Pgk2
Gene Detail

Symbol Name ID

Pgk2 phosphoglycerate kinase 2 MGI:97563

Synonyms

Pgk-2, Tcp-2, Tcp-2

Feature Type

protein coding gene

Genetic Map

Chromosome 17

19.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)

Sequence Map

Chr17:40207018-40208609 bp, - strand From NCBI annotation of GRCm38   1592 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:57138  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: phosphoglycerate kinase
Gene Tree: Pgk2

Human homologs

Human Homolog		PGK2, phosphoglycerate kinase 2
NCBI Gene ID		5232
neXtProt AC		NX_P07205
Human Synonyms		dJ417L20.2, PGKB, PGKPS
Human Chr (Location)		6p12.3; chr6:49753364-49755053 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Mice homozygous for a knock-out allele exhibit decreased male fertility associated with reduced sperm motility.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	glycolysis, phosphorylation
Component	cytoplasm
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (122)    Tissues (105)    Images (2)
Theiler Stages: 14, 18, 21, 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	94
RT-PCR	28

cDNA source data(33)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(48) Genomic(10) cDNA(33) Primer pair(4) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000031233 (Evidence)
Entrez Gene	18663 (Evidence)
UniGene	717
DFCI	TC1580575
DoTS	DT.488729
NIA Mouse Gene Index	U260518
EC	2.7.2.3
PDB	2P9Q, 2P9T, 2PAA
Consensus CDS Project	CCDS28782.1
International Mouse Knockout Project Status	Pgk2

Sequences

Length	Strain/Species
genomic	18663	NCBI Gene Model | MGI Sequence Detail	1592	C57BL/6J
transcript	NM_031190	RefSeq | MGI Sequence Detail	1592	Not Specified
polypeptide	P09041	UniProt | EBI | MGI Sequence Detail	417	Not Applicable

All sequences(18) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(4) : SNPs(8 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001576	Phosphoglycerate kinase
InterPro	IPR015911	Phosphoglycerate kinase, conserved site
InterPro	IPR015901	Phosphoglycerate kinase, C-terminal
InterPro	IPR015824	Phosphoglycerate kinase, N-terminal
Protein Ontology	PR:000012608	phosphoglycerate kinase 2

Graphical View of Protein Domain Structure

References

(Earliest) J:16462 VandeBerg JL, et al., Mammalian testis phosphoglycerate kinase. Nat New Biol. 1973;243:48-50
(Latest) J:185195 Smith LB, et al., KATNAL1 Regulation of Sertoli Cell Microtubule Dynamics Is Essential for Spermiogenesis and Male Fertility. PLoS Genet. 2012 May;8(5):e1002697
All references(77)

Other accession IDs

MGD-MRK-13265, MGD-MRK-13274, MGD-MRK-14818