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Pgm1 Gene Detail
Summary
  • Symbol
    Pgm1
  • Name
    phosphoglucomutase 1
  • Synonyms
    3230402E02Rik, Pgm-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97564
    NCBI Gene: 66681
  • Gene Overview
    MyGene.info: PGM2
Location & Maps
more
  • Sequence Map
    Chr5:64092950-64128351 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      35402 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PGM2, phosphoglucomutase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PGM2, phosphoglucomutase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MSTP006
  • Links
    NCBI Gene ID: 55276
    neXtProt AC: NX_Q96G03

  • Chr Location
    4p14; chr4:37826660-37862938 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 6693
    1 human;1 mouse;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PGM2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 6 alleles in 3 genetic backgrounds
    24 phenotype references
  • All Mutations and Alleles
    15
  • Chemically induced (ENU)
    4
  • Chemically induced (other)
    3
  • Gene trapped
    4
  • Radiation induced
    1
  • Spontaneous
    2
  • Targeted
    1
  • Genomic Mutations
    4 involving Pgm1
  • Incidental Mutations
Four electrophoretic variants are known, each with a 5-band pattern: the a allele in C57BL/6, BALB/c and AKR; b allele in DBA/2 and SJL; c allele in C3H/He; and d allele in 129/Re. Heterozygotes show a mixture of bands. Mice homozygous for a spontaneous null allele or ENU induced alleles are viable.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026404 VEGA Gene Model | MGI Sequence Detail 35402 C57BL/6J ±  kb
transcript OTTMUST00000065303 VEGA | MGI Sequence Detail 2369 Not Applicable  
polypeptide OTTMUSP00000032527 VEGA | MGI Sequence Detail 620 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    183 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000012615 phosphoglucomutase-2
  • EC
  • InterPro Domains
    IPR005844 Alpha-D-phosphohexomutase, alpha/beta/alpha domain I
    IPR005845 Alpha-D-phosphohexomutase, alpha/beta/alpha domain II
    IPR005846 Alpha-D-phosphohexomutase, alpha/beta/alpha domain III
    IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III
    IPR016066 Alpha-D-phosphohexomutase, conserved site
    IPR005843 Alpha-D-phosphohexomutase, C-terminal
Molecular
Reagents
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  • All nucleic 46
    cDNA 45
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-13275, MGD-MRK-13278, MGI:1913931
References
more
  • Summaries
    All 101
    Developmental Gene Expression 3
    Gene Ontology 10
    Phenotypes 24
  • Earliest
    J:11944 Shows TB, et al., Evolutionary evidence for a regulator gene controlling the lactate dehydrogenase B gene in rodent erythrocytes. Biochem Genet. 1969 Dec;3(6):525-36
  • Latest
    J:197599 Pitetti JL, et al., Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice. PLoS Genet. 2013;9(1):e1003160

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory