMIM: 615816
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Genomic Mutations
    1 involving Pgm3
  • Incidental Mutations
Mice homozygous for a hypomorphic allele exhibit male infertility, anemia, leukopenia, thrombocytopenia, abnormal pancreatic and salivary gland morphology, and splenomegaly.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045044 VEGA Gene Model | MGI Sequence Detail 17466 C57BL/6J ±  kb
transcript OTTMUST00000118375 VEGA | MGI Sequence Detail 2666 Not Applicable  
polypeptide OTTMUSP00000066077 VEGA | MGI Sequence Detail 542 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    127 from dbSNP Build 142
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000012617 phosphoacetylglucosamine mutase
  • PDB
  • EC
  • InterPro Domains
    IPR005844 Alpha-D-phosphohexomutase, alpha/beta/alpha domain I
    IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III
    IPR016066 Alpha-D-phosphohexomutase, conserved site
    IPR005843 Alpha-D-phosphohexomutase, C-terminal
    IPR016657 Phosphoacetylglucosamine mutase
Molecular
Reagents
less
  • All nucleic 21
    cDNA 19
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-13277, MGD-MRK-13280, MGI:1920033, MGI:2143369, MGI:2143392
References
more
  • Summaries
    All 53
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 6
  • Earliest
    J:13849 Chasalow F, et al., Pgm-3. Mouse News Lett. 1980;62:74
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/20/2016
MGI 6.05
The Jackson Laboratory