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Pgd
Gene Detail
Symbol

Name
ID
Pgd
phosphogluconate dehydrogenase
MGI:97553
Synonyms
0610042A05Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 4
78.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:149149991-149166771 bp, - strand
From VEGA annotation of GRCm38

  16781 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68268  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PGD
Protein SuperFamily: 6PGD
Gene Tree: Pgd

Human
homologs
PGD, phosphogluconate dehydrogenase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5226
neXtProt AC: NX_P52209

Human Synonyms: 6PGD

Human Chr (Location): 1p36.22; chr1:10398992-10420511 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(14) Targeted(3)
Genomic Mutations involving Pgd (1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Pgd interacts with 84 markers (Mir7-1, Mir17, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process carbohydrate metabolic process, D-gluconate metabolic process, ...
Component cytoplasm, extracellular exosome, ...
Function carbohydrate binding, carboxylic acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (212)    Tissues (106)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 212
cDNA source data(221)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pgd    NEW 
Molecular
reagents
All nucleic(223) cDNA(223)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000010934 (Evidence)
Ensembl Gene Model ENSMUSG00000028961 (Evidence)
Entrez Gene 110208 (Evidence)
UniGene 252080
DFCI TC1573185, TC1720689, TC1729682
DoTS DT.101289934, DT.101385933, DT.94374604, DT.97386225, DT.99865190
NIA Mouse Gene Index U025797
EC 1.1.1.43, 1.1.1.44
Consensus CDS Project CCDS38974.1
International Mouse Phenotyping Consortium Status Pgd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010934 VEGA Gene Model | MGI Sequence Detail 16781 C57BL/6J ±  kb
transcript OTTMUST00000025646 VEGA | MGI Sequence Detail 2218 Not Applicable 
polypeptide OTTMUSP00000011754 VEGA | MGI Sequence Detail 483 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(7) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(127 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006184 6-phosphogluconate-binding site
InterPro IPR006183 6-phosphogluconate dehydrogenase
InterPro IPR006114 6-phosphogluconate dehydrogenase, C-terminal
InterPro IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like
InterPro IPR006113 6-phosphogluconate dehydrogenase, decarboxylating
InterPro IPR013328 6-phosphogluconate dehydrogenase, domain 2
InterPro IPR012284 6-phosphogluconate dehydrogenase, domain 3
InterPro IPR006115 6-phosphogluconate dehydrogenase, NADP-binding
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000012604 6-phosphogluconate dehydrogenase, decarboxylating
References
(Earliest) J:13657 Chapman VM, Gene order Pgm-2 - Pgd - Gpd. Mouse News Lett. 1974;50:58
(Latest) J:220734 Zhang L, et al., Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1 ablation. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4003-8
All references(53)
Other
accession IDs
MGD-MRK-13255, MGI:1914101, MGI:2140453, MGI:2140666

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory