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Pgd Gene Detail
Summary
  • Symbol
    Pgd
  • Name
    phosphogluconate dehydrogenase
  • Synonyms
    0610042A05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:97553
    NCBI Gene: 110208
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:149149985-149166707 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 78.96 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    127 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97553
protein coding gene Chr4:149149985-149166771 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029136
protein coding gene Chr4:152968417-152985170 (-)
A/J MGP_AJ_G0029101
protein coding gene Chr4:146590381-146607099 (-)
AKR/J MGP_AKRJ_G0029049
protein coding gene Chr4:150608682-150625391 (-)
BALB/cJ MGP_BALBcJ_G0029117
protein coding gene Chr4:147100959-147117725 (-)
C3H/HeJ MGP_C3HHeJ_G0028838
protein coding gene Chr4:151169968-151186677 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029566
protein coding gene Chr4:158491899-158508679 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026812
protein coding gene Chr4:139016092-139034312 (-)
CAST/EiJ MGP_CASTEiJ_G0028251
protein coding gene Chr4:148391796-148410847 (-)
CBA/J MGP_CBAJ_G0028800
protein coding gene Chr4:163148449-163165337 (-)
DBA/2J MGP_DBA2J_G0028949
protein coding gene Chr4:146710826-146727538 (-)
FVB/NJ MGP_FVBNJ_G0028913
protein coding gene Chr4:145810159-145828777 (-)
LP/J MGP_LPJ_G0029039
protein coding gene Chr4:152905690-152922457 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028940
protein coding gene Chr4:166388339-166405055 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029598
protein coding gene Chr4:151101346-151118062 (-)
PWK/PhJ MGP_PWKPhJ_G0027971
protein coding gene Chr4:142705856-142722792 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027805
protein coding gene Chr4:145338312-145356787 (-)
WSB/EiJ MGP_WSBEiJ_G0028331
protein coding gene Chr4:151258608-151275378 (-)



Homology
more
  • Human Ortholog
    PGD, phosphogluconate dehydrogenase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PGD, phosphogluconate dehydrogenase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    6PGD
  • Links
    NCBI Gene ID: 5226
    neXtProt AC: NX_P52209
    UniProt: P52209

  • Chr Location
    1p36.22; chr1:10398992-10420511 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 68268
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: PGD
  • Protein SuperFamily
  • Gene Tree
    Pgd
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 110208 NCBI Gene Model | MGI Sequence Detail 16723 C57BL/6J ±  kb
transcript NM_001081274 RefSeq | MGI Sequence Detail 2227 C57BL/6  
polypeptide Q9DCD0 UniProt | EBI | MGI Sequence Detail 483 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000012604 6-phosphogluconate dehydrogenase, decarboxylating
  • EC
  • InterPro Domains
    IPR006184 6-phosphogluconate-binding site
    IPR006183 6-phosphogluconate dehydrogenase
    IPR006114 6-phosphogluconate dehydrogenase, C-terminal
    IPR006113 6-phosphogluconate dehydrogenase, decarboxylating
    IPR013328 6-phosphogluconate dehydrogenase, domain 2
    IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
    IPR006115 6-phosphogluconate dehydrogenase, NADP-binding
    IPR036291 NAD(P)-binding domain superfamily
Molecular
Reagents
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  • All nucleic 226
    cDNA 226

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-13255, MGI:1914101, MGI:2140453, MGI:2140666
References
more
  • Summaries
    All 62
    Developmental Gene Expression 6
    Gene Ontology 11
    Phenotypes 7
  • Earliest
    J:5600 Chapman VM, 6-Phosphogluconate dehydrogenase (PGD) genetics in the mouse: linkage with metabolically related enzyme loci. Biochem Genet. 1975 Dec;13(11-12):849-56
  • Latest
    J:240028 Bulusu V, et al., Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Dev Cell. 2017 Feb 27;40(4):331-341.e4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory