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Pgd
Gene Detail
 Symbol
Name
ID
Pgd
phosphogluconate dehydrogenase
MGI:97553
Synonyms 0610042A05Rik
Feature Type protein coding gene
Genetic Map
Chromosome 4
78.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:149149991-149166771 bp, - strand
From VEGA annotation of GRCm38

  16781 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68268  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: 6PGD
Gene Tree: Pgd

Human
homologs
Human Homolog PGD, phosphogluconate dehydrogenase
NCBI Gene ID 5226
neXtProt AC  NX_P52209
Human Synonyms  6PGD
Human Chr (Location)  1p36.22; chr1:10399028-10420144 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(14) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Pgd interacts with 85 markers (Mir7-1, Mir17, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process D-gluconate metabolic process, oxidation-reduction process, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function coenzyme binding, NADP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (212)    Tissues (106)    Images (26)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 212
cDNA source data(221)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(223) cDNA(223)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000010934 (Evidence)
Ensembl Gene ModelENSMUSG00000028961 (Evidence)
Entrez Gene110208 (Evidence)
UniGene252080
DFCITC1573185, TC1720689, TC1729682
DoTSDT.101289934, DT.101385933, DT.94374604, DT.97386225, DT.99865190
NIA Mouse Gene IndexU025797
EC1.1.1.43, 1.1.1.44
Consensus CDS ProjectCCDS38974.1
International Mouse Knockout Project StatusPgd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010934 VEGA Gene Model | MGI Sequence Detail 16781 C57BL/6J ±  kb
transcript OTTMUST00000025646 VEGA | MGI Sequence Detail 2218 Not Applicable 
polypeptide OTTMUSP00000011754 VEGA | MGI Sequence Detail 483 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(7) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(127 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006184 6-phosphogluconate-binding site
InterPro IPR006114 6-phosphogluconate dehydrogenase, C-terminal
InterPro IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
InterPro IPR006113 6-phosphogluconate dehydrogenase, decarboxylating
InterPro IPR006115 6-phosphogluconate dehydrogenase, NADP-binding
InterPro IPR013328 Dehydrogenase, multihelical
InterPro IPR012284 Fibritin/6-phosphogluconate dehydrogenase, C-terminal extension
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000012604 6-phosphogluconate dehydrogenase, decarboxylating
References (Earliest) J:13657 Chapman VM, Gene order Pgm-2 - Pgd - Gpd. Mouse News Lett. 1974;50:58
(Latest) J:187006 Sukhatme VP, et al., Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence. FEBS Lett. 2012 Jul 30;586(16):2389-95
All references(65)
Other
accession IDs
MGD-MRK-13255, MGI:1914101, MGI:2140453, MGI:2140666

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory